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SEPT9 is a member of the septin family involved in cytokinesis and cell cycle control. Additionally we are shipping Septin 9 Antibodies (34) and many more products for this protein.
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SEPT9 promoter methylation and MN frequency, both measured in peripheral blood, occur at an early stage compared to carcinoma development, indicating that the approach might be suitable to monitor CRC (show CALR Proteins) development.
KRAS mutations and SEPT9 promoter methylation were present in 34% (29/85) and in 82% (70/85) of primary tumor tissue samples.
we demonstrate that SEPT9 negatively regulates EGFR (show EGFR Proteins) degradation by preventing the association of the ubiquitin ligase Cbl (show CBL Proteins) with CIN85 (show SH3KBP1 Proteins), resulting in reduced EGFR (show EGFR Proteins) ubiquitylation
provide a full overview of the theoretical basis, development, validation, and clinical applications of the SEPT9 assay for both basic science researchers and clinical practitioners
Results show that in plasma samples, elevated methylated SEPT9 (mSEPT9) values were detected in colorectal cancer, but not in adenomas. Tissue levels of mSEPT9 alone are not sufficient to predict mSEPT9 levels in plasma.
Authors report here that the septins SEPT2 (show SEPT2 Proteins), -9, -11, and probably -7 form fibrillar structures around the chlamydial inclusion.
Our results suggest that SEPT9 gene methylation is a valuable biomarker for screening CRC (show CALR Proteins) in the Chinese population
SEPT9 promoter methylation is detected in free circulating DNA of lung cancer patients
The study shows increased SEPT9 expression as a consequence of genomic amplification and is the first study to profile SEPT9_v1 through SEPT9_v7 isoform-specific mRNA expression in tumor and nontumor tissues from patients with breast cancer.
prognostic value of SHOX2 (show SHOX2 Proteins) and SEPT9 DNA methylation (show HELLS Proteins) in benign, paramalignant and malignant pleural effusions
The altered T-cell homeostasis caused by the loss of Sept9 results in an increase of CD8 (show CD8A Proteins)(+) central memory T-cells.
SEPT9 gene amplification and overexpression during mouse breast tumorigenesis
Data reveal the importance of Sept9 for septin (show SEPT6 Proteins) filament formation and general cell stability.
Zebrafish possess two genes, sept9a and sept9b that, like humans, express multiple transcripts.
This gene is a member of the septin family involved in cytokinesis and cell cycle control. This gene is a candidate for the ovarian tumor suppressor gene. Mutations in this gene cause hereditary neuralgic amyotrophy, also known as neuritis with brachial predilection. A chromosomal translocation involving this gene on chromosome 17 and the MLL gene on chromosome 11 results in acute myelomonocytic leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been described.
, MLL septin-like fusion protein MSF-A
, Ov/Br septin
, ovarian/breast septin
, septin D1
, MLL septin-like fusion
, SL3-3 integration site 1 protein
, eighth septin
, septin-like protein