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Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 2 Proteins (SLC11A2)

SLC11A2 encodes a member of the solute carrier family 11 protein family. Additionally we are shipping Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 2 Antibodies (85) and Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 2 Kits (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat SLC11A2 SLC11A2 25715 O54902
SLC11A2 4891 P49281
SLC11A2 18174 P49282
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Top Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 2 Proteins at antibodies-online.com

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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
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Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
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HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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SLC11A2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 2 (SLC11A2) Interaction Partners

Zebrafish Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 2 (SLC11A2) interaction partners

  1. The zebrafish mutant gene chardonnay (cdy) encodes divalent metal transporter 1 (DMT1). Whereas wild-type zebrafish DMT1 protein can transport iron, the truncated protein expressed in cdy mutants is not functional.

Human Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 2 (SLC11A2) interaction partners

  1. Gene silencing of either CTR1 (show SLC31A1 Proteins) or DMT1 (show DMRT1 Proteins) did not affect copper accumulation in cells, but deficiency in both CTR1 (show SLC31A1 Proteins) and DMT1 (show DMRT1 Proteins) resulted in a complete inhibition of copper uptake.

  2. These data suggest that iron uptake induces the production of ROS (show ROS1 Proteins), which modify DMT1 (show DMRT1 Proteins) endocytic cycling, thus changing the iron transport activity at the apical membrane.

  3. We propose that DMT1 (show DMRT1 Proteins) deficiency negatively affects metabolism and life span of mature erythrocytes; two other aspects of defective erythropoiesis which contribute to the pathophysiology of the disease

  4. Suggest role for divalent cation transporter DMT1 (show DMRT1 Proteins) in the entry of Hg(II) into the intestinal epithelium.

  5. Six months after RYGB surgery, patients exhibit an increase in DMT1 (show DMRT1 Proteins) expression in the enterocytes of the tips of the villi at the proximal jejunum

  6. In Parkinson's disease, increased iron levels are associated with increased Ndfip1 (show NDFIP1 Proteins) expression for the regulation of DMT1 (show DMRT1 Proteins), including abnormal Ndfip1 (show NDFIP1 Proteins) activation in non-neuronal cell types such as astrocytes.

  7. The DMT1 (show DMRT1 Proteins) IVS4 C(+) allele occurred more frequently in WND (show ATP7B Proteins) than in the healthy controls.

  8. DMT1 (show DMRT1 Proteins) not only exports iron from endosomes, but also serves to import the metal into the mitochondria

  9. Manganese (Mn) transport carriers DMT1 (show DMRT1 Proteins) and FPN1 (show SLC40A1 Proteins) mediate the apical uptake and basolateral exit of Mn in colonic epithelial Caco-2 cells.

  10. DMT1 (show DMRT1 Proteins) is likely involved in endosomal iron transport in placental STB and placental DMT1 (show DMRT1 Proteins) + IRE expression was primarily regulated by the IRE/IRP (show WNT2 Proteins) mechanism

Mouse (Murine) Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 2 (SLC11A2) interaction partners

  1. PrP(C (show PRNP Proteins)) promotes, and possibly regulates, the uptake of iron through DMT1 and Zip14 (show SLC39A14 Proteins) via its ferrireductase activity.

  2. This study reveals a critical function for DMT1 in intestinal nonheme-iron absorption for normal growth and development, and that it is not required for the transport of copper, manganese, or zinc.

  3. We propose that DMT1 deficiency negatively affects metabolism and life span of mature erythrocytes; two other aspects of defective erythropoiesis which contribute to the pathophysiology of the disease

  4. Misregulation of DMT1 is implicated in Parkinson's disease.

  5. Suggest role for divalent cation transporter DMT1 in the entry of Hg(II) into the intestinal epithelium.

  6. The Cu uptake in HEK293 cells that over-expressed the 2/-IRE isoform of DMT1 transporter supports our earlier contention that DMT1 transports Cu as Cu(1+).

  7. Hepatocyte divalent metal-ion transporter-1 is dispensable for hepatic iron accumulation and non-transferrin (show Tf Proteins)-bound iron uptake in mice.

  8. DMT-1 expression in hypothalamic subregions is cre recombinase (show RAG1 Proteins) sensitive, and that central-peripheral pathways may impact beta cell function in the Dmt1 null mouse.

  9. CD61 (show ITGB3 Proteins) regulates the expression of Slc11a2, which is involved in iron transportation in epithelial tissues.

  10. that 1B/(-)IRE DMT1 expression and intracellular iron influx are early downstream responses to NF-kappaB (show NFKB1 Proteins)/RelA (show NFkBP65 Proteins) activation and acetylation during brain ischemia and contribute to the pathogenesis of stroke-induced neuronal damage

Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 2 (SLC11A2) Protein Profile

Protein Summary

This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SLC11A2

  • solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (SLC11A2)
  • metal transporter NRAMP2 (NRAMP2)
  • manganese transport protein (NRAMP2)
  • NRAMP2 (ARALYDRAFT_891495)
  • solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 (slc11a2)
  • solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (slc11a2)
  • solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 (Slc11a2)
  • solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 (SLC11A2)
  • solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (Slc11a2)
  • ATNRAMP2 protein
  • cb426 protein
  • DCT1 protein
  • Dmt1 protein
  • F8G22.4 protein
  • F8G22_4 protein
  • fa07b10 protein
  • MGC138014 protein
  • mk protein
  • Nramp2 protein
  • NRAMP metal ion transporter 2 protein
  • SLC11A2 protein
  • van protein
  • wu:fa07b10 protein
  • zgc:136699 protein

Protein level used designations for SLC11A2

divalent metal transporter 1 , natural resistance-associated macrophage protein 2 , manganese transport protein , NRAMP2 , solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 , cdy , chardonnay , nramp , DMT-1 , NRAMP 2 , Solute carrier family 11 member 2 (natural resistance-associated macrophage protein 2) , divalent cation transporter 1 , microcytic anemia, viable anaemia

GENE ID SPECIES
733595 Sus scrofa
751817 Gallus gallus
841127 Arabidopsis thaliana
5726598 Chlamydomonas reinhardtii
9327403 Arabidopsis lyrata subsp. lyrata
100144712 Xenopus (Silurana) tropicalis
451897 Pan troglodytes
486543 Canis lupus familiaris
512464 Bos taurus
678623 Danio rerio
693986 Macaca mulatta
25715 Rattus norvegicus
4891 Homo sapiens
18174 Mus musculus
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