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Sodium Channel, Voltage-Gated, Type III, alpha Subunit Proteins (SCN3A)

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. Additionally we are shipping Sodium Channel, Voltage-Gated, Type III, alpha Subunit Antibodies (34) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse SCN3A SCN3A 20269  
Rat SCN3A SCN3A 497770 P08104
SCN3A 6328 Q9NY46
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Top Sodium Channel, Voltage-Gated, Type III, alpha Subunit Proteins at antibodies-online.com

Showing 2 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

SCN3A Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,

More Proteins for Sodium Channel, Voltage-Gated, Type III, alpha Subunit (SCN3A) Interaction Partners

Mouse (Murine) Sodium Channel, Voltage-Gated, Type III, alpha Subunit (SCN3A) interaction partners

  1. a huge difference in electrophysiological function between SCN1A (show SCN1A Proteins) and SCN3A mutations in the pore region; this might explain the more common SCN1A (show SCN1A Proteins) mutations detected in patients with epilepsy and the more severe phenotypes associated with these mutations

  2. these findings suggest that CpG methylation and MBD2 are involved in altering Scn3a expression during postnatal development and seizure condition.

  3. These results suggest that the GC box and CpG methylation might play important roles in regulating mouse Scn3a gene expression.

  4. These data demonstrate that Nav1.3 is neither necessary nor sufficient for the development of nerve-injury related pain.

  5. SCN2A (show SCN2A Proteins), SCN3A, and SCN9A (show SCN9A Proteins) are expressed beneath tight junctions in subsets of taste cells. SCN3A and SCN9A (show SCN9A Proteins) are expressed in TRPM5 (show TRPM5 Proteins) cells, while SCN2A (show SCN2A Proteins) was expressed in TRPM5 (show TRPM5 Proteins) and PKD2L1 (show PKD2L1 Proteins) cells.

Human Sodium Channel, Voltage-Gated, Type III, alpha Subunit (SCN3A) interaction partners

  1. Discovery of a common biophysical defect among variants identified in unrelated pediatric epilepsy patients suggests that SCN3A may contribute to neuronal hyperexcitability and epilepsy.

  2. Our data from the Hong Kong and Malaysia cohorts showed no significant allele, genotype and haplotype association of polymorphisms in the SCN1A (show SCN1A Proteins), SCN2A (show SCN2A Proteins), and SCN3A genes with drug responsiveness in epilepsy.

  3. This study demonistrated that associated with a duplication of the SCN2A (show SCN2A Proteins) and SCN3A gene cluster on 2q24 in patient with early onset epilepsy.

  4. Upregulation of Nav1.3 protein and a specific cellular distribution of Nav1.3 proteins in focal cortical dysplasia type IIb(FCDIIb) lesion tissue samples suggest that Nav1.3 may be involved in the generation of epileptic activity in FCDIIb.

  5. Deletions in SCN3A gene is associated with autistic features and developmental delay.

  6. In trigeminal neuralgia (TN) there is a reduction in the expression of Nav1.7 (show SCN9A Proteins) and an increase in the expression of Nav1.3, Nav1.8 (show SCN10A Proteins) expression not significantly different; TN can be, at least in part, a channelopathy.

  7. in autism families, two polymorphic coding variants of SCN3A are described

  8. Characterization of 5' untranslated regions SCN3A, and identification of cis (show CISH Proteins)-conserved noncoding sequences.

Sodium Channel, Voltage-Gated, Type III, alpha Subunit (SCN3A) Protein Profile

Protein Summary

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SCN3A

  • sodium channel, voltage-gated, type III, alpha subunit (SCN3A)
  • sodium channel, voltage-gated, type III, alpha subunit (scn3a)
  • sodium channel, voltage-gated, type III, alpha (Scn3a)
  • Gm1000 protein
  • NAC3 protein
  • Nav1.3 protein
  • SCIII protein
  • Scn2a protein
  • SCN3A protein

Protein level used designations for SCN3A

sodium channel, voltage-gated, type III, alpha subunit , sodium channel, voltage-gated, type III, alpha polypeptide , sodium channel protein brain III subunit alpha , sodium channel protein type 3 subunit alpha , sodium channel protein type III subunit alpha , sodium channel protein, brain III subunit alpha , sodium channel, voltage-gated, type 3, alpha subunit , voltage-gated sodium channel subtype III , voltage-gated sodium channel subunit alpha Nav1.3 , brain III voltage-gated sodium channel , voltage-dependent sodium channel SCN3A

GENE ID SPECIES
459699 Pan troglodytes
478772 Canis lupus familiaris
100125099 Xenopus (Silurana) tropicalis
100180733 Ciona intestinalis
20269 Mus musculus
497770 Rattus norvegicus
6328 Homo sapiens
424180 Gallus gallus
534223 Bos taurus
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