Salt-Inducible Kinase 2 Proteins (SIK2)

Phosphorylates 'Ser-789' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Additionally we are shipping SIK2 Antibodies (96) and SIK2 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SIK2 235344 Q8CFH6
SIK2 23235 Q9H0K1
Rat SIK2 SIK2 315649  
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Top SIK2 Proteins at antibodies-online.com

Showing 10 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$720.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$736.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 20 Days
$785.40
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details
Insect Cells Human GST tag   5 μg Log in to see 11 to 12 Days
$564.48
Details
Insect Cells Human GST tag   10 μg Log in to see 3 to 4 Days
$310.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days
$928.13
Details

SIK2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
,
Human , , , ,
, , ,

More Proteins for Salt-Inducible Kinase 2 (SIK2) Interaction Partners

Mouse (Murine) Salt-Inducible Kinase 2 (SIK2) interaction partners

  1. Data, including data from studies conducted with knockout mice, suggest that Pin1 (show PIN1 Proteins) (prolyl isomerase 1) expression in pancreatic beta-cells is markedly elevated in obesity from diet high in fat/sucrose; Pin1 (show PIN1 Proteins) appears to be involved in proliferation of beta-cells and in regulation of secretion of insulin (show INS Proteins); Pin1 (show PIN1 Proteins) interacts with Sik2 (salt-inducible kinase 2) to regulate calcium signaling.

  2. The data highlight an integral role for SIK2 and SIK3 in innate immunity by preventing the differentiation of macrophages into a potent and stable anti-inflammatory phenotype.

  3. SIK2 acts directly on CRTC2 (show CRTC2 Proteins), CRTC3 (show CRTC3 Proteins) and HDAC4 (show HDAC5 Proteins), and the cAMP-PKA pathway reduces the interaction of SIK2 with CREB (show CREB1 Proteins)-regulated transcription co-activators and PP2A (show PPP2R2B Proteins). Downstream, SIK2 increases GLUT4 (show SLC2A4 Proteins) levels and glucose uptake in adipocytes.

  4. Sik1, Sik2, and Sik3 play a key role as gluconeogenesis suppressors downstream of LKB1 (show STK11 Proteins) in the liver.

  5. Data suggest that SIK2 is critical in regulating whole-body glucose metabolism primarily by controlling the CRTC2 (show CRTC2 Proteins)-CREB (show CREB1 Proteins) function of the white adipocytes.

  6. The SIK2-p35 (show CDK5R1 Proteins)-PJA2 (show PJA2 Proteins) complex is essential for glucose homeostasis and provides a link between p35 (show CDK5R1 Proteins)-CDK5 (show CDK5 Proteins) and the AMPK (show PRKAA1 Proteins) family in excitable cells.

  7. tumor suppressor kinase LKB1 activates the downstream kinases SIK2 and SIK3 to stimulate nuclear export of class IIa histone deacetylases

  8. These findings suggest that SIK2 plays critical roles in neuronal survival, is modulated by CaMK (show CAMK2G Proteins) I/IV, and regulates CREB (show CREB1 Proteins) via TORC1 (show CRTC1 Proteins).

  9. SIK2 represses eumelanogenesis in mice.

  10. low SIK2 activity was associated with increased p300 HAT (show EP300 Proteins) activity, ChREBP (show MLXIPL Proteins) hyperacetylation, and hepatic steatosis

Human Salt-Inducible Kinase 2 (SIK2) interaction partners

  1. Data demonstrate that SIK2 and SIK3 mRNA are downregulated in adipose tissue from obese individuals and that the expression is regulated by weight change. SIK2 is also negatively associated with in vivo insulin (show INS Proteins) resistance (HOMA-IR), independently of BMI and age.

  2. Activated SIK2 plays a dual role in augmenting AMPK (show PRKAA1 Proteins)-induced phosphorylation of acetyl-CoA carboxylase and in activating the PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) pathway through p85alpha-S154 phosphorylation. These findings identify SIK2 at the apex (show APEX1 Proteins) of the adipocyte-induced signaling cascades in cancer cells.

  3. Findings suggest that SIK2 restricts autophagic flux which in the claudin-low subtype is essential for viability of triple-negative breast cancer cells.

  4. Data show that microRNA miR (show MLXIP Proteins)-203 and the salt-inducible kinase 2 (SIK2) are reverse expressed in colorectal tumors.

  5. Examination of SIK2 in prostate cancer cells found that it functions both as a positive regulator of cell-cycle (show C13orf15 Proteins) progression and a negative regulator of CREB1 (show CREB1 Proteins) activity. Also, the study shows high levels of auto-antibodies against SIK2 in plasma.

  6. this study suggests that the tightly linked regulatory loop comprised of the SIK2-PP2A (show PPP2R4 Proteins) and CaMKI (show CAMK1 Proteins) and PME-1 (show PPME1 Proteins) networks may function in fine-tuning cell proliferation and stress response.

  7. a mechanism by which the interplay between SIK2 and p97/VCP (show vcp Proteins) contributes to the regulation of ERAD in mammalian cells.

  8. These findings revealed a new function of LKB1 (show STK11 Proteins) and salt-inducible kinases as negative regulators of HTLV-1 transcription.

  9. tumor suppressor kinase LKB1 activates the downstream kinases SIK2 and SIK3 to stimulate nuclear export of class IIa histone deacetylases

  10. findings uncover SIK2 as a critical determinant in autophagy progression and further suggest a mechanism in which the interplay among kinase and deacetylase activities contributes to cellular protein pool homeostasis.

SIK2 Protein Profile

Protein Summary

Phosphorylates 'Ser-789' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.

Gene names and symbols associated with Salt-Inducible Kinase 2 Proteins (SIK2)

  • salt-inducible kinase 2 (SLK2)
  • salt inducible kinase 2 (Sik2)
  • salt-inducible kinase 2 (SIK2)
  • salt-inducible kinase 2 (Sik2)
  • G630080D20Rik protein
  • LOH11CR1I protein
  • QIK protein
  • RGD1559698 protein
  • SNF1LK2 protein

Protein level used designations for Salt-Inducible Kinase 2 Proteins (SIK2)

salt-inducible kinase 2 , SIK-2 , SNF1-like kinase 2 , salt induceable kinase 2 , salt-inducible protein kinase 2 , serine/threonine-protein kinase SIK2 , serine/threonine-protein kinase SNF1-like kinase 2 , qin-induced kinase , salt-inducible serine/threonine kinase 2

GENE ID SPECIES
100189673 Pongo abelii
235344 Mus musculus
23235 Homo sapiens
451540 Pan troglodytes
489410 Canis lupus familiaris
539570 Bos taurus
315649 Rattus norvegicus
768557 Gallus gallus
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