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Sarcoglycan, alpha (50kDa Dystrophin-Associated Glycoprotein) Proteins (SGCA)

SGCA encodes a component of the dystrophin-glycoprotein complex (DGC), which is critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix. Additionally we are shipping SGCA Antibodies (40) and SGCA Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SGCA 6442 Q16586
SGCA 20391 P82350
Rat SGCA SGCA 303468  
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Top SGCA Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$2,691.33
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

SGCA Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
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Mouse (Murine) ,
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More Proteins for Sarcoglycan, alpha (50kDa Dystrophin-Associated Glycoprotein) (SGCA) Interaction Partners

Human Sarcoglycan, alpha (50kDa Dystrophin-Associated Glycoprotein) (SGCA) interaction partners

  1. Results show that HRD1 (show SYVN1 Proteins) and RFP2 (show TRIM13 Proteins) contributes are required for the disposal of V247M alpha-sarcoglycan mutant.

  2. 2 members of a Spanish family with muscular dystrophy had a new missense mutation c409G>A, p.Glu137Lys in exon 5 of the alpha-sarcoglycan gene, as well as a paternal c739G>A, p.Val24Met mutation inexon 6.

  3. DNA analysis demonstrated homozygosity for a point mutation (574C>T) in the alpha-sarcoglycan gene.

  4. E-cadherin,alpha-dystroglycan and beta-dystroglycan levels were decreased in the oesophageal primary tumour samples, despite the presence of normal levels of dystroglycan mRNA.

  5. This study reported recessive founder LGMD2D for the Magdalen Islands, an archipelago (show FBXW7 Proteins) settled in the XIXth century, largely by Acadian immigrants.

  6. Peptide sequences in alpha-DG are substrates for protein-O-mannose N-acetylglucosaminyltransferase (show GCNT2 Proteins) 1 (POMGnT1 (show POMGNT1 Proteins)), demonstrated when a library of mannopeptides is generated which corresponds to sequences of the mucin (show SLC13A2 Proteins)-like stem region of alpha-DG.

  7. Long-term, sustainable gene expression of alpha-sarcoglycan was observed following gene transfer mediated by AAV.

  8. Absence of members of the dystrophin (show DMD Proteins)-associated glycoprotein complex constitutes a permissive environment for spontaneous development of embryonal rhabdomyosarcoma associated with mutation of p53 (show TP53 Proteins) and mutation or altered splicing of Mdm2 (show MDM2 Proteins).

  9. Two adult brothers with a mild form of LGMD2D, compound heterozygous for two missense mutations of the SGCA gene (Arg77Cys, Val247Met), presented with respiratory insufficiency while they were still ambulatory.

  10. Biglycan (show BGN Proteins) is a ligand for two members of the sarcoglycan (show SGCD Proteins) complex and regulates their expression at discrete developmental ages.

Mouse (Murine) Sarcoglycan, alpha (50kDa Dystrophin-Associated Glycoprotein) (SGCA) interaction partners

  1. The differential expression of two alpha-SG mRNAs during mouse embryonic development may be a consequence of the differential regulation of both promoters by myogenic and cardiogenic factors.

  2. Loss of sarcoglycan (show SGCD Proteins) is associated with loss of miRNA669a and myopathy.

  3. Sgca-;Sgce-null mouse shows a complete loss of residual sarcoglycans and a strong reduction in both dystrophin and dystroglycan.

  4. Impaired proliferation of Sgca-null myogenic precursors was confirmed by single fiber analysis and this difference correlated with Sgca expression during myogenic progenitor cell proliferation.

  5. Absence of members of the dystrophin (show DMD Proteins)-associated glycoprotein complex constitutes a permissive environment for spontaneous development of embryonal rhabdomyosarcoma associated with mutation of p53 (show TP53 Proteins) and mutation or altered splicing of Mdm2 (show MDM2 Proteins).

  6. These findings suggest that the sarcoglycan (show SGCD Proteins) complex serves a mechanical function in the diaphragm by contributing to muscle passive stiffness and to the modulation of the contractile properties of the muscle.

  7. Muscle masses were 40-100% larger for Sgca-null compared with age- and gender-matched wild-type mice, with the majority of the increased muscle mass for Sgca-null mice attributable to greater connective tissue and water contents

  8. Diaphragm from Sgca-null mouse presents a clear dystrophic phenotype, with necrosis, regeneration, fibre hypertrophy and splitting, excess of collagen and fatty infiltration.

  9. Deficiency of Sgca differently affects fast- and slow-twitch skeletal muscles.

  10. The alpha-SG promoter is activated by MyoD (show MYOD1 Proteins), which interacts with TFIID (show TBP Proteins) and TFIIB (show GTF2B Proteins) in a protein complex differentially located at the distal promoter and around the proximal promoter during myogenic cell differentiation.

SGCA Protein Profile

Protein Summary

This gene encodes a component of the dystrophin-glycoprotein complex (DGC), which is critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix. Its expression is thought to be restricted to striated muscle. Mutations in this gene result in type 2D autosomal recessive limb-girdle muscular dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SGCA

  • 50-kda dystrophin-associated glycoprotein (DAG2)
  • sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) (SGCA)
  • sarcoglycan, alpha (dystrophin-associated glycoprotein) (Sgca)
  • 50-DAG protein
  • 50DAG protein
  • A2 protein
  • adhalin protein
  • ADL protein
  • Asg protein
  • DAG2 protein
  • DMDA2 protein
  • LGMD2D protein
  • SCARMD1 protein
  • Sgca protein

Protein level used designations for SGCA

50 kDa dystrophin-associated glycoprotein , 50DAG , adhalin , alpha-SG , alpha-sarcoglycan , dystroglycan-2 , 50kD DAG , sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)

GENE ID SPECIES
100009178 Oryctolagus cuniculus
6442 Homo sapiens
20391 Mus musculus
303468 Rattus norvegicus
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