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Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. Additionally we are shipping STAMBP Proteins (14) and STAMBP Kits (9) and many more products for this protein.
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The authors propose a structural organization where the AMSH-SH3 binding motif interacts with the STAM2 (show STAM2 Antibodies)-SH3 domain (show ITSN1 Antibodies) and contributes to the correct positioning of AMSH prior to polyubiquitin (show UBB Antibodies) chains' cleavage.
The VHS domain of STAM2 directs AMSH to cleave longer Lys63-linked ubiquitin chains
Two siblings with classic features of MIC-CAP syndrome that harbor a novel predicted splice mutation in STAMBP
associated molecule with the SH3 domain of STAM-mediated deubiquitination of connexin 43 (show GJA1 Antibodies) protects Gap junctions from degradation
Recognition of the proximal ubiquitin is imperative for the linkage specificity and catalytic efficiency of AMSH.
Mutations in STAMBP, encoding a deubiquitinating enzyme, cause microcephaly-capillary malformation syndrome.
AMSH efficiently removes ubiquitin from the activated EGFR (show EGFR Antibodies).
tight coupling of ESCRT-III CHMP3 (show CHMP3 Antibodies) and AMSH functions and provide insight into the regulation of ESCRT-III
Studies indicate that USP8/Ubpy (show USP8 Antibodies) and AMSH interact with ESCRT components to modulate the ubiquitination status of receptors and relevant sorting proteins.
AMSH interacts with ESCRT-0 to regulate the stability and trafficking of CXCR4 (show CXCR4 Antibodies).
These data suggest that AMSH plays an important role in degrading ubiquitinated proteins and glutamate (show GRIN1 Antibodies) receptors in vivo
Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.
, associated molecule with the SH3 domain of STAM
, endosome-associated ubiquitin isopeptidase
, STAM-binding protein-like A