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Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Additionally we are shipping Sclerostin Antibodies (92) and Sclerostin Kits (50) and many more products for this protein.
Showing 10 out of 12 products:
Rat (Rattus) Sclerostin Protein expressed in Human Cells - ABIN2009022
Brunkow, Gardner, Van Ness, Paeper, Kovacevich, Proll, Skonier, Zhao, Sabo, Fu, Alisch, Gillett, Colbert, Tacconi, Galas, Hamersma, Beighton, Mulligan: Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein. in American journal of human genetics 2001
Show all 5 references for ABIN2009022
Human Sclerostin Protein expressed in Human Cells - ABIN2003109
Balemans, Ebeling, Patel, Van Hul, Olson, Dioszegi, Lacza, Wuyts, Van Den Ende, Willems, Paes-Alves, Hill, Bueno, Ramos, Tacconi, Dikkers, Stratakis, Lindpaintner, Vickery, Foernzler, Van Hul: Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST). in Human molecular genetics 2001
Show all 5 references for ABIN2003109
Sclerostin serum levels are not associated with an adverse metabolic profile during pregnancy in women with GDM and PE
Quantitative RT-PCR analysis showed that SOST expression dose-dependently decreased with increasing Wnt (show WNT2 Proteins) signaling, while BMP4 (show BMP4 Proteins) induced SOST expression
SOST and DKK1 (show DKK1 Proteins) have opposing effects on PC3 (show PCSK1 Proteins) cell invasion and bone-derived Wnt (show WNT2 Proteins) signaling positively contributes to the invasive phenotypes of PC3 (show PCSK1 Proteins)
The correlation of SOST polymorphisms with changes of BMD (show BEST1 Proteins) and bone biomarkers after treatment was analyzed.
highly sulfated (show SULF1 Proteins) glycosaminoglycans might control bone homeostasis via interference with sclerostin/LRP5 (show LRP5 Proteins)/6 complex formation.
Serum sclerostin was associated with serum intact parathyroid hormone (show PTH Proteins) in patients undergoing peritoneal dialysis.
Sclerostin and DKK-1 (show DKK1 Proteins) concentrations were markedly lower in HIV-infected youths
Serum sclerostin levels inversely associated with vascular calcification burden and progression in prevalent renal transplant recipients
significantly lower sclerostin levels in newborns born by women with vitamin D deficiency compared with newborns of nondeficient mothers.
1,25D is a direct regulator of human SOST gene and sclerostin protein expression
Our results suggested that sclerostin could be expressed in the liver and sustained successfully at high levels in the blood by using the PhiC31 integrase system, leading to trabecular bone loss.
Sclerostin depletion enhances tibial fracture healing.
SOST gene is involved in the regulation of renal interstitial fibrosis (RIF) progression. In obstructive kidney injury, SOST gene deletion would probably enhance renal fibrogenic response and promote the progression of RIF.
Data (including data from studies in knockout/transgenic mice) suggest that Lrp6 (lipoprotein receptor-related protein 6 (show LRP6 Proteins)) is required for suppression of Sost expression by parathyroid hormone (show PTH Proteins) (here, human PTH (show PTH Proteins) peptide 1-34).
These in vivo data support in vitro studies regarding the mechanism of HBM (show LRP5 Proteins)-causing mutations, and imply that HBM LRP5 (show LRP5 Proteins) receptors differ in their relative sensitivity to inhibition by SOST and DKK1 (show DKK1 Proteins).
These findings indicated that AMPK (show PRKAA1 Proteins) regulated RANKL (show TNFSF11 Proteins) and sclerostin expression through the mevalonate pathway in osteocytes.
Sclerostin inhibits bone formation through Lrp5 (show LRP5 Proteins) interaction.
thyroid hormone (show PTH Proteins)-induced changes in bone remodeling are associated with a divergent regulation of DKK1 (show DKK1 Proteins) and sclerostin
increased sclerostin production achieved by HDAC5 (show HDAC5 Proteins) shRNA is abrogated by simultaneous knockdown of MEF2C (show MEF2C Proteins), indicating that MEF2C (show MEF2C Proteins) is a major target of HDAC5 (show HDAC5 Proteins) in osteocytes
sclerostin is regulated by glutathione, N-acetylcysteine and lipoic acid in osteocytes in a process involving JNK and ERK1/2
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.