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Secreted phosphoprotein 1 Proteins (SPP1)

Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. Additionally we are shipping Osteopontin Antibodies (428) and Osteopontin Kits (118) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SPP1 6696 P10451
SPP1 20750 P10923
SPP1 25353 P08721
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Top Osteopontin Proteins at

Showing 10 out of 57 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag Secreted phosphoprotein 1 (SPP1) (AA 17-300), (partial) protein (His tag) 50 μg Log in to see 9 to 11 Days
HOST_HEK-293 Cells Human His tag Human Osteopontin, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 80%. 100 μg Log in to see 2 to 3 Days
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
HOST_HEK-293 Human Un-conjugated   10 μg Log in to see 10 to 12 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human MBP tag 10% SDS-PAGE stained with Coomassie Blue (CB) and peptide fingerprinting by MALDI-TOF mass spectrometry 100 μg Log in to see 5 to 7 Days
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
HOST_Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 11 to 13 Days
HOST_Mammalian Cells Human His tag   50 μg Log in to see 5 Days

SPP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , , , , , ,
, , ,
Mouse (Murine)

Rat (Rattus)

Top referenced Osteopontin Proteins

  1. Human Osteopontin Protein expressed in HEK-293 - ABIN2666563 : Yokosaki, Tanaka, Higashikawa, Yamashita, Eboshida: Distinct structural requirements for binding of the integrins alphavbeta6, alphavbeta3, alphavbeta5, alpha5beta1 and alpha9beta1 to osteopontin. in Matrix biology : journal of the International Society for Matrix Biology 2005 (PubMed)
    Show all 5 references for ABIN2666563

  2. Human Osteopontin Protein expressed in Escherichia coli (E. coli) - ABIN1047487 : Kiefer, Bauer, Barr: The cDNA and derived amino acid sequence for human osteopontin. in Nucleic acids research 1989 (PubMed)
    Show all 3 references for ABIN1047487

  3. Human Osteopontin Protein expressed in Escherichia coli (E. coli) - ABIN668040 : Koh, da Silva, Bansal, Bansal, Sun, Lee, Glogauer, Sodek, Zohar: Role of osteopontin in neutrophil function. in Immunology 2007 (PubMed)
    Show all 2 references for ABIN668040

  4. Human Osteopontin Protein expressed in HEK-293 Cells - ABIN2181569 : Christensen, Nielsen, Haselmann, Petersen, Sørensen: Post-translationally modified residues of native human osteopontin are located in clusters: identification of 36 phosphorylation and five O-glycosylation sites and their biological implications. in The Biochemical journal 2005 (PubMed)

  5. Human Osteopontin Protein expressed in Human Cells - ABIN2002652 : Nagasaka, Matsue, Matsushima, Aoki, Nakamura, Kambe, Kon, Uede, Shimada: Osteopontin is produced by mast cells and affects IgE-mediated degranulation and migration of mast cells. in European journal of immunology 2008 (PubMed)

More Proteins for Secreted phosphoprotein 1 (SPP1) Interaction Partners

Human Secreted phosphoprotein 1 (SPP1) interaction partners

  1. The TALK-1/iOPN complex caused Vm hyperpolarization and reduced beta-cell glucose-stimulated Ca2 (show CA2 Proteins)+ influx, which is predicted to inhibit glucose stimulated insulin (show INS Proteins) secretion.

  2. Data show that increased osteopontin levels are independently associated with type 1 diabetes mellitus (T1DM) pediatric patients.

  3. High circulating levels of SSP1 (show SENP6 Proteins) is associated with melanoma.

  4. High SPP1 expression is associated with malignant pleural mesothelioma.

  5. Studies indicate it was unable to detect any osteopontin (OPN) protein in the 3 pancreatic ductal adenocarcinoma (PDA) cell lines studied and neither the quantity nor the intensity of OPN staining correlated with any of the pathologic variables available to us in the PDA tissue microarray analysis.

  6. In conclusion, plasma level of OPN may act as diagnostic adjuvant biomarkers for community-acquired pneumonia (CAP) and further play a role in clinical assessment of the severity of CAP, which could potentially guide the development of treatment strategies.

  7. In patients with proliferative plasma cell disorders, a correlation was determined between VEGF (show VEGFA Proteins) and interstitial OPN with angiogenic parameters in the monoclonal gammopathy of undetermined significance stage of the disease. In advanced stages, there was a negative correlation between OPN and interstitial OPN with parameters of angiogenesis. Overall survival was significantly shorter for patients with negative OPN.

  8. SPP1 expression is upregulated in human masticatory mucosa during wound healing

  9. High OPN expression is associated with gastric cancer.

  10. Treatment with brefelamide induced Smad4 (show SMAD4 Proteins) expression, and knockdown of Smad4 (show SMAD4 Proteins) by RNA interference partially diminished the inhibitory effect of brefelamide on OPN. These results indicate that brefelamide inhibited OPNmediated cell invasion through restoration of the OPN repression by TGFbeta (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) signaling

Pig (Porcine) Secreted phosphoprotein 1 (SPP1) interaction partners

  1. These data suggested that methylation in the OPN promoter plays a crucial role in the regulation of OPN expression that we found in cloned pigs genome.

  2. The striking breed differences between hyperprolific Large White and Meishanin pigs of secreted phospoprotein 1 expression in endometrium suggest that SPP1 may be associated with placental efficiency.

  3. Microglia incubated in vitro with different concentrations (0.1 fM-1 nM) of recombinant osteopontin showed increased proliferation at 10 fM.

  4. results of this study reveal faster growth rate and differences in pig productivity according to genotypes of the SPP1 gene

  5. Osteopontin could play an important role in the development of neointimal hyperplasia in venous conduits after coronary artery bypass grafting.

  6. A different MSSCP pattern was shown in osteopontin which indicates that mutation is located in promotor region; the A --> G transitions was identified in two positions -617 and -608

  7. The 3' terminal end of the first intron of porcine SPP1 harbors a C/EBPbeta (show CEBPB Proteins) binding site and this binding site is negatively affected by the mutant G allele.

  8. in pregnant pigs SPP1 is induced by conceptus estrogen in uterine luminal epithelium and is regulated in a manner coincident with placental progesterone production

  9. osteopontin promotes pathologic mineralization via calcium pyrophosphate dihydrate crystal formation in articular cartilage.

  10. Osteopontin is detected in the majority of germ cells and is involved in spermatogenesis in boar testis.

Mouse (Murine) Secreted phosphoprotein 1 (SPP1) interaction partners

  1. OPN induces oxidative stress via the involvement of mitochondria and NOX-4 (show NOX4 Proteins). It may affect mitochondrial morphology and integrity, at least in part, via the involvement of BIK (show BIK Proteins).

  2. Endogenous osteopontin plays a critical role in the prevention of phosphate-induced nephrocalcinosis and vascular calcification in response to high phosphate load.

  3. GATA4 (show GATA4 Proteins) acts as a negative regulator of Bsp (show KLK6 Proteins) expression in osteoblasts.

  4. Genetic deletion of osteopontin in TRAMP (show DPT Proteins) mice skews prostate carcinogenesis from adenocarcinoma to aggressive human-like neuroendocrine cancers.

  5. IFN-gamma (show IFNG Proteins) regulates hypertensive vascular collagen remodeling induced by ANG II (show AGT Proteins) and inhibits the differentiation of Th17 cells by suppressing OPN expression and regulating secretion of inflammatory cytokines.

  6. results indicate that autocrine OPN plays a crucial role in HPC expansion, migration, and subsequent oncogenic transformation of HPCs, which may provide a new insight into hepatocarcinogenesis

  7. OPN produced by hematogenous macrophages induces astrocyte process extension toward the infarct border zone, which may contribute to repair of the ischemic neurovascular unit following stroke

  8. During the priming phase of liver regeneration, osteopontin enhances the recruitment of macrophages and neutrophils, and triggers hepatocyte proliferation through Kupffer cell-derived IL-6 (show IL6 Proteins) release and the downstream activation of Stat3 (show STAT3 Proteins).

  9. OPN deficiency accelerated the spontaneous development of colitis in mice with disrupted gut (show GUSB Proteins) microbiota and macrophage phagocytic activity.

  10. mechanical stretch (MS) directly increased OPN protein expression and secretion in vascular smooth muscle cells.

Cow (Bovine) Secreted phosphoprotein 1 (SPP1) interaction partners

  1. This implies that a majority of the acidic residues within OPN must be engaged in calcium interaction under physiological conditions.

  2. Genetic variations in the SPP1 promoter affect gene expression and the level of osteopontin secretion into bovine milk.

  3. Osteopontin, osteocalcin and OB-cadherin expression in Synthetic nanohydroxyapatite vs bovine hydroxyapatite cultured Osteoblastic-like cells.

  4. osteopontin (OPN) can serve as a process-directing agent for the intrafibrillar mineralization of collagen.

  5. Results suggest a mechanism of the interaction of UO2(2+) with bone metabolism and a new role for osteopontin (OPN) as a metal transporter.

  6. Upon induction of luteolysis, SPP1 serves as a signaling molecule to recruit or activate immune cells to facilitate luteal regression and tissue degradation.

  7. OPN strongly reduces the amount of biofilm formed in a well-defined laboratory model of acidogenic dental biofilm.

  8. This study demonstrates that adhesion of isolated neonatal rat osteoclasts in vitro was augmented on bovine milk osteopontin (bmOPN) with post-translational modifications (PTMs) compared to human Escherichia-coli-derived recombinant OPN without PTMs.

  9. topographical distribution of both the in vivo and in vitro phosphorylation sites of bone sialoprotein (show CRISP1 Proteins)

  10. the bovine osteopontin gene has two functionally distinct clusters of haplotypes within the QTL region on chromosome 6

Rabbit Secreted phosphoprotein 1 (SPP1) interaction partners

  1. Infection of urinary tract by Escherichia coli caused higher than normal expression of promoter protein osteopontin and mucosal damage at renal tubular cells.

Osteopontin (SPP1) Protein Profile

Protein Summary

Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP1 catalyzes the degradation of S1P via salvage and recycling of sphingosine into long-chain ceramides (Mandala et al., 2000

Gene names and symbols associated with SPP1

  • secreted phosphoprotein 1 (spp1)
  • secreted phosphoprotein 1 (SPP1)
  • secreted phosphoprotein 1 (Spp1)
  • sphingosine-1-phosphate phosphatase 1 (Sgpp1)
  • sphingosine-1-phosphate phosphatase 1 (SGPP1)
  • 2AR protein
  • AI463453 protein
  • Apl-1 protein
  • BNSP protein
  • Bsp protein
  • BSPI protein
  • Eta protein
  • ETA-1 protein
  • OP protein
  • Opn protein
  • Opnl protein
  • OSP protein
  • Ric protein
  • SPP protein
  • Spp-1 protein
  • SPP1 protein
  • SPPase1 protein
  • Spph1 protein
  • zgc:111821 protein

Protein level used designations for SPP1

spp1 protein , osteopontin , SPP1/CALPHA1 fusion , early T-lymphocyte activation 1 , nephropontin , osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein , secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1) , urinary stone protein , uropontin , SPP-1 , bone sialoprotein 1 , 44 kDa bone phosphoprotein , calcium oxalate crystal growth inhibitor protein , early T-lymphocyte activation 1 protein , minopontin , osteopontin-like protein , Sialoprotein (osteopontin) , bone sialoprotein I , osteopontin-K , OC-1 , secreted phosphoprotein-1 , SPPase1 , sphingosine-1-phosphatase 1 , hSPP1 , hSPPase1 , spp1

432385 Danio rerio
6696 Homo sapiens
478471 Canis lupus familiaris
397087 Sus scrofa
20750 Mus musculus
25353 Rattus norvegicus
281499 Bos taurus
100008982 Oryctolagus cuniculus
395210 Gallus gallus
443058 Ovis aries
100860805 Capra hircus
81535 Mus musculus
81537 Homo sapiens
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