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Shugoshin-Like 1 (S. Pombe) Proteins (SGOL1)

Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. Additionally we are shipping SGOL1 Antibodies (48) and SGOL1 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat SGOL1 SGOL1 363174  
SGOL1 151648 Q5FBB7
SGOL1 72415 Q9CXH7
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Top SGOL1 Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Schizosaccharomyces pombe His tag   1 mg Log in to see 56 to 66 Days
$2,856.33
Details
Yeast REACT_Maize/Corn His tag   1 mg Log in to see 56 to 66 Days
$3,336.67
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

SGOL1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Shugoshin-Like 1 (S. Pombe) (SGOL1) Interaction Partners

Human Shugoshin-Like 1 (S. Pombe) (SGOL1) interaction partners

  1. Cohesin complex (show SMC3 Proteins) is shown to be a target of the prophase pathway at centrosomes and protected by Sgo1-dependent PP2A (show PPP2R4 Proteins) recruitment.

  2. Sgo1 co-recruits Aurora B (show AURKB Proteins) and PP2A (show PPP2R4 Proteins) to centromeres of unattached chromosomes.

  3. Data indicate essential role of shugoshin-like protein 1 (Sgo1) in the maintenance of a proper mitotic progression in hepatoma cells and suggest that Sgo1 is a promising oncotarget for hepatocellular carcinoma (HCC (show FAM126A Proteins)).

  4. our findings strongly suggest that CIP2A (show KIAA1524 Proteins) promotes cell cycle progression, premature chromosome segregation, and aneuploidy, possibly through a novel interaction with Sgol1.

  5. Results show that Sgo1 is first recruited to kinetochores by H2A-pT120, and the kinetochore-bound Sgo1 is released by centromeric transcription.

  6. Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut (show GUSB Proteins) rhythm.

  7. Bub1 (show BUB1 Proteins)-mediated H2A phosphorylation penetrates kinetochores and that this histone mark contributes to a tension-sensitive Sgo1-based molecular switch for chromosome segregation.

  8. The most significant association with MaxDrinks was observed with SNP rs11128951 (p = 4.27 x 10(-8)) near SGOL1 gene at 3p24.3.

  9. Frameshift mutations of SGOL1 and PDS5B and the loss of their expression may be a feature of gastric and colorectal cancers with high microsatellite instability.

  10. SGO1 promotes multidrug resistance of gastric cancer cells and may be useful as a novel therapeutic target for preventing or reversing multidrug resistance

Mouse (Murine) Shugoshin-Like 1 (S. Pombe) (SGOL1) interaction partners

  1. Data show that compound mutant spindle assembly checkpoint components BubR1 (show BUB1B Proteins) and Sgo1 embryonic fibroblasts (MEFs) grew at a much slower rate, and a small fraction of cells exhibited morphologies of senescent cells at early passages.

  2. Study established the Sgo1 haploinsufficient mouse as a colon cancer model and identified antagonizing oncogenic and tumor-suppressing pathways that are differentially expressed and may be responsible for the different dynamics in the tumor development.

  3. Sgo1(-/+)-mediated ME-CIN (show PDXP Proteins) strongly promoted/progressed development of hepatocellular carcinoma in the presence of an initiator carcinogen, and it had a mild initiator effect by itself.

  4. Haploinsufficiency of SGO1 results in genomic instability manifested as missegregation of chromosomes and formation of extra centrosomal foci in both murine embryonic fibroblasts and adult bone marrow cells.

  5. It seems that Sgo1 sets up the centromeric protection mechanism in G2, but that its Bub1 (show BUB1 Proteins)-dependent localisation to centromeres during mitosis is not required to maintain cohesion.

  6. Prevention of premature separation of sister chromatids in meiosis I requires the retention of centromeric Sgo1, while normal separation of sister chromatids in meiosis II requires loss of centromeric Sgo1.

  7. report structure and function of the PP2A (show PPP2R2B Proteins)-shugoshin interaction.

SGOL1 Protein Profile

Protein Summary

Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the stag2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by espl1/separase at anaphase. May regulate kinetochore microtubule stability in mitosis, possibly to sense tension on mitotic chromosomes.

Gene names and symbols associated with SGOL1

  • shugoshin-like 1 (S. pombe) (Sgol1)
  • shugoshin centromeric cohesion1 (sgo1)
  • shugoshin-like 1 (sgol1)
  • shugoshin-like 1 (S. pombe) (SGOL1)
  • 3300001M08Rik protein
  • C81037 protein
  • NY-BR-85 protein
  • SGO protein
  • Sgo1 protein

Protein level used designations for SGOL1

AY109536_SNP , CL5684_1 , CL5684_1_ov , gnp_AW055587 , gpm134 , p-std614083G09 , shugoshin-1 , shugoshin-like protein , shugosin centromeric cohesion1 , std614083G09 , zmSGO1 , xsgo , hSgo1 , serologically defined breast cancer antigen NY-BR-85 , shugoshin 1AB protein , shugoshin 1CD protein , shugoshin 1EF protein , shugoshin 1GH protein , shugoshin 1KL protein , shugoshin-like 1 , shugoshin 1A protein

GENE ID SPECIES
363174 Rattus norvegicus
606461 Zea mays
735145 Xenopus laevis
151648 Homo sapiens
72415 Mus musculus
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