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SIRT7 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Additionally we are shipping Sirtuin 7 Proteins (15) and Sirtuin 7 Kits (12) and many more products for this protein.
Showing 10 out of 172 products:
Human Polyclonal SIRT7 Primary Antibody for IHC (p), WB - ABIN390182
Wang, Yi, Li, Cai, He, Ni, Zhou, Cheng, Jin, Fan, Qiu: Down-regulation of sirtuin 3 is associated with poor prognosis in hepatocellular carcinoma after resection. in BMC cancer 2014
Show all 3 references for 390182
Human Polyclonal SIRT7 Primary Antibody for IHC (fro), IF (p) - ABIN760571
Takumida, Takumida, Anniko: Localization of sirtuins in the mouse inner ear. in Acta oto-laryngologica 2014
Show all 2 references for 760571
Human Polyclonal SIRT7 Primary Antibody for WB - ABIN4353888
Alhazzazi, Kamarajan, Joo, Huang, Verdin, DSilva, Kapila: Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer. in Cancer 2011
Cow (Bovine) Polyclonal SIRT7 Primary Antibody for WB - ABIN2779623
Frye: Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. in Biochemical and biophysical research communications 2000
Human Polyclonal SIRT7 Primary Antibody for ICC, IF - ABIN259767
Zhang, Li, Deng, Liu, Chen, Tang, Wang, Cao, Fang, Wen, Xu, Chen, Shi, Li, Xie, Tang: Dicer interacts with SIRT7 and regulates H3K18 deacetylation in response to DNA damaging agents. in Nucleic acids research 2016
Cow (Bovine) Polyclonal SIRT7 Primary Antibody for WB - ABIN2779622
Ashraf, Zino, Macintyre, Kingsmore, Payne, George, Shiels: Altered sirtuin expression is associated with node-positive breast cancer. in British journal of cancer 2006
Data suggest that SIRT7 undergoes Lys (show LYZ Antibodies)-63 polyubiquitination, later removed by USP7 (show USP7 Antibodies) to repress enzymatic activity of SIRT7; USP7 (show USP7 Antibodies) and SIRT7 regulate gluconeogenesis via expression of glucose-6-phosphatase catalytic subunit (G6PC (show G6PC Antibodies)); SIRT7 targets G6PC (show G6PC Antibodies) promoter through ELK4 (show ELK4 Antibodies). (SIRT7 = sirtuin 7; USP7 (show USP7 Antibodies) = ubiquitin specific peptidase 7 (show USP7 Antibodies); G6PC (show G6PC Antibodies) = glucose-6-phosphatase catalytic subunit (show G6PC Antibodies); ELK4 (show ELK4 Antibodies) = transcription factor ELK4 (show ELK4 Antibodies))
the decline in SIRT7 in lung fibroblasts has a profibrotic effect, which is mediated by changes in Smad3 (show SMAD3 Antibodies) levels.
SIRT7 inhibits TR4 (show NR2C2 Antibodies) degradation by deacetylation of DDB1 (show DDB1 Antibodies).
miR (show MLXIP Antibodies)-152/SIRT7 axis plays a key role in the regulation of Human dental pulp stem cell senescence.
our study suggests that SIRT7 functions as an oncogene (show RAB1A Antibodies) in non-small cell lung cancer (NSCLC), and miR (show MLXIP Antibodies)-3666 can target SIRT7 to inhibit NSCLC cell growth by promoting the pro-apoptotic signaling pathway
SIRT7 trans-represses RPS7 (show RPS7 Antibodies) gene in the presence of HBx protein.HBx enhances intracellular stability of SIRT7 protein.
Data indicate that compared to non-neoplastic endometria (NNE (show ENO1 Antibodies)), endometrial cancer (EC) showed SIRT7 mRNA overexpression, whereas SIRT1 (show SIRT1 Antibodies), SIRT2 (show SIRT2 Antibodies), SIRT4 (show SIRT4 Antibodies) and SIRT5 (show SIRT5 Antibodies) were underexpressed, and no significant differences were observed for SIRT3 (show SIRT3 Antibodies) and SIRT6 (show SIRT6 Antibodies).
This study showed that SIRT7 can be activated by DNA to hydrolyze the acetyl group from lysine residues in vitro on histone peptides and histones in the chromatin context.
Novel interactions of TPPII (show Tpp2 Antibodies), p53 (show TP53 Antibodies), and SIRT7 presented in this study might contribute to the knowledge of the regulatory effects of these proteins on apoptotic pathways and to the understanding mechanisms of aging and lifespan regulation.
SIRT7 deacetylates U3-55k (show RRP9 Antibodies), enhancing U3-55k (show RRP9 Antibodies) binding to U3 snoRNA, which is a prerequisite for pre-rRNA processing.
These results reveal a direct role for SIRT7 in double-strand break repair and establish a functional link between SIRT7-mediated histone H3 (show HIST3H3 Antibodies) K18 (show KRT18 Antibodies) deacetylation and the maintenance of genome integrity.
miR (show MLXIP Antibodies)-93 inhibits the metabolic target Sirt7, which we identified as a major driver of in vivo adipogenesis via induction of differentiation and maturation of early adipocyte precursors.
The role of SIRT7 has emerged in protein synthesis, chromatin remodelling, cellular survival and lipid metabolism.
SIRT7 stabilizes and activates the GABP alpha (show GABPA Antibodies)/GABPbeta complex via deacetylation of GABPbeta1.
SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway.
Study identifies SIRT7 as a cofactor of Myc (show MYC Antibodies) for transcriptional repression and delineates a druggable regulatory branch of the ER stress response that prevents and reverts fatty liver disease.
Mybbp1a (show MYBBP1A Antibodies) is a novel negative regulator of Sirt7.
SirT7 plays a dominant role in the growth inhibition of the P19 (show CDKN2D Antibodies) cells.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae)
, sirtuin 7
, novel protein similar to vertebratesirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae) (SIRT7)
, NAD-dependent deacetylase sirtuin-7
, NAD-dependent protein deacetylase sirtuin-7
, SIR2-like protein 7
, regulatory protein SIR2 homolog 7
, silent mating type information regulation 2, S.cerevisiae, homolog 7
, sir2-related protein type 7
, sirtuin type 7
, NAD-dependent deacetylase sirtuin 7