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Binds sialylated glycoproteins.. Additionally we are shipping SIGLEC15 Antibodies (29) and many more products for this protein.
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Siglec-15 recognizes the tumoral sTn (show EEF1A2 Proteins) antigen and transduces a signal for enhanced TGF-beta (show TGFB1 Proteins) secretion in TAMs
Siglec-15 does not mediate joint destruction in inflammatory arthritis
The present findings indicate that Siglec-15 is involved in estrogen deficiency-induced differentiation of osteoclasts and is thus a potential therapeutic target for postmenopausal osteoporosis.
Siglec-15 regulates osteoclast development and bone resorption by modulating receptor activator of nuclear factor kappaB ligand (RANKL (show TNFSF11 Proteins)) signaling in association with DAP12 (show TYROBP Proteins).
DC-STAMP, Siglec-15, Tspan7 (show TSPAN7 Proteins) and Mst1r (show MST1R Proteins) expression was downregulated by docosahexaenoic acid, but not eicosapentaenoic acid during osteoclastogenesis in vitro.
results reveal the importance of Siglec-15 in the regulation of osteoclast formation and/or function in vivo, providing new insights into osteoclast biology
the Siglec-15-DAP12 (show TYROBP Proteins)-Syk (show SYK Proteins)-signaling cascade plays a critical role in functional osteoclast formation.
These results suggest that Siglec-15 plays an important role in osteoclast differentiation.
Binds sialylated glycoproteins.
sialic acid-binding Ig-like lectin 15
, CD33 antigen-like 3
, CD33 molecule-like 3