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Sodium Channel, Voltage-Gated, Type VIII, alpha Proteins (SCN8A)

SCN8A encodes a member of the sodium channel alpha subunit gene family. Additionally we are shipping SCN8A Antibodies (52) and SCN8A Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SCN8A 6334 Q9UQD0
Rat SCN8A SCN8A 29710 O88420
SCN8A 20273 Q9WTU3
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Top SCN8A Proteins at antibodies-online.com

Showing 3 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

SCN8A Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Sodium Channel, Voltage-Gated, Type VIII, alpha (SCN8A) Interaction Partners

Human Sodium Channel, Voltage-Gated, Type VIII, alpha (SCN8A) interaction partners

  1. the calpain-dependent cleavage of Nav1.6 channels expressed in human embryonic kidney (HEK) 293 cells caused the upregulation of I(NaP)

  2. Our study establishes SCN8A as a novel gene in which a recurrent mutation causes BFIS/ICCA (show PRRT2 Proteins), expanding the clinical-genetic spectrum of combined epileptic and dyskinetic syndromes.

  3. Human Nav1.6 channels generate larger resurgent currents than human Nav1.1 (show SCN1A Proteins) channels, but the SCN4B (show SCN4B Proteins)-derived Navbeta4 (show SCN4B Proteins) peptide does not protect either isoform from use-dependent reduction.

  4. These data strengthen previous findings linking gain-of-function mutations of SCN8A with EIEE and demonstrate the importance of functional testing in establishing the pathogenicity of de novo mutations.

  5. Expression profiling of SCN8A and NDUFC2 (show NDUFC2 Proteins) genes in colorectal carcinoma is reported. There was no NDUFC2 (show NDUFC2 Proteins) differential expression in colorectal carcinoma.

  6. Epileptic encephalopathy related to mutations in the SCN8A genes.

  7. SCN8A encephalopathy presents in infancy with multiple seizure types.

  8. The results of this study suggested that SCN8A mutation cause early onset epilepsy and intellectual disability.

  9. identified the PI3K/Akt pathway, the cell-cycle regulator Wee1 kinase, and protein kinase C (PKC) as prospective regulatory nodes of neuronal excitability through modulation of the FGF14:Nav1.6 complex.

  10. Data support the contribution of gain-of-function mutations of Nav1.6 (de novo variant p.Thr767Ile) that increase excitatory pyramidal neuron excitability

Mouse (Murine) Sodium Channel, Voltage-Gated, Type VIII, alpha (SCN8A) interaction partners

  1. the presences of Nav1.1 (show SCN1A Proteins), Nav1.6, Navbeta1 and Navbeta3 mRNA and their reduced levels in rat SAN during aging.

  2. This study demonstrates that Nav channel expression in lumbar motoneurons is altered after SCI, and it shows a tight relationship between the calpain-dependent proteolysis of Nav1.6 channels, the upregulation of I(NaP (show CTNNBL1 Proteins)) and spastici

  3. the role of Nav1.6 in general anesthesia using two mouse mutants with reduced activity of Nav1.6, was examined.

  4. observed increased hippocampal pyramidal cell excitability in heterozygous and homozygous Scn8a-R1627H mutants, and decreased interneuron excitability in heterozygous Scn8a-R1627H mutants.

  5. The data support a model where ankyrinG-binding is required for preferential Nav1.6 insertion into the axon initial segment plasma membrane during development.

  6. the degenerating muscle mutation is a loss of function mutation of scn8a

  7. N1768D mutation of SCN8A is sufficient to induce seizures and SUDEP in knock-in mice.

  8. APP (show APP Proteins) enhances Nav1.6 sodium channel cell surface expression through a Go-coupled JNK (show MAPK8 Proteins) pathway

  9. This study provided evidence for a direct link between sodium channel activity and modulation of Rac1 and ERK1/2 activation in ATP-stimulated microglia, possibly by regulating Ca(2 (show CA2 Proteins)+) transients

  10. results identify the hippocampus as an important structure in the mediation of Scn8a-dependent seizure protection and suggest that selective targeting of Scn8a activity might be efficacious in patients with epilepsy.

SCN8A Protein Profile

Protein Summary

This gene encodes a member of the sodium channel alpha subunit gene family. The encoded protein forms the ion pore region of the voltage-gated sodium channel. This protein is essential for the rapid membrane depolarization that occurs during the formation of the action potential in excitable neurons. Mutations in this gene are associated with mental retardation, pancerebellar atrophy and ataxia. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with SCN8A

  • sodium channel, voltage gated, type VIII, alpha subunit (SCN8A)
  • sodium channel, voltage gated, type VIII, alpha subunit (Scn8a)
  • sodium channel, voltage-gated, type VIII, alpha (Scn8a)
  • AI853486 protein
  • C630029C19Rik protein
  • CERIII protein
  • CIAT protein
  • dmu protein
  • EIEE13 protein
  • med protein
  • mnd-2 protein
  • mnd2 protein
  • NaCh6 protein
  • Nav1.6 protein
  • nmf2 protein
  • nmf58 protein
  • nmf335 protein
  • nur14 protein
  • PN4 protein
  • seal protein

Protein level used designations for SCN8A

hNa6/Scn8a voltage-gated sodium channel , sodium channel protein type 8 subunit alpha , voltage-gated sodium channel subunit alpha Nav1.6 , Na+ channel , PN4 , naCh6 , peripheral nerve protein type 4 , sodium channel 6 , sodium channel protein type VIII subunit alpha , sodium channel voltage-gated type VIII alpha polypeptide , sodium channel, voltage-gated, type 8, alpha polypeptide , sodium channel, voltage-gated, type 8, alpha subunit , sodium channel, voltage-gated, type VIII, alpha polypeptide , ataxia 3

GENE ID SPECIES
6334 Homo sapiens
477604 Canis lupus familiaris
29710 Rattus norvegicus
537277 Bos taurus
20273 Mus musculus
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