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SPR encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is important in the biosynthesis of tetrahydrobiopterin (BH4). Additionally we are shipping Sepiapterin Reductase Proteins (17) and Sepiapterin Reductase Kits (7) and many more products for this protein.
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Human Polyclonal SPR Primary Antibody for EIA, WB - ABIN954723
Leu-Semenescu, Arnulf, Decaix, Moussa, Clot, Boniol, Touitou, Levy, Vidailhet, Roze: Sleep and rhythm consequences of a genetically induced loss of serotonin. in Sleep 2010
Show all 3 references for ABIN954723
Human Polyclonal SPR Primary Antibody for ELISA, WB - ABIN562987
Balasubramanian, Deng, Doudney, Hampton, Kennedy: Valproic acid exposure leads to upregulation and increased promoter histone acetylation of sepiapterin reductase in a serotonergic cell line. in Neuropharmacology 2015
Human Polyclonal SPR Primary Antibody for WB - ABIN520456
Lange, Geerts, Feith, Mocz, Koster, Bachmann: Novel interaction of ornithine decarboxylase with sepiapterin reductase regulates neuroblastoma cell proliferation. in Journal of molecular biology 2014
Human Polyclonal SPR Primary Antibody for WB - ABIN653908
Maddens, Ghesquière, Vanholder, Demon, Vanmassenhove, Gevaert, Meyer: Chitinase-like proteins are candidate biomarkers for sepsis-induced acute kidney injury. in Molecular & cellular proteomics : MCP 2012
SPR-mediated reduction of sepiapterin and redox cycling occur by distinct mechanisms
biopterin contents in the brains of these knock-out mice were moderately decreased from postnatal day 0 (P0) and remained constant up to P21 (show D4S234E Antibodies)
These data suggest an essential role of SPR in the biosynthesis of BH4, and that the SPR gene could be a candidate gene for PARK3.
We showed that pretreating a cardiomyocyte cell line (H9C2) and a TNBC cell line (MDA-MB 231) with aprepitant, a SP receptor antagonist that is routinely used to treat chemotherapy-associated nausea, decreased DOX-induced reduction of viability, apoptotic cell death, and ROS (show ROS1 Antibodies) production in cardiomyocytes
These findings reveal important insight into the molecular mechanisms of the NK1R (show TACR1 Antibodies) complex as a critical component in a model of pediatric liver cancer and may support the development of novel therapeutic interventions for hepatoblastoma
Neuropeptide signaling through neurokinin-1 (show TAC1 Antibodies) and neurokinin-2 (show TAC1 Antibodies) receptors augments antigen presentation by human dendritic cells
Inhibition of CaV2.3 (show CACNA1E Antibodies) channels by NK1 (show CD160 Antibodies) receptors is sensitive to membrane cholesterol but insensitive to caveolin-1 (show CAV1 Antibodies).
We earlier presented evidence for a physical interaction between ODC (show ODC1 Antibodies) and SPR and we showed that RNAi-mediated knockdown of SPR expression significantly reduced native ODC (show ODC1 Antibodies) enzyme activity and impeded Neuroblastoma (show ARHGEF16 Antibodies) cell proliferation.
NK-1 (show CD160 Antibodies) activation could enhance EGFR (show EGFR Antibodies) expression and phosphorylation, and then activate EGFR (show EGFR Antibodies) related Erk/MAPK (show MAPK1 Antibodies) and Akt (show AKT1 Antibodies) pathway.
The single nucleotide polymorphisms in the TACR1 (show TACR1 Antibodies) gene are associated with sex differences in postoperative nausea and vomiting.
Results show the existence of a relevant alteration in NK-1R (show TACR1 Antibodies) expression in bipolar disorder patients and further suggest Substance P (show TAC1 Antibodies) involvement in BD.
Immunohistochemical NK-1R (show TACR1 Antibodies) and pEGFR positivity with VDR (show CYP27B1 Antibodies) negativity can be used to identify areas of sporadic colorectal neoplasia.
Hepatoblastoma cells predominantly expressed the truncated splice variant of NK1R (show TACR1 Antibodies).
this study demonstrates an important role of endothelial SPR in modulating tetrahydrobiopterin and nitric oxide bioavailability
This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P.
, Sepiapterin reductase
, short chain dehydrogenase/reductase family 38C, member 1
, 7,8-dihydrobiopterin:NADP+ oxidoreductase
, NK-1 receptor
, substance-P receptor
, tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor)
, neurokinin 1 receptor
, substance p receptor