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The protein encoded by SLC10A1 belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Additionally we are shipping SLC10A1 Kits (6) and SLC10A1 Proteins (4) and many more products for this protein.
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NTCP and OATP (show SLCO1A2 Antibodies) isoforms cooperatively form a stable bile acid uptake machinery in mice, whereas NTCP is predominant in humans.
Isoniazid/rifampicin administration significantly down-regulated the expression of hepatic bile acids transporters Ntcp and Bsep (show ABCB11 Antibodies) in liver.
Ntcp plasma membrane localization is regulated by hyperosmolarity and tauroursodeoxycholate
hepatic transporters Ntcp and Mrp2 (show ABCC2 Antibodies) are downregulated in rodent models of necrotizing enterocolitis
Large variations in hepatic bile salt flux have minor effects on expression of murine Ntcp and Bsep (show ABCB11 Antibodies) in vivo, suggesting that these transporters are abundantly expressed and able to accommodate a wide range of 'physiological' bile salt fluxes.
Conserved NTCP/Ntcp 5'-regulatory region transcription regulation differs among species and is not directly regulated by small heterodimer partner (show NR0B2 Antibodies). Bile acids may regulate NTCP/Ntcp indirectly by modulating nuclear factor regulation of gene expression.
Reduced levels of HNF-1alpha (show HNF1A Antibodies), RXRalpha (show RXRA Antibodies), and RARalpha (show RARA Antibodies) in CBDL FXR (show NR1H4 Antibodies)-/- mice and reduced DNA binding in CA-fed FXR (show NR1H4 Antibodies)-/- mice, despite unchanged Ntcp levels, indicate that these factors may have a minor role in regulation of mouse Ntcp during cholestasis
The C51A and C106A mutants of Slc10a2 (show SLC10A2 Antibodies) showed significantly reduced TCA uptake, while no apparent difference in TCA uptake was observed for the Slc10a1-C44A (show LYPD3 Antibodies) mutant.
Ntcp and Bsep (show ABCB11 Antibodies) are regulated by age, gender, cholestyramine, and bile acid, but resistant to induction by most microsomal enzyme inducers.
mouse Ntcp is regulated by HNF-4alpha (show HNF4A Antibodies) via a conserved distal cis (show CISH Antibodies)-element independently of HNF-1alpha (show HNF1A Antibodies).
For Tibetans and Uygurs, no association of the three NTCP SNPs (rs7154439, rs4646287 and rs2296651) and their haplotypes with hepatitis B virus chronicity was observed.
the present study indicated that the common variants in the regulatory elements of NTCP may not influence the expression level of SLC10A1 at transcriptional regulation, and ultimately may not be associated with HBV susceptibility.
The data showed that S267F of sodium taurocholate cotransporting polypeptide is not associated with hepatitis B virus infection, and is not prevalent in the general Moroccan population.
The SLC10A1 (NTCP) S267F variant is independently associated with decreased risk of progression to Liver cirrhosis and Hepatocellular Carcinoma , and resistance to Chronic Hepatitis B infection.
In conclusion, NTCP appeared inefficient to mediate infection by serum-derived hepatitis B virus.
Computer screening of NTCP inhibitors and non-inhibitors showed no relationship between the drugs and drug induced liver injury.
We found a genetic variant (rs4646287) located in intron 1 of NTCP that may be associated with increased risk of HBV infection in Han Chinese
The observation that the pharmacological inhibitors of the NTCP transporter could block HBV entry suggests that NTCP represents an attractive molecular target for therapeutic intervention in HBV infection.
Hepatitis B virus efficiently infects non-adherent hepatoma cells via NTCP, which functions as a virus receptor.
This study suggests that polymorphisms in the NTCP region may be associated with the natural course of HBV infection.
The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids\; the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes. Bile acids are the catabolic product of cholesterol metabolism, hence this protein is important for cholesterol homeostasis.
Na(+)/bile acid cotransporter
, Na(+)/taurocholate transport protein
, bile acid cotransporting polypeptide
, sodium bile acid cotransporting polypeptide
, sodium-taurocholate cotransporting polypeptide
, sodium/bile acid cotransporter
, sodium/taurocholate cotransporting polypeptide
, Na/taurocholate cotransporting polypeptide
, cell growth-inhibiting gene 29 protein
, growth-inhibiting protein 29
, sodium/taurocholate cotransporter
, solute carrier family 10 (sodium/bile acid cotransporter family), member 1
, solute carrier family 10 member 1
, NA-dependent cholate transporting protein
, sodium-dependent bile acid cotransporter
, sodium-dependent taurocholate cotransporting polypeptide
, solute carrier family 10, member 1