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Component of the N-oligosaccharyl transferase enzyme which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Additionally we are shipping STT3A Antibodies (23) and many more products for this protein.
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This study showed that Congenital Disorder of Glycosylation Caused by Mutations in STT3A.
Consensus sites containing large hydrophobic and negatively charged middle residues are frequently skipped by STT3A during protein translation.
Results show homozygous mutation in STT3A and in STT3B (show STT3B Proteins) causes congenital disorders of glycosylation.
DDIT3, STT3A, ARG2 and FAM129A immunohistochemistry does not appear to be useful in the diagnosis of thyroid follicular neoplasias, as they do not reliably distinguish follicular thyroid carcinoma from follicular thyroid adenoma.
Gene-expression data suggest a difference in expression between STT3A, Clorf24, and TFF3 (show TFF3 Proteins) in FAs (show FAS Proteins) versus carcinomas that may be detected from an FNA sample. Findings must be validated from preoperative FNAs in larger numbers
The STT3A OST (show DDOST Proteins) isoform is primarily responsible for cotranslational glycosylation of the nascent polypeptide as it enters the lumen of the endoplasmic reticulum.
Component of the N-oligosaccharyl transferase enzyme which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). SST3A seems to be involved in complex substrate specificity (By similarity).
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
, integral membrane protein 1
, intergral membrane protein 1
, oligosaccharyl transferase subunit STT3A
, STT3, subunit of the oligosaccharyltransferase complex, homolog A
, STT3A, cataylic subunit of the oligosaccharyltransferase complex
, dolichyl-diphosphooligosaccharide protein glycotransferase
, integral transmembrane protein 1
, transmembrane conserved
, transmembrane protein TMC