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Putative adhesion molecule. Additionally we are shipping SIGLEC14 Antibodies (32) and many more products for this protein.
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An unbiased screen revealed Hsp70 (show HSP70 Proteins) as a ligand for Siglec-5 (show SIGLEC5 Proteins) and Siglec-14. Hsp70 (show HSP70 Proteins) stimulation through Siglec-5 (show SIGLEC5 Proteins) delivers an anti-inflammatory signal, while stimulation through Siglec-14 is pro-inflammatory.
Genome-wide association analyses revealed common DNA variants in PLG (show PLG Proteins), LPA (show APOA Proteins), and near SIGLEC14 that contribute to plasma plasminogen (show PLG Proteins) level variation.
Data indicate that the Siglec-5 (show SIGLEC5 Proteins)/14 genotype influences neutrophil responses to group B Streptococcus.
Siglec-14 and its downstream signaling pathway facilitate the "infection-inflammation-exacerbation" axis of COPD (show ARCN1 Proteins) disease progression
Siglec-14 and Siglec-5 (show SIGLEC5 Proteins) appear to be the first glycan binding paired receptors. Near-complete sequence identity of the amino-terminal part of human Siglec-14 and Siglec-5 (show SIGLEC5 Proteins) indicates partial gene conversion between SIGLEC14 and SIGLEC5 (show SIGLEC5 Proteins).
The presence of the "SIGLEC14 null" allele in all human populations we tested implies an ancient origin, while its allelic frequency is higher in Asians compared with Africans and Europeans. Siglec-14 may play some role in bacterial infection.
Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors.
sialic acid-binding Ig-like lectin 14