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ST3 beta-Galactoside alpha-2,3-Sialyltransferase 5 Proteins (ST3GAL5)

Ganglioside GM3 is known to participate in the induction of cell differentiation, modulation of cell proliferation, maintenance of fibroblast morphology, signal transduction, and integrin-mediated cell adhesion. Additionally we are shipping ST3 beta-Galactoside alpha-2,3-Sialyltransferase 5 Antibodies (31) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ST3GAL5 8869 Q9UNP4
ST3GAL5 20454 O88829
Rat ST3GAL5 ST3GAL5 83505 Q68G12
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Top ST3 beta-Galactoside alpha-2,3-Sialyltransferase 5 Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,073.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$388.93
Details

ST3GAL5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
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More Proteins for ST3 beta-Galactoside alpha-2,3-Sialyltransferase 5 (ST3GAL5) Interaction Partners

Human ST3 beta-Galactoside alpha-2,3-Sialyltransferase 5 (ST3GAL5) interaction partners

  1. Serum deprivation triggers upregulation of hST3Gal V gene expression through Runx2 activation by BMP signaling in MG-63 cells.

  2. this study indicated that sialylation involved in the development of MDR of AML (show RUNX1 Proteins) cells probably through ST3GAL5 or ST8SIA4 (show ST8SIA4 Proteins) regulating the activity of PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signaling and the expression of P-gp (show ABCB4 Proteins) and MRP1 (show MDM4 Proteins).

  3. Whole-exome sequencing of patients with salt and pepper syndrome shows a homozygous c.994G>A transition (p.E332K) in the ST3GAL5 gene.

  4. GM3 synthase deficiency, responsible for early-onset epilepsy syndrome, leads to a secondary respiratory chain dysfunction.

  5. Data demonstrate that valproic acid (VPA) transcriptionally regulates human GM3 synthase (hST3Gal V), which catalyzes ganglioside GM3 (show GRM6 Proteins) biosynthesis in ARPE-19 human retinal pigment epithelial cells.

  6. GM3 exhibits the potential to regulate the allosteric structural transition from inactive to a signaling EGFR dimer, by preventing the autophosphorylation of the intracellular kinase domain in response to ligand binding

  7. In vivo expression of the transcript gives rise to two human ST3Gal-V isoforms with distinct characteristics.

  8. ST6Gal I (show ST6GAL1 Proteins) and ST3Gal V were positively correlated with the high risk of pediatric acute leukemia.

  9. GM3 synthase overexpression results in reduced cell motility and in caveolin-1 (show CAV1 Proteins) upregulation in human ovarian carcinoma cells

  10. GM3 synthase mRNA levels were significantly higher in differentiated human monocyte-derived macrophages compared to monocytes and in atherosclerotic aorta compared to normal aorta

Mouse (Murine) ST3 beta-Galactoside alpha-2,3-Sialyltransferase 5 (ST3GAL5) interaction partners

  1. Functionally, the repression of St3gal5 suffices to elevate intercellular adhesion and expression of distinct junction-associated proteins, reminiscent of knockdown of Zeb1.

  2. ganglioside GM3 synthase has a role in siRNA-based spherical nucleic acid reversal of impaired wound healing in diabetic mice

  3. Results show that complete and partial deletion of the GM3 synthase gene exert distinct effects on the NP-C (Niemann-Pick disease Type C) phenotype.

  4. genes involved in the sphingolipids metabolism may be modifiers of cystogenesis, and suggest GM3 synthase as a new anti-cystic therapeutic target.

  5. Results suggest that complete, but not partial, inhibition of GM3 (show GRM6 Proteins) synthesis results in robust activation of an alternate pathway that may compensate for the complete absence of the products of GM3 synthase.

  6. the age at death of the npc1 (show NPC1 Proteins)(-/-) mouse can be significantly influenced by many factors, including differences in strain background, other inactivating gene mutations in Siat9 and lxrbeta (show NR1H2 Proteins)

  7. GM3 synthase silencing suppressed lung metastasis in murine breast cancer cells. The molecular mechanism that underlies GM3 synthase mediated migration and invasion was inhibition of the phosphoinositide-3 kinase/Akt (show AKT1 Proteins) pathway.

  8. The defect of hearing ability of GM3 synthase null mice could be attributed to the functional disorganization of the organ of Corti, and the expression of gangliosides, especially GM3 (show GRM6 Proteins), during the maturation of the cochlea.

  9. zST3GalV-2 and mST3GalV are the enzymes responsible for the synthesis of GM4 in zebrafish and mice, respectively.

ST3 beta-Galactoside alpha-2,3-Sialyltransferase 5 (ST3GAL5) Protein Profile

Protein Summary

Ganglioside GM3 is known to participate in the induction of cell differentiation, modulation of cell proliferation, maintenance of fibroblast morphology, signal transduction, and integrin-mediated cell adhesion. The protein encoded by this gene is a type II membrane protein which catalyzes the formation of GM3 using lactosylceramide as the substrate. The encoded protein is a member of glycosyltransferase family 29 and may be localized to the Golgi apparatus. Mutation in this gene has been associated with Amish infantile epilepsy syndrome. Transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with ST3GAL5

  • ST3 beta-galactoside alpha-2,3-sialyltransferase 5 (ST3GAL5)
  • ST3 beta-galactoside alpha-2,3-sialyltransferase 5 (St3gal5)
  • 3S-T protein
  • SATI protein
  • Siat9 protein
  • SIATGM3S protein
  • ST3GAL-V protein
  • ST3GalV protein
  • [a]2 protein

Protein level used designations for ST3GAL5

CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase , GM3 synthase , ST3Gal V , alpha 2,3-sialyltransferase V , ganglioside GM3 synthase , lactosylceramide alpha-2,3-sialyltransferase , sialyltransferase 9 (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase; GM3 synthase) , ST3GalV , alpha2,3-sialyltransferase , sialyltransferase 9 , GM3-specific sialytransferase , mST3Gal V , sialyltransferase 9 (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase)

GENE ID SPECIES
8869 Homo sapiens
612022 Canis lupus familiaris
404164 Bos taurus
20454 Mus musculus
83505 Rattus norvegicus
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