Sodium Channel, Voltage-Gated, Type IX, alpha Subunit Proteins (SCN9A)

SCN9A encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Additionally we are shipping SCN9A Antibodies (98) and SCN9A Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SCN9A 20274  
Rat SCN9A SCN9A 78956 O08562
SCN9A 6335 Q15858
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Top SCN9A Proteins at antibodies-online.com

Showing 5 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
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HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details

SCN9A Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

Human , ,
,

More Proteins for Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) Interaction Partners

Cow (Bovine) Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) interaction partners

  1. TNF-alpha (show TNF Proteins) up-regulates NaV1.7 mRNA in both adrenal chromaffin cells and dorsal root ganglia (DRG) neurons, highlighting the peripheral nociceptive mechanism of TNF-alpha (show TNF Proteins)

  2. Findings suggest that the endothelin-1 (show EDN1 Proteins)-induced down-regulation of NaV1.7 (SCN9A) diminishes NaV1.7-related catecholamine secretion and dephosphorylation of tau.

  3. Nav1.7-Ca2 (show CA2 Proteins)+ influx-induced increased phosphorylations of extracellular signal-regulated kinase (ERK (show MAPK1 Proteins)) and p38 (show MAPK14 Proteins) attenuate tau phosphorylation via glycogen synthase kinase-3beta: priming of Nav1.7 gating by ERK (show MAPK1 Proteins) and p38 (show MAPK14 Proteins)

  4. constitutively phosphorylated/activated ERK (show MAPK1 Proteins) destabilizes Na(+) channel alpha-subunit (show POLG Proteins) mRNA via translational event, which negatively regulates steady-state level of alpha-subunit (show POLG Proteins) mRNA and cell surface expression of functional Na(+) channels.

  5. Na influx via scn9a converged on inhibitory phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation

Mouse (Murine) Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) interaction partners

  1. Voltage-gated sodium channel Nav1.7 controls the efficacy and balance of heterotrimeric guanine nucleotide-binding protein-coupled receptor (GPCR)-mediated pro- and antinociceptive intracellular signaling.

  2. the FGF13 (show FGF13 Proteins)/Nav1.7 complex is essential for sustaining the transmission of noxious heat signals

  3. this paper shows that Nav1.7, by coupling with CRMP1 (show CRMP1 Proteins), mediates the axonal retrograde signaling of Sema3A (show SEMA3A Proteins) in axonal guidance

  4. Experiments show that integration of synaptic inputs over time by Nav1.7 is critical for body weight regulation and reveal a mechanism for synaptic control of circuits regulating long term homeostatic functions.

  5. Nav1.7 deletion has profound effects on gene expression, leading to an upregulation of enkephalin precursor Penk (show PENK Proteins) mRNA and met-enkephalin protein in sensory neurons.

  6. Global Nav1.7 knockouts showed no defects in mechanical sensitivity or overall movement yet were completely insensitive to painful tactile, thermal, and chemical stimuli and were anosmic.

  7. Sodium channel Nav1.7, encoded by SCN9A, is expressed in DRG neurons and regulates their excitability.

  8. a novel regulatory mechanism that utilizes CRMP2 (show DPYSL2 Proteins) SUMOylation to choreograph NaV1.7 trafficking.

  9. Behavioural deficits in Nav1.7/Nav1.8 (show SCN10A Proteins) knockout mice reflects a failure of action potential propagation in a mechanosensitive set of sensory neurons rather than a loss of primary transduction currents.

  10. Deleting SCN9A in both sensory and sympathetic neurons abolishes pain sensations.

Human Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) interaction partners

  1. Genetic polymorphisms of SCN9A are associated with protection for severe neuropathy induced by oxaliplatin in digestive cancer.

  2. the results of this study provide mechanistic evidence for a time-dependent increase in intracellular [Ca2 (show CA2 Proteins)+]i and energetic compromise in the neurites of dorsal root ganglia neurons expressing G856D mutant Nav1.7 channels.

  3. the FGF13 (show FGF13 Proteins)/Nav1.7 complex is essential for sustaining the transmission of noxious heat signals

  4. This study showed that gain-of-function attributes at the channel level and differential effects of physiologically relevant thermal stimuli on the excitability of DRG neurons expressing mutant and WT Nav1.7 channels, suggesting a cellular mechanism for warmth-triggered pain episodes in Erythromelalgia patients.

  5. The four congenital insensitivity to pain families, while not closely related, belong to the same ethnic group and clan (show NLRC4 Proteins), and the SCN9A mutation may be specific, if not unique to this group

  6. A novel Nav1.9 (show SCN11A Proteins) mutation, p.Arg222His, was identified in patients with early-onset pain in distal extremities including joints and gastrointestinal disturbances, but was absent from an asymptomatic blood relative.

  7. Gain-of-function mutation of a voltage-gated sodium channel NaV1.7 associated with peripheral pain and impaired limb development

  8. Results indicate that Nav 1.7 promotes gastric cancer progression through MACC1 (show MACC1 Proteins)-mediated upregulation of NHE1 (show SLC9A1 Proteins).

  9. report the engineering of highly potent and selective inhibitors of the Nav1.7 channel based on tarantula ceratotoxin-1 (CcoTx1). We utilized a combination of directed evolution, saturation mutagenesis, chemical modification, and rational drug design to obtain higher potency and selectivity to the Nav1.7 channel

  10. Mutant cycle analysis with modified saxitoxins reveals specific interactions critical to attaining high-affinity inhibition of human NaV1.7.

SCN9A Protein Profile

Protein Summary

This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder.

Gene names and symbols associated with SCN9A

  • sodium channel, voltage-gated, type IX, alpha subunit (SCN9A)
  • sodium channel, voltage-gated, type IX, alpha (Scn9a)
  • DKFZp459G084 protein
  • ETHA protein
  • FEB3B protein
  • GEFSP7 protein
  • mKIAA4197 protein
  • Nav1.7 protein
  • NE-NA protein
  • NENA protein
  • PN1 protein
  • Scn2a protein
  • SCN9A protein
  • SFNP protein

Protein level used designations for SCN9A

sodium channel, voltage-gated, type IX, alpha subunit , sodium channel protein type 9 subunit alpha-like , peripheral sodium channel 1 , sodium channel 25 , sodium channel protein type 9 subunit alpha , sodium channel protein type IX subunit alpha , sodium channel, voltage-gated, type IX, alpha polypeptide , voltage-gated sodium channel alpha subunit Nav1.7 , voltage-gated sodium channel subunit alpha Nav1.7 , sodium channel, voltage-gated, type 9, alpha polypeptide , hNE-Na , neuroendocrine sodium channel , nas , schwann cell sodium channel , sodium channel alpha-subunit

GENE ID SPECIES
488381 Canis lupus familiaris
533065 Bos taurus
100016648 Monodelphis domestica
100172961 Pongo abelii
100385702 Callithrix jacchus
100482886 Ailuropoda melanoleuca
100516701 Sus scrofa
100583836 Nomascus leucogenys
20274 Mus musculus
78956 Rattus norvegicus
6335 Homo sapiens
100009210 Oryctolagus cuniculus
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