SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 Proteins (SMARCB1)

The protein encoded by SMARCB1 is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. Additionally we are shipping SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 Antibodies (133) and SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SMARCB1 6598 Q12824
SMARCB1 20587 Q9Z0H3
Rat SMARCB1 SMARCB1 361825  
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Top SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 Proteins at antibodies-online.com

Showing 7 out of 20 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
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Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
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HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$333.33
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HOST_Escherichia coli (E. coli) Human His-SUMO Tag   50 μg Log in to see 11 Days
$341.00
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Yeast Human His tag   50 μg Log in to see 8 to 11 Days
$341.00
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HOST_Baculovirus infected Insect Cells Human His tag   20 μg Log in to see 2 to 3 Days
$907.50
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SMARCB1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, , ,
Mouse (Murine)

More Proteins for SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 (SMARCB1) Interaction Partners

Human SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 (SMARCB1) interaction partners

  1. Biallelic alterations in the INI1 gene were identified in 4 of the 5 cases of atypical teratoid/rhabdoid tumors. Three of the 4 cases harbored 2 different mutations, presumably on different alleles (compound heterozygous mutations), and 1 case of which had a splice-site mutation.

  2. The epithelioid variant of schwannoma is rare, and loss of SMARCB1/INI1 expression has been observed in a subset of cases. Our aim was to further define the clinicopathologic features and to evaluate SMARCB1/INI1 deficiency in a large cohort of 65 epithelioid schwannomas diagnosed between 2002 and 2015

  3. SMARCB1 is required for the integrity of SWI (show SMARCA1 Proteins)/SNF (show SNRPA Proteins) complexes.

  4. INI1 loss occurs rarely in colorectal carcinoma, where it is associated with higher grade, larger tumor size, poorer survival, mismatch repair deficiency, and BRAFV600E mutation.

  5. SWI (show SMARCA1 Proteins)/SNF (show SNRPA Proteins) complexes lacking SMARCB1 are vital determinants of drug sensitivity, not just to TOP2A (show TOP2A Proteins)-targeted agents, but to the much broader range of cancer drugs effluxed by ABCB1 (show ABCB1 Proteins).

  6. SMARCB1-deficient sinonasal carcinoma represents an emerging poorly differentiated/undifferentiated sinonasal carcinoma.

  7. Deletions in INI1 gene is associated with Small cell undifferentiated hepatoblastomas.

  8. Our results confirm the pathogenic involvement of SMARCB1/INI1 in childhood chordoma

  9. Rpt1 domain of INI1 may participate in ubiquitin recognition or binding with ubiquitin or ubiquitin related proteins.

  10. Here, the authors first confirmed that SWIRM domain of BAF155 is responsible for its interaction with BAF47 and then narrowed down the SWIRM-binding region in BAF47 to the Repeat 1 (RPT1) domain.

Mouse (Murine) SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 (SMARCB1) interaction partners

  1. The occurrence of intracranial rhabdoid tumours depends on control of Smarcb1 inactivation.

  2. These results support recent findings regarding the effectivity of EGFR (show EGFR Proteins) inhibitors in hindering the proliferation of human MRT cells and demonstrate that activation of EGFR (show EGFR Proteins) signaling in Rhabdoid tumors is SMARCB1 dependent.

  3. these findings uncover a novel role for Snf5 in oligodendrocyte generation and survival, and they offer evidence of the first genetically engineered mouse model for AT/RT in the CNS.

  4. This study show here that loss of Smarcb1 and Smarca4 (show SMARCA4 Proteins) leads to severe proliferation deficits of granule neuron precursors and a hypoplastic cerebellum.

  5. results show that Smarcb1 is required for transcriptional activation of Igfbp7 (show IGFBP7 Proteins) and show that re-introduction of Igfbp7 (show IGFBP7 Proteins) alone can hinder tumor development; results define a novel mechanism for Smarcb1-mediated tumorigenesis

  6. We find that inactivation of either Brg1 (show SMARCA4 Proteins) or Smarcb1 leads to disruptions of specific nucleosome patterning combined with a loss of overall nucleosome occupancy at a large number of promoters, regardless of their association with CpG islands.

  7. SNF5 is a key mediator of Hedgehog (show SHH Proteins) signaling and that aberrant activation of GLI1 (show GLI1 Proteins) is a previously undescribed targetable mechanism contributing to the growth of malignant rhabdoid tumor cells.

  8. Loss of the SNF5 tumor suppressor leads to elevated expression of the Polycomb (show CBX2 Proteins) gene EZH2 (show EZH2 Proteins).

  9. SNF5 knockdown inhibits p53 (show TP53 Proteins) translation by eIF4E (show EIF4E Proteins) and replacement of eIF4E (show EIF4E Proteins) in SNF5 knockdown cells restores p53 (show TP53 Proteins) expression and cell survival

  10. The loss of this protein, a core subunit of SWI (show SMARCA1 Proteins)/SNF (show SNRPA Proteins), results in highly penetrant cancer predisposition with 100% of mice developing mature CD8 (show CD8A Proteins)(+)T cell lymphoma or rare rhabdoid tumors with a median onset of only 11 weeks.

SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 (SMARCB1) Protein Profile

Protein Summary

The protein encoded by this gene is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase. This gene has been found to be a tumor suppressor, and mutations in it have been associated with malignant rhabdoid tumors. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SMARCB1

  • matrix metallopeptidase 11 (stromelysin 3) (MMP11)
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 (SMARCB1)
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 (Smarcb1)
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 (smarcb1)
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1b (smarcb1b)
  • AU020204 protein
  • Baf47 protein
  • fc51b01 protein
  • hSNFS protein
  • Ini1 protein
  • MRD15 protein
  • RDT protein
  • RTPS1 protein
  • Sfh1p protein
  • smarcb1 protein
  • Snf5 protein
  • SNF5/INI1 protein
  • SNF5L1 protein
  • Snr1 protein
  • wu:fc51b01 protein

Protein level used designations for SMARCB1

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 , SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 , matrix metalloproteinase 11 (stromelysin 3) , BAF47 , BRG1-associated factor 47 , SNF5 homolog , hSNF5 , integrase interactor 1 protein , malignant rhabdoid tumor suppressor , sucrose nonfermenting, yeast, homolog-like 1 , mSNF5 , SWI/SNF-related matrix associated protein

GENE ID SPECIES
769489 Gallus gallus
537412 Bos taurus
6598 Homo sapiens
20587 Mus musculus
443934 Xenopus laevis
486407 Canis lupus familiaris
361825 Rattus norvegicus
30731 Danio rerio
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