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anti-Scribbled Homolog (Drosophila) (SCRIB) Antibodies

SCRIB encodes a protein that was identified as being similar to the Drosophila scribble protein. Additionally we are shipping and SCRIB Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SCRIB 105782 Q80U72
SCRIB 23513 Q14160
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Top anti-SCRIB Antibodies at

Showing 10 out of 24 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated WB Western Blot: Scribble Antibody (7C6.D10) [NBP2-29765] - Hela cell lysate was resolved by electrophoresis, transferred to PVDF and probed with anti-Scribble, clone 7C6.D10 (0.1 ug/mL at 1 mg/mL). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP (AP124P) and a chemiluminescence detection system. Arrow indicates Scribble (~220 kDa). 0.05 mg Log in to see 10 to 13 Days
Human Rabbit Un-conjugated WB SCRIB Antibody (N-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the SCRIB antibody detected the SCRIB protein (arrow). 400 μL Log in to see 10 to 11 Days
Human Rabbit Un-conjugated IHC, IHC (p), WB Western Blot: Scribble Antibody [NBP2-15110] - Sample (30 ug of whole cell lysate) A: Hep G2 5% SDS PAGE; antibody diluted at 1:1000. Western Blot: Scribble Antibody [NBP2-15110] - Sample (30 ug of whole cell lysate) A: NIH-3T3 B: JC 5% SDS PAGE; antibody diluted at 1:1000. 0.1 mL Log in to see 6 to 9 Days
Human Rabbit Un-conjugated WB 400 μL Log in to see 6 Days
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunohistochemistry: Scribble Antibody [NBP2-47286] - Analysis of human testis shows strong cytoplasmic positivity in cells found in seminiferus ducts. Immunocytochemistry/Immunofluorescence: Scribble Antibody [NBP2-47286] - Analysis of human cell line U-2 OS shows positivity in plasma membrane & nucleus but excluded from the nucleoli. 0.1 mL Log in to see 8 to 11 Days
Human Rabbit Un-conjugated ELISA, WB   200 μL Log in to see 7 to 9 Days
Human Rabbit Alkaline Phosphatase (AP) ELISA, WB   200 μL Log in to see 7 to 9 Days
Human Rabbit APC ELISA, WB   200 μL Log in to see 7 to 9 Days
Human Rabbit Biotin ELISA, WB   200 μL Log in to see 7 to 9 Days
Human Rabbit FITC ELISA, WB   200 μL Log in to see 7 to 9 Days

SCRIB Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine)

Human ,
, , , , ,

More Antibodies against SCRIB Interaction Partners

Fruit Fly (Drosophila melanogaster) Scribbled Homolog (Drosophila) (SCRIB) interaction partners

  1. Our data reveal that the basolateral determinant Scribbled (Scrib) is required for PCV formation through optimizing BMP (show TGFb Antibodies) signaling. Scrib regulates BMP (show TGFb Antibodies)-type I receptor Thickveins (Tkv) localization at the basolateral region of PCV cells and subsequently facilitates Tkv internalization to Rab5 (show RAB5A Antibodies) endosomes, where Tkv is active

  2. Scrib module regulates epithelial polarity by influencing endocytic itineraries of Crumbs and other retromer-dependent cargo.

  3. Loss of scrib, dlg (show DLG4 Antibodies) and lgl had no effect on gonad formation, but Dlg (show DLG4 Antibodies) and Scrib in the gonadal mesoderm acted critically in the somatic wrapping of the pole cells and the internal structure of the Drosophila embryonic gonads.

  4. Drosophila scrib acts downstream of the Fat (Ft) receptor, and requires Hippo signaling for its growth regulatory functions.

  5. Loss of Scrib promotes Yorkie (show YAP1 Antibodies)/Scalloped-dependent epithelial tissue overgrowth, and this is also important for driving cooperative tumor overgrowth with oncogenic Ras-Raf (show RAF1 Antibodies) signaling.

  6. Data show that mutations causing the loss of Salvador (Sav (show SAV1 Antibodies)) or Scribble (Scrib) or activation of Ras transform normal stem cells into cancer stem cells through a multistep process in the adult Drosophila Malpighian tubules.

  7. interaction between Ras(V12) and scrib(-) clones involves JNK (show MAPK8 Antibodies) signalling propagation and JNK (show MAPK8 Antibodies)-induced upregulation of JAK (show JAK3 Antibodies)/STAT (show STAT1 Antibodies)-activating cytokines, a compensatory growth mechanism for tissue homeostasis

  8. These results demonstrate distinct aPKC and JNK (show MAPK8 Antibodies)-dependent pathways through which loss of Scrib promotes tumourigenesis in Drosophila.

  9. Study provide evidence that scrib and dlg (show DLG4 Antibodies) function differentially in anterior and posterior patterning of the follicular epithelium at oogenesis. Further genetic analysis indicates that scrib and dlg (show DLG4 Antibodies) act in a common pathway to regulate PFC (show CFP Antibodies) fate induction.

  10. conclude that Dlg (show DLG4 Antibodies)/Scrib/Lgl are important in regulating cortical polarity, cell size asymmetry and mitotic spindle asymmetry in Drosophila neuroblasts

Mouse (Murine) Scribbled Homolog (Drosophila) (SCRIB) interaction partners

  1. we provide genetic evidence of a unique link between skin carcinogenesis and loss of the epithelial polarity regulator Scrib, emphasizing that Scrib exerts a wide-spread tumor suppressive function in epithelia.

  2. The polarity protein Scribble regulates myelination and remyelination in the central nervous system.

  3. Scrib is a regulator of tissue stem cells, controlling population expansion and self-renewal with Scrib expression dynamics directing satellite cell fate.

  4. Scrib is a novel proinflammatory regulator in endothelial cells, which maintains the protein expression of GATA-like protein-1 (show ZGLP1 Antibodies).

  5. The Scrib-Rac1 interaction plays a crucial role in the organization of developing cardiomyocytes and formation of the ventricular myocardium.

  6. We show that loss of Scrib and activated oncogenic KRas cooperate in vivo, resulting in more aggressive lung tumors

  7. findings, based on a definitive genetic mouse model provide fundamental insights into mammary duct maturation and homeostasis and reveal that Scrib loss activates a MAPK (show MAPK1 Antibodies)/Fra1 (show FOSL1 Antibodies) pathway that alters mammary progenitor activity

  8. The Scribble knockout fetus exhibits exomphalos (intact and ruptured), in contrast to the original published phenotype of gastroschisis.

  9. Scrib is required to maintain epithelial identity and that loss of Scrib can culminate in EMT (show ITK Antibodies), mediated, at least in part, through TGFbeta (show TGFB1 Antibodies) signaling.

  10. B cell differentiation does not require polarity proteins of the Scribble complex, and the findings do not support a role for asymmetric cell division in B cell activation (show BLNK Antibodies) and differentiation.

Zebrafish Scribbled Homolog (Drosophila) (SCRIB) interaction partners

  1. Zygotic expression of Scribble1 (scrb1) is required for migration of the nVII motor neurons mainly in a non cell-autonomous manner, while maternal expression is required for convergent extension movements during gastrulation.

  2. Suppression of scrib and puf60 in zebrafish (show PUF60 Antibodies)leads to reduction in body length, small head size, and craniofacial defects.

  3. It was found that Scribble is required for oriented cell division and that its function in this process is independent of canonical apicobasal and planar polarity pathways.

  4. Lpp interacts with the PCP (show PRCP Antibodies) protein Scrib in zebrafish, and that Lpp and Scrib cooperate for the mediation of convergence and extension.

  5. Scribble is a candidate link between Fat and the Hippo signaling cascade in vertebrates

Human Scribbled Homolog (Drosophila) (SCRIB) interaction partners

  1. Data show hepatitis C virus (HCV) nonstructural protein 4B (NS4B) PDZ (show INADL Antibodies)-binding motif (PBM) promotes the colony formation of hepatoma cells by degrading human Scribble protein.

  2. the inclusion/exclusion of specific SCRIB exons is a mechanistic hallmark of breast cancer, which could potentially be exploited to develop more efficient diagnostics and therapies.

  3. loss of Scribble-induced HuR (show ELAVL1 Antibodies) translocation mediates the accumulation of Snail (show SNAI1 Antibodies) via activation of the p38 MAPK (show MAPK14 Antibodies) pathway.

  4. The two PDZ (show INADL Antibodies) domains within the PDZ34 tandem of Scribble, a cell polarity regulator, tightly pack in a 'front-to-back' mode to form a compact supramodule.

  5. We show that loss of Scrib and activated oncogenic KRas cooperate in vivo, resulting in more aggressive lung tumors

  6. High levels of mislocalized SCRIB functions as a neomorph to promote mammary tumorigenesis.

  7. miR (show MLXIP Antibodies)-296-5p/SCRIB axis plays a role in breast carcinogenesis

  8. This study demonstrated that rare deleterious mutations of SCRIB may contribute to the multifactorial risk for human spina bifida.

  9. These data suggests a novel role for Scribble in positively regulating tight junction assembly through transcriptional regulation of an epithelial-to-mesenchymal signaling program.

  10. SHOC2 (show SHOC2 Antibodies) and MRAS (show MRAS Antibodies) form a complex with SCRIB.

SCRIB Antigen Profile

Protein Summary

This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.

Gene names and symbols associated with SCRIB

  • scribbled (scrib) antibody
  • scribbled homolog (Drosophila) (Scrib) antibody
  • scribbled homolog (Drosophila) (scrib) antibody
  • scribbled planar cell polarity protein (SCRIB) antibody
  • 0424/05 antibody
  • AI118201 antibody
  • CG5462 antibody
  • CG5467 antibody
  • CG31082 antibody
  • CG42614 antibody
  • CG43398 antibody
  • Crc antibody
  • CRIB antibody
  • CRIB1 antibody
  • CT17324 antibody
  • Dmel\\CG43398 antibody
  • Dmel_CG5462 antibody
  • Dmel_CG5467 antibody
  • Dmel_CG31082 antibody
  • Dmel_CG42614 antibody
  • ird antibody
  • ird15 antibody
  • l(3)673 antibody
  • l(3)c00119 antibody
  • l(3)j7B3 antibody
  • l(3)S042405 antibody
  • MENE (3R)-F antibody
  • mKIAA0147 antibody
  • Scb antibody
  • SCR antibody
  • scrb antibody
  • SCRB1 antibody
  • Scrib antibody
  • SCRIB1 antibody
  • scribble antibody
  • scribble1 antibody
  • si:ch211-12p8.1 antibody
  • si:zc12p8.1 antibody
  • smi97B antibody
  • vart antibody
  • Vartul antibody

Protein level used designations for SCRIB

CG43398-PA , CG43398-PB , CG43398-PC , CG43398-PD , CG43398-PH , CG43398-PI , CG43398-PJ , CG43398-PK , CG43398-PL , CG43398-PM , CG43398-PN , CG43398-PO , CG43398-PP , CG43398-PQ , CG43398-PR , CG43398-PS , CG43398-PT , CG43398-PU , CG43398-PX , gp150-like , immune response deficient 15 , lethal (3) c00119 , scrib-PA , scrib-PB , scrib-PC , scrib-PD , scrib-PH , scrib-PI , scrib-PJ , scrib-PK , scrib-PL , scrib-PM , scrib-PN , scrib-PO , scrib-PP , scrib-PQ , scrib-PR , scrib-PS , scrib-PT , scrib-PU , scrib-PX , scribble , scribbles , smell impaired 97B , vartul , PDZ-domain protein scribble , circletail , protein scribble homolog , scribble homolog 1 , landlocked , llk , scribbled homolog

44448 Drosophila melanogaster
105782 Mus musculus
368473 Danio rerio
23513 Homo sapiens
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