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Shadow of Prion Protein Homolog (Zebrafish) Proteins (SPRN)

Prion-like protein that has PrP(C)-like neuroprotective activity. Additionally we are shipping SPRN Antibodies (38) and SPRN Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SPRN 212518 Q8BWU1
SPRN 503542 Q5BIV9
SPRN 541462 Q5BIV7
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Top SPRN Proteins at antibodies-online.com

Showing 8 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,113.83
Details
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$2,123.00
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$2,124.83
Details
Yeast Sheep His tag   1 mg Log in to see 56 to 66 Days
$2,159.67
Details
Yeast Gasterosteus aculeatus His tag   1 mg Log in to see 56 to 66 Days
$2,168.83
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,168.83
Details

SPRN Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human

Rat (Rattus)

More Proteins for Shadow of Prion Protein Homolog (Zebrafish) (SPRN) Interaction Partners

Mouse (Murine) Shadow of Prion Protein Homolog (Zebrafish) (SPRN) interaction partners

  1. Data suggest that expression of shadoo in neuron or hepatocyte cell lines induces same toxic phenotype of drug hypersensitivity as prion protein/PrP (show PRNP Proteins)(-central region); this effect is counteracted by co-expression of PrP-wild-type.

  2. No significant differences in survival, the incubation period of prion (show PRNP Proteins) disease or other disease features were observed between Sho mutant and WT mice

  3. These observations suggest that Shadoo can affect the prion (show PRNP Proteins) replication process by (i) acting as a holdase and (ii) interfering with the dominant-negative inhibitor effect of the C1 fragment.

  4. Data suggest that glycosylation status of the prion protein (show PRNP Proteins) and yet-to-be-dentified proteases modulate internal C1 and C2 endoproteolysis of Shadoo (shadow of prion protein) and Doppel (doppelganger (show PRND Proteins) prion (show PRNP Proteins)) in mouse neurons.

  5. binding of Sho to anionic liposomes has disruptive effect on integrity of lipid bilayer leading to formation of supramolecular lipid-protein complexes. prion (show PRNP Proteins) diseases might depend on the oligomerization state of Sho and on these lipoprotein assembles.

  6. Sho is not pi, or, given the accumulating data for many activities for PrP (C (show PRNP Proteins)) , the pi hypothesis invoking a discrete signaling pathway to maintain neuronal viability is no longer tenable.

  7. Here we report that Shadoo (Sho)-a member of the prion protein (show PRNP Proteins) superfamily-is also found in the nucleus of several neural and non-neural cell lines as visualized by using an YFP-Sho construct

  8. the Sho region N-terminal to the hydrophobic domain includes tandem positively charged "RGG boxes", predicted to bind RNA. Here, we demonstrate that Sho binds DNA and RNA in vitro via this arginine-rich region.

  9. using various Prnp (show PRNP Proteins) transgenic mouse lines and lentiviral vectors expressing shRNAs that target the Shadoo-encoding mRNA, we further demonstrate the specific requirement of at least one of these two PrP-related proteins at early developmental stages

  10. Knockout of the prion protein (PrP (show PRNP Proteins))-like Sprn gene does not produce embryonic lethality in combination with PrP(C (show PRNP Proteins))-deficiency.

Human Shadow of Prion Protein Homolog (Zebrafish) (SPRN) interaction partners

  1. Shadoo is degraded in Scrapie-infected rodents and cultured cells mediated by proteasome degradation after modification by ubiquitination.

  2. a conserved physiological activity between PrP(C (show PRNP Proteins)) and Sho to protect cells from stress-induced toxicity and suggests that Sho and PrP(C (show PRNP Proteins)) might act on similar signaling pathways.

  3. A novel solid phase technology for high- throughput synthesis of the SPRN gene is reported.

  4. Association of a null allele of SPRN with variant Creutzfeldt-Jakob disease

Cow (Bovine) Shadow of Prion Protein Homolog (Zebrafish) (SPRN) interaction partners

  1. Genetic characterization of PRNP (show PRNP Proteins) promoter indel variations and the polymorphism of open reading frames (ORFs) of PRNP (show PRNP Proteins) and bovine prion (show PRNP Proteins)-like Shadoo (SPRN) genes, are reported.

  2. Sho as a non-PrP (show PRNP Proteins) specific marker for prion (show PRNP Proteins) infections, with obex as the best tissue source for the detection of Sho in transmissible spongiform encephalopathies rapid tests.

  3. SPRN has the typical two-exon PRNP (show PRNP Proteins) arrangement, with the CDS (show ABHD5 Proteins) fully contained within exon 2; furthermore, it codes for a 143-amino-acid protein with 74.8% identity and 84.7% similarity with the human PRNP (show PRNP Proteins).

SPRN Protein Profile

Protein Summary

Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity).

Gene names and symbols associated with SPRN

  • shadow of prion protein (Sprn)
  • shadow of prion protein (sprn)
  • shadow of prion protein homolog (zebrafish) (SPRN)
  • shadow of prion protein homolog (zebrafish) (Sprn)
  • bA108K14.1 protein
  • C630041J07 protein
  • p12 protein
  • SHADOO protein
  • SHO protein
  • Sho1 protein
  • sprna protein

Protein level used designations for SPRN

Shadoo , protein shadoo , shadoo , shadow of prion protein 1 , hypothetical protein BC004409 , shadow of prion protein , shadoo protein Sho

GENE ID SPECIES
212518 Mus musculus
386702 Danio rerio
503542 Homo sapiens
541462 Rattus norvegicus
616266 Bos taurus
100302330 Ovis aries
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