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ST3 beta-Galactoside alpha-2,3-Sialyltransferase 1 Proteins (ST3GAL1)

The protein encoded by ST3GAL1 is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. Additionally we are shipping ST3GAL1 Kits (21) and ST3GAL1 Antibodies (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ST3GAL1 6482 Q11201
ST3GAL1 20442 P54751
Rat ST3GAL1 ST3GAL1 362924  
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Top ST3GAL1 Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

ST3GAL1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
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Mouse (Murine) ,
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More Proteins for ST3 beta-Galactoside alpha-2,3-Sialyltransferase 1 (ST3GAL1) Interaction Partners

Human ST3 beta-Galactoside alpha-2,3-Sialyltransferase 1 (ST3GAL1) interaction partners

  1. rs113350588 and rs1048479 may alter the function of ST3GAL1. The GC haplotype was associated with an increased risk of death in subjects with influenza. The AT haplotype was associated with an increased risk of severe disease and death.

  2. ST3GAL1-associated transcriptomic program portends poor prognosis in glioma patients with higher tumor grades.ST3Gal1-regulated self-renewal traits are crucial to the sustenance of glioblastoma multiforme growth.

  3. Results show that ST3Gal1 uses GM130 (show GOLGA2 Proteins)-GRASP65 (show GORASP1 Proteins) and giantin, whereas C2GnT-L (show GCNT1 Proteins) uses only giantin for Golgi targeting and defective giantin dimerization in PC-3 (show PCSK1 Proteins) and DU145 prostate cancer cells causes fragmentation of the Golgi and prevents its targeting.

  4. NMIIA is the master regulator of Golgi fragmentation induced by heat shock or inhibition/depletion of HSP70 (show HSP70 Proteins)/90 through interaction with gylosyltransferases.

  5. the high expression of ST3Gal I and ST6Gal I (show ST6GAL1 Proteins), in skin tumors, is associated with tumors with greater potential for invasion and metastasis, as in the case of squamous cell carcinoma, and this may be related to their behavior.

  6. Induction of COX-2 in breast cancer cell line results in the increased expression of ST3Gal-I.

  7. Down-regulation of ST3GalI is correlated with breast cancer

  8. Over-expression of ST3Gal-I promotes mammary tumorigenesis.

  9. Although the human ST3Gal I has four N-glycan attachment sites in its catalytic domain that are potentially glycosylated, none necessary for enzyme activity, but N-glycosylation contributes to the folding and trafficking of the enzyme.

  10. ST3Gal-I inactivation or enzymatic removal of its product renders CD8+ T cells, but not CD4+ T cells, susceptible to apoptosis by differential cross-linking of O-glycoproteins in the absence of interleukin-2 and T-cell receptor (TCR) signaling.

Pig (Porcine) ST3 beta-Galactoside alpha-2,3-Sialyltransferase 1 (ST3GAL1) interaction partners

  1. these results identified the core promoter region in the pST3Gal I promoter and demonstrated that Smad-3 (show SMAD3 Proteins) binding to the Samd-3 binding site at -1020 is essential for transcriptional activation of pST3Gal I in TGF-beta1 (show TGFB1 Proteins)-induced PK-15 cells.

Mouse (Murine) ST3 beta-Galactoside alpha-2,3-Sialyltransferase 1 (ST3GAL1) interaction partners

  1. ST3GAL-1 is an independent adverse prognostic factor for recurrence and survival of patients with clear cell renal cell carcinoma (show MOK Proteins)

  2. tryptophan and cysteine residues conserved in ST3Gal I are critical for its activity

  3. ST3Gal-I mRNA is extensively expressed during Th2, but not Th1 (show HAND1 Proteins) differentiation; suggests that lack of ST3Gal-I expression in Th1 (show HAND1 Proteins) cells allows the formation of surface core2 O-glycans and supports their interactions with endothelial selectins

  4. STsGal-I deficiency shows no discernible effect on the pattern of CD8 (show CD8A Proteins) noncognate binding during thymocyte development and does not impact susceptibility of thymocytes to CD8 (show CD8A Proteins)-induced apoptosis.

  5. St3gal-1 functions to protect CD8 (show CD8A Proteins) T cells from apoptosis

ST3GAL1 Protein Profile

Protein Summary

The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. Correct glycosylation of the encoded protein may be critical to its sialyltransferase activity. This protein, which is a member of glycosyltransferase family 29, can use the same acceptor substrates as does sialyltransferase 4B. Two transcript variants encoding the same protein have been found for this gene. Other transcript variants may exist, but have not been fully characterized yet.

Gene names and symbols associated with ST3GAL1

  • ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (st3gal1)
  • ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (ST3GAL1)
  • ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (St3gal1)
  • 5330418N22Rik protein
  • AI467004 protein
  • Gal-NAc6S protein
  • Siat4 protein
  • Siat4a protein
  • SIATFL protein
  • St3gal-1 protein
  • ST3GalA protein
  • ST3GalA.1 protein
  • ST3GalI protein
  • ST3GalIA protein
  • ST3GalIA,1 protein
  • ST3O protein

Protein level used designations for ST3GAL1

alpha-2,3-sialyltransferase , CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 , SIAT4-A , ST3Gal I , ST3GalA.1 , ST3GalI , ST3O , alpha 2,3-ST 1 , beta-galactoside alpha-2,3-sialyltransferase 1 , gal-NAc6S , gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase , sialyltransferase 4A , Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase , sialyltransferase 4A (beta-galactosidase alpha-2,3-sialytransferase) , sialyltransferase 4A (beta-galactoside alpha-2,3-sialyltransferase) , sialyltransferase 4A (beta-galactoside alpha-2,3-sialytransferase) , gal beta-1,3 GalNAc alpha-2,3 sialyltransferase , CMP-N-acetylneuraminate: [beta-galactosidase alpha-2,3] sialytransferase , Gal beta1,3 GalNAc alpha2,3 sialyltransferase , ST3GAL-I sialyltransferase , sialyltransferase ST3Gal-I

GENE ID SPECIES
100329190 Xenopus (Silurana) tropicalis
396140 Gallus gallus
6482 Homo sapiens
482050 Canis lupus familiaris
445537 Sus scrofa
282351 Bos taurus
20442 Mus musculus
362924 Rattus norvegicus
101122606 Ovis aries
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