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anti-Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC) Antibodies

SPARC encodes a cysteine-rich acidic matrix-associated protein. Additionally we are shipping SPARC Kits (48) and SPARC Proteins (43) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SPARC 20692 P07214
SPARC 6678 P09486
SPARC 24791 P16975
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Top anti-SPARC Antibodies at antibodies-online.com

Showing 10 out of 224 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of SPARC Antibody (C-term) in Y79 cell line lysates (35ug/lane). SPARC (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated WB SPARC Antibody (C-term)(Ascites) (ABIN1882278) western blot analysis in Hela cell line lysates (35 µg/lane). This demonstrates the SPARC antibody detected the SPARC protein (arrow). 0.1 mL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (fro), WB 70 μg Log in to see 6 to 8 Days
$544.50
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-SPARC Polyclonal Antibody, Unconjugated (ABIN738141) at 1:200 followed by conjugation to the secondary antibody and DAB staining. Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-SPARC Polyclonal Antibody, Unconjugated at 1:200 followed by conjugation to the secondary antibody and DAB staining. 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Mouse Un-conjugated FACS, IHC Detection of SPARC in HT1080 Human Cell Line by Flow Cytometry. HT1080 human fibrosarcoma cell line was stained with Mouse Anti-Human SPARC Monoclonal Antibody. SPARC/Osteonectin in Human Ovary Cancer. SPARC/Osteonectin was detected in immersion fixed paraffin-embedded sections of human ovarian clear cell carcinoma tissue using Human SPARC/Osteonectin Monoclonal Antibody. Lower panel shows a lack of labeling when primary antibodies are omitted and tissue is stained only with secondary antibody followed by incubation with detection reagents. 100 μg Log in to see 6 to 7 Days
$387.19
Details
Mouse Rat Un-conjugated FACS, IHC, WB SPARC/Osteonectin in Mouse Ovary. SPARC/Osteonectin was detected in perfusion fixed frozen sections of mouse ovary using Mouse SPARC/Osteonectin Monoclonal Antibody. Detection of Mouse SPARC by Western Blot. Western blot shows lysates of C2C12 mouse myoblast cell line and mouse placenta tissue. PVDF membrane was probed with 2 ug/mL of Rat Anti-Mouse SPARC Monoclonal Antibody. This experiment was conducted under reducing conditions. 500 μg Log in to see 6 to 7 Days
$442.31
Details
Human Goat Un-conjugated FACS, IHC, SimWes, WB 100 μg Log in to see 6 to 7 Days
$485.63
Details
Mouse Goat Un-conjugated FACS, IHC, WB SPARC/Osteonectin in Mouse Embryo. SPARC/Osteonectin was detected in immersion fixed frozen sections of mouse embryo (E15) using Mouse SPARC/ Osteonectin Antigen Affinity-purified Polyclonal Antibody. Specific staining was localized to developing cartilage. Detection of Mouse SPARC by Western Blot. Western blot shows lysates of C2C12 mouse myoblast cell line and mouse placenta tissue. PVDF membrane was probed with 0.2 ug/mL of Goat Anti-Mouse SPARC Antigen Affinity-purified Polyclonal Antibody. This experiment was conducted under reducing conditions. 100 μg Log in to see 6 to 7 Days
$485.63
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 2 to 3 Days
$306.90
Details

SPARC Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-SPARC Antibodies

  1. Mouse (Murine) Polyclonal SPARC Primary Antibody for FACS, IHC - ABIN4899335 : Arnold, Rivera, Carbon, Toombs, Chang, Bradshaw, Brekken: Losartan slows pancreatic tumor progression and extends survival of SPARC-null mice by abrogating aberrant TGF? activation. in PLoS ONE 2012 (PubMed)
    Show all 9 references for ABIN4899335

  2. Human Polyclonal SPARC Primary Antibody for EIA, IHC (fro) - ABIN265179 : Schäkel, Mayer, Federle, Schmitz, Riethmüller, Rieber: A novel dendritic cell population in human blood: one-step immunomagnetic isolation by a specific mAb (M-DC8) and in vitro priming of cytotoxic T lymphocytes. in European journal of immunology 1999 (PubMed)
    Show all 7 references for ABIN265179

  3. Human Polyclonal SPARC Primary Antibody for FACS, IHC - ABIN4899340 : Aguilera, Rivera, Hur, Carbon, Toombs, Goldstein, Dellinger, Castrillon, Brekken: Collagen signaling enhances tumor progression after anti-VEGF therapy in a murine model of pancreatic ductal adenocarcinoma. in Cancer research 2014 (PubMed)
    Show all 7 references for ABIN4899340

  4. Mouse (Murine) Monoclonal SPARC Primary Antibody for FACS, IHC - ABIN4899334 : Weaver, Sage, Yan: Absence of SPARC in lens epithelial cells results in altered adhesion and extracellular matrix production in vitro. in Journal of cellular biochemistry 2006 (PubMed)
    Show all 5 references for ABIN4899334

  5. Human Polyclonal SPARC Primary Antibody for IF (p), IHC (p) - ABIN738141 : Chen, Wang, Xi, Xue, He, Zhang, Zhao: SPARC is a key regulator of proliferation, apoptosis and invasion in human ovarian cancer. in PLoS ONE 2012 (PubMed)
    Show all 3 references for ABIN738141

  6. Human Monoclonal SPARC Primary Antibody for WB - ABIN1882278 : Bradshaw, Graves, Motamed, Sage: SPARC-null mice exhibit increased adiposity without significant differences in overall body weight. in Proceedings of the National Academy of Sciences of the United States of America 2003 (PubMed)
    Show all 3 references for ABIN1882278

  7. Human Polyclonal SPARC Primary Antibody for WB - ABIN871733 : Wewer, Albrechtsen, Fisher, Young, Termine: Osteonectin/SPARC/BM-40 in human decidua and carcinoma, tissues characterized by de novo formation of basement membrane. in The American journal of pathology 1988 (PubMed)
    Show all 3 references for ABIN871733

  8. Human Monoclonal SPARC Primary Antibody for FACS, IHC - ABIN4899338 : Moreno, Ball, Andrade, McDermid, Stanimirovic: Insulin-like growth factor binding protein-4 (IGFBP-4) is a novel anti-angiogenic and anti-tumorigenic mediator secreted by dibutyryl cyclic AMP (dB-cAMP)-differentiated glioblastoma cells. in Glia 2006 (PubMed)
    Show all 2 references for ABIN4899338

  9. Human Polyclonal SPARC Primary Antibody for EIA, WB - ABIN453390 : Said, Frierson, Chernauskas, Conaway, Motamed, Theodorescu: The role of SPARC in the TRAMP model of prostate carcinogenesis and progression. in Oncogene 2009 (PubMed)
    Show all 2 references for ABIN453390

More Antibodies against SPARC Interaction Partners

Zebrafish Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC) interaction partners

  1. these data identify a contributory role for DNA methylation (show HELLS Antibodies) in regulating sparc expression in zebrafish embryogenesis.

  2. Results establish a role for an ECM (show MMRN1 Antibodies) protein (Sparc) as an important regulator of embryonic haematopoiesis during early development in zebrafish.

  3. Data show that Sparc (Osteonectin) functions in morphogenesis of the pharyngeal skeleton and inner ear in zebrafish.

  4. Sparc is directly required for normal otolith growth

Mouse (Murine) Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC) interaction partners

  1. SPARC isoforms, acting on Adipose stromal cells through distinct mechanisms, have an additive effect in inducing ASC (show STS Antibodies) migration.

  2. SPARC levels were not associated with efficacy in patients with MPC. This exploratory analysis does not support making treatment decisions regarding nab-paclitaxel plus gemcitabine or gemcitabine alone in MPC based on SPARC expression.

  3. SPARC is proposed to act as a critical regulator of transglutaminase activity on collagen I with implications for mechanical strength of tissues.

  4. Tumor-produced SPARC and VCAM1 (show VCAM1 Antibodies) are regulators of cancer extravasation.

  5. The results of this study indicated that the loss of p53 (show TP53 Antibodies) by deletion/mutation in the early stages of glioma formation may cooperate with the induction of SPARC to potentiate cancer cell survival and escape from immune surveillance.

  6. This work suggests that SPARC could affect anxiety-related behavior by modulating neuronal activity, and that depression-related behavior is dependent upon the adult expression of SPARC, which affects adult brain function.

  7. SPARC has a significant role in the development of concanavalin A -induced severe liver injury.

  8. SPARC acts as an important mediator of age-related cardiac inflammation by increasing the expression of macrophage M1 markers and decreasing M2 markers.

  9. SPARC inhibits growth factor-induced signaling in both INS-1 beta cells and primary mouse islets, and inhibits IGF-1-induced proliferation of INS-1 beta cells.

  10. Age and SPARC change the extracellular matrix composition of the left ventricle.

Human Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC) interaction partners

  1. that SPARC-mediated degradation of the extracellular matrix, and its possible association with MMPs, might contribute to progression of phyllodes tumors

  2. WIN-dependent increase in the level of SPARC plays a critical role in sensitizing osteosarcoma cells to TRAIL action

  3. high SPARC-expression was a significant predictor of poor OS in HPV-negative OPSCC patients using Kaplan-Meier analysis and the log-rank test

  4. We identified five new biomarkers: GDF15 (show GDF15 Antibodies), osteonectin, TRAP5, TWEAK (show TNFSF12 Antibodies), and YKL40 (show CHI3L1 Antibodies) as being promising markers for monitoring bone metastases.

  5. SPARC levels were not associated with efficacy in patients with MPC. This exploratory analysis does not support making treatment decisions regarding nab-paclitaxel plus gemcitabine or gemcitabine alone in MPC based on SPARC expression.

  6. CD90 (show THY1 Antibodies) is upregulated in gastric cancer and inhibits gastric cancer cell apoptosis by modulating the expression level of SPARC protein.

  7. SPARC might be an unfavorable indicator in patients with pancreatic cancer, especially in the stroma.[Review]

  8. tracheal aspirate SPARC levels predicted development of bronchopulmonary dysplasia or death.

  9. SPARC is associated with carcinogenesis of oral squamous epithelium.

  10. Studies indicate that SPARC (secreted protein acidic and rich in cysteine) gene is involved in the development and progression of pancreatic ductal adenocarcinoma (PDAC).

Cow (Bovine) Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC) interaction partners

  1. findings indicate that secreted protein acidic cysteine-rich (SPARC) is intricately regulated by pro-angiogenic and other growth factors together with components of the extracellular matrix during the follicle-luteal transition

  2. This study reports the temporal changes in vascular endothelial growth factor A (VEGFA (show VEGFA Antibodies)), fibroblast growth factor 2 (FGF2 (show FGF2 Antibodies)) and osteonectin during the follicular-luteal transition and corpus luteum development in the cow.

Horse (Equine) Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC) interaction partners

  1. data suggest that SPARC might modulate angiogenesis during wound healing in the horse, which could protect against the disproportionate fibroplasia commonly afflicting limb wounds and leading to the development of exuberant granulation tissue

SPARC Antigen Profile

Protein Summary

This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion.

Gene names and symbols associated with SPARC

  • secreted acidic cysteine rich glycoprotein (sparc) antibody
  • secreted acidic cysteine rich glycoprotein (Sparc) antibody
  • secreted protein, acidic, cysteine-rich (osteonectin) (SPARC) antibody
  • secreted protein, acidic, cysteine-rich (osteonectin) (Sparc) antibody
  • SPARC protein (MGC64258) antibody
  • SPARC-like (LOC100855736) antibody
  • AA517111 antibody
  • BM-40 antibody
  • hm:zeh0062 antibody
  • ON antibody
  • SPARC antibody

Protein level used designations for SPARC

SPARC , osn , osteonectin , ON , basement-membrane protein 40 , secreted protein acidic and rich in cysteine , BM-40 , cysteine-rich protein , Secreted acidic cystein-rich glycoprotein (osteonectin) , secreted acidic cysteine rich glycoprotein

GENE ID SPECIES
321357 Danio rerio
20692 Mus musculus
6678 Homo sapiens
282077 Bos taurus
24791 Rattus norvegicus
595124 Sus scrofa
100009355 Oryctolagus cuniculus
386571 Gallus gallus
100860800 Capra hircus
595143 Canis lupus familiaris
100060119 Equus caballus
100174069 Pongo abelii
379441 Xenopus laevis
100855736 Canis lupus familiaris
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