Sec61 alpha 1 Subunit (S. Cerevisiae) Proteins (SEC61A1)

The protein encoded by SEC61A1 has similarity to a mouse protein which suggests a role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. Additionally we are shipping Sec61 alpha 1 Subunit (S. Cerevisiae) Antibodies (39) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SEC61A1 29927 P61619
SEC61A1 53421 P61620
Rat SEC61A1 SEC61A1 80843 P61621
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Top Sec61 alpha 1 Subunit (S. Cerevisiae) Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$333.33
Details

SEC61A1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Sec61 alpha 1 Subunit (S. Cerevisiae) (SEC61A1) Interaction Partners

Human Sec61 alpha 1 Subunit (S. Cerevisiae) (SEC61A1) interaction partners

  1. The discovery of export-specific sec61 mutants and of mammalian ER-associated degradation (ERAD) substrates whose export is dependent on the 19S regulatory particle suggest that dismissal of a role of Sec61 in export may have been premature.

  2. the effect of mycolactone on transmembrane protein biogenesis depends on how the nascent chain initially engages the Sec61 complex.

  3. data provide definitive genetic evidence that Sec61 is the host receptor mediating the diverse immunomodulatory effects of mycolactone and identify Sec61 as a novel regulator of immune cell functions.

  4. findings provide a mechanism by which mutations in SEC61A1 lead to an autosomal-dominant syndromic form of progressive chronic kidney disease; we highlight protein translocation defects across the endoplasmic reticulum membrane, the principal role of the SEC61 complex, as a contributory pathogenic mechanism for autosomal-dominant tubulo-interstitial kidney disease

  5. Nuclear envelope associated endosome-mediated transfer depends on the nuclear envelope proteins SUN1 (show SUN1 Proteins) and SUN2 (show SUN2 Proteins), as well as the Sec61 translocon complex.

  6. Cotransin, a substrate-selective Sec61 inhibitor, traps nascent transmembrane domains in the cytosolic vestibule, permitting detailed interrogation of an early pre-integration intermediate.

  7. BiP (show GDF10 Proteins) facilitates Sec61 channel closure (i.e. limits ER Ca(2 (show CA2 Proteins)+) leakage) via the Sec61 channel with the help of ERj3 (show DNAJB11 Proteins) and ERj6

  8. Sec61 complex is calcium permeable, the Sec61 complex is tightly regulated in its equilibrium between the closed and open conformations, or "gated", by ligands, such as signal peptides of the transport substrates

  9. Short secretory proteins appear to be ubiquitously transported across the ER membrane through the Sec61 translocon.

  10. The human SEC61A1 gene is essential for cell growth and viability.

Mouse (Murine) Sec61 alpha 1 Subunit (S. Cerevisiae) (SEC61A1) interaction partners

  1. Interaction of ribosomes and Sec62 (show TLOC1 Proteins) with the core Sec61 translocon is mutually exclusive.

  2. SEC61A1 gene silencing inhibits co- and post-translational transport of presecretory proteins into endoplasmic reticulum.

  3. Diabetes can bemapped to a point mutation in the Sec61a1 gene that encodes a His to Tyr (show TYR Proteins) substitution at amino acid 344.

Zebrafish Sec61 alpha 1 Subunit (S. Cerevisiae) (SEC61A1) interaction partners

  1. A screen for mutations that affect habenular laterality led to the identification of the sec61a-like 1(sec61al1) gene.

Sec61 alpha 1 Subunit (S. Cerevisiae) (SEC61A1) Protein Profile

Protein Summary

The protein encoded by this gene has similarity to a mouse protein which suggests a role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. It may also be required for the assembly of membrane and secretory proteins. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with SEC61A1

  • Sec61 alpha 1 subunit (sec61a1)
  • Sec61 alpha 1 subunit (S. cerevisiae) (SEC61A1)
  • preprotein translocase Sec61 subunit alpha (sec61a1)
  • Sec61 alpha 1 subunit (Sec61a1)
  • Sec61 alpha 1 subunit (S. cerevisiae) (Sec61a1)
  • Sec61 alpha 1 subunit (S. cerevisiae) (sec61a1)
  • Sec61 alpha 2 subunit (S. cerevisiae) (SEC61A2)
  • Sec61, alpha subunit 2 (S. cerevisiae) (Sec61a2)
  • similar to S. cerevisiae SEC61 (YLR378C) membrane component of ER protein translocation apparatus (SEC61)
  • AA408394 protein
  • AA410007 protein
  • chunp6898 protein
  • fb62c11 protein
  • HSEC61 protein
  • SEC61 protein
  • Sec61a protein
  • SEC61A1 protein
  • sec61al1 protein
  • sec61alpha protein
  • secY1 protein
  • wu:fb62c11 protein

Protein level used designations for SEC61A1

protein transport protein SEC61 alpha subunit , Sec61 alpha 1 subunit (S. cerevisiae) , transport protein Sec61 alpha subunit , protein transport protein Sec61 subunit alpha isoform 1 , sec61 alpha-1 , Protein transport protein Sec61 subunit alpha , protein transport protein Sec61 subunit alpha-like , Sec61 alpha-1 , protein transport protein Sec61 subunit alpha , sec61 homolog , sec61 homologue , SEC61, alpha subunit , transport protein sec61 alpha subunit , Sec61 alpha subunit homolog , Sec61 alpha form 1 , Sec61 alpha like 1 , protein transport protein Sec61 subunit alpha-like 1 , protein transport protein Sec61 subunit alpha isoform 2 , sec61 alpha-2 , Sec61 alpha form 2 , Sec61 alpha , hypothetical protein

GENE ID SPECIES
379936 Xenopus laevis
416023 Gallus gallus
448033 Xenopus (Silurana) tropicalis
460669 Pan troglodytes
8925650 Haloferax volcanii DS2
100144911 Acyrthosiphon pisum
100173741 Pongo abelii
100413259 Callithrix jacchus
100603743 Nomascus leucogenys
29927 Homo sapiens
404006 Canis lupus familiaris
100155306 Sus scrofa
53421 Mus musculus
80843 Rattus norvegicus
505064 Bos taurus
192298 Danio rerio
614128 Bos taurus
55176 Homo sapiens
57743 Mus musculus
3647462 Candida albicans SC5314
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