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Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. Additionally we are shipping SWAP Switching B-Cell Complex 70kDa Subunit Antibodies (83) and SWAP Switching B-Cell Complex 70kDa Subunit Kits (5) and many more products for this protein.
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data indicate that SWAP-70 may be involved in regulating motility of trophoblast cells during embryonic implantation and placentation.
These findings reveal an important role of SWAP-70 in the dynamic spatiotemporal regulation of F-actin networks.
Cells expressing the mutant SWAP-70 exhibited faster growth than the parental or wild-type SWAP-70-expressing cells underscoring its role in neoplastic transformation.
SWAP-70 is not required for podosome formation and F-actin turnover in dendritic cells.
SWAP-70 deficiency reveals two pathways that contribute to spontaneous maturation of DCs.
SWAP-70 controls IgE production through regulation of the antagonistic STAT6 and BCL6 occupancy of the germline IgE promoter
A novel function of the F-actin binding and regulatory protein (show TGFB1 Proteins) SWAP-70 in osteoclast biology, is reported.
regulation of eosinophil trafficking and migration by SWAP-70 is important for the development of eosinophilic inflammation after allergen exposure.
SWAP-70 regulates erythropoiesis by controlling alpha4 integrin.
in a dose-dependent manner, SWAP-70 controls IRF-4 (show IRF4 Proteins) protein expression and thereby regulates the initiation of plasma cell differentiation
SWAP-70-374 can activate some signaling pathways, including the ERK1/2 pathway, to transform MEFs
SWAP70 appears to act as a molecular intermediate between vGPCR and endothelial activation.
SWAP70 may be a target of miR (show MLXIP Proteins)-145, and it might have a potential oncogenic function.
Detection of SWAP70 antibodies during the attack period might suggest that SWAP70 is involved in Multiple Sclerosis relapse pathogenesis
The unwinding of the C-terminal alpha-helix could regulate the functions of SWAP-70 at the plasma membrane surface.
findings suggest that regulation of eosinophil trafficking and migration by SWAP-70 is important for the development of eosinophilic inflammation after allergen exposure
Overexpression of SWAP-70 altered the actin organization and lamellipodial morphology
the binding activity of SWAP-70 to non-muscle F-actin is required for membrane ruffling.
surface expression of SWAP-70 on HIV-1 infected cells as well as PBMCs; SWAP-70 may serve as a marker for T cell differentiation as well as for HIV-1 infection
SWAP-70 may be involved in regulating migration and invasion of trophoblast cells during the processes of embryonic implantation and placentation in primates.
Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity).
SWAP switching B-cell complex 70kDa subunit
, SWAP-70 protein
, switch-associated protein 70-like
, SWAP complex protein, 70 kDa
, switch-associated protein 70
, SWA-70 protein
, SWAP complex protein