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acts as a ligand for glypican-1, a heparan sulfate proteoglycan; may play a role in neurogenesis and midline development. Additionally we are shipping Slit Homolog 2 (Drosophila) Antibodies (81) and Slit Homolog 2 (Drosophila) Proteins (12) and many more products for this protein.
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Human SLIT2 ELISA Kit for Sandwich ELISA - ABIN414767
Bauer, Dowejko, Bosserhoff, Reichert, Bauer: Slit-2 facilitates interaction of P-cadherin with Robo-3 and inhibits cell migration in an oral squamous cell carcinoma cell line. in Carcinogenesis 2011
Show all 4 references for ABIN414767
These data supports a model whereby Wnt signaling through Frizzled-3a attenuates expression of Slit2 in the rostral midline of the forebrain.
In embryonic axon tracts, Robo2 (show ROBO2 ELISA Kits) responds to signals from slit2 and slit3 (show SLIT3 ELISA Kits).
Data show that Hedgehog (show SHH ELISA Kits) signaling is required for commissure formation, glial bridge formation, and the restricted expression of the guidance molecules slit1a, slit2, slit3 (show SLIT3 ELISA Kits) and sema3d (show SEMA3D ELISA Kits).
Slit acts via Robo2 (show ROBO2 ELISA Kits) in dendrites as a branching/growth factor but not in guidance, while Robo2 (show ROBO2 ELISA Kits) and Robo3 (show ROBO3 ELISA Kits) function in concert in axons to mediate axonal interactions and respond to Slits as guidance factors
Study shows that Slit2 (show SLIT3 ELISA Kits) mRNA and protein levels were significantly reduced in papillary thyroid cancer (PTC (show F9 ELISA Kits)) specimens and implicates Slit2 (show SLIT3 ELISA Kits) functions as a negative regulator in the development and progression of PTC (show F9 ELISA Kits).
Overexpression of Slit2 induces its tumor suppressive effects in Breast cancer.
Significantly increased serum Slit2 (show SLIT3 ELISA Kits) levels and hepatic expression of Slit2 (show SLIT3 ELISA Kits) and Robo1 (show ROBO1 ELISA Kits) were observed in patients with liver fibrosis.
our findings indicated that Slit2 (show SLIT3 ELISA Kits)/Robo1 (show ROBO1 ELISA Kits) axis possibly be regarded as a significant clinical parameter for predicting brain metastasis in breast cancer patients.
These results suggest that Slit2/Robo1 binding exerts an effect on cell migration, which is negatively regulated by Robo4, and Robo1 may function by interacting with CdGAP in HUVECs.
VEGFR2 (show KDR ELISA Kits) activation was not affected by Slit2 (show SLIT3 ELISA Kits), but eNOS (show NOS3 ELISA Kits) phosphorylation was diminished
Slit2-exon 15 splicing variants have different roles in angiogenesis and HUVEC permeability
Data indicate that SLIT2 (show SLIT3 ELISA Kits), miR (show MLXIP ELISA Kits)-218-1, RET (show RET ELISA Kits)/PLAG1 (show PLAG1 ELISA Kits) and SLIT2 (show SLIT3 ELISA Kits)/ROBO1 (show ROBO1 ELISA Kits) pathway involved in Hirschsprung's disease.
Slit2 (show SLIT3 ELISA Kits)/Robo1 (show ROBO1 ELISA Kits) signaling promotes intestinal tumorigenesis through Src (show SRC ELISA Kits)-mediated activation of the Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) pathway.
In this review, we summarize recent findings demonstrating that the neuronal guidance cues, Slit and Roundabout (show ROBO1 ELISA Kits) (Robo), prevent the migration of multiple leukocyte subsets towards diverse inflammatory chemoattractants.
In mice with oxygen-induced retinopathy (OIR), the expression level of miR-218 was significantly downregulated. Robo1 expression was suppressed by miR-218. Furthermore, in the mice with OIR, the expression level of miR-218 was significantly downregulated, and that of miR-218-1 and its host gene, Slit2, was concomitantly downregulated as well.
Slit2 induces a robust activation of PKA signaling, which is required for its prothermogenic activity.
Robo1-Slit2 interaction required for pathfinding mechanism essential to establish the functionally important habenulo-interpeduncular connection.
Together, these observations suggest that Slit2 serves as a factor utilized by muscle Ctnnb1 (show CTNNB1 ELISA Kits) to direct presynaptic differentiation.
Slit2 acts as a repellant cue to mediate axon guidance in the formation of the anterior commissure.
Slit2/Robo1 (show ROBO1 ELISA Kits) signaling promotes intestinal tumorigenesis through Src (show SRC ELISA Kits)-mediated activation of the Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) pathway.
the two genes neuropeptide Y (Npy (show NPY ELISA Kits)) and Slit homolog 2 (Drosophila) (Slit2) gradually increase during aging, and upon suppression of these two genes
Data shows that modulation of angiostatic factor Slit2 by EphA2 receptor regulates endothelial responses to VEGF-mediated angiogenesis and tumor neovascularization.
administration of Slit2 to atherosclerosis-prone LDL receptor (show LDLR ELISA Kits)-deficient mice inhibited monocyte recruitment to nascent atherosclerotic lesions.
Results provide novel evidence that low expression of SLIT2 correlates with poor prognosis and promotes metastasis in ESCC, which may be regulated by the Cdc42 (show CDC42 ELISA Kits)-mediated pathways.
acts as a ligand for glypican-1, a heparan sulfate proteoglycan\; may play a role in neurogenesis and midline development
slit homolog 2 protein
, downregulated during adipocyte differentiation-1
, neurogenic extracellular slit protein