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facilitates sodium dependent transport of Krebs cycle intermediates including citrate, succinate, alpha-ketoglutarate, and oxaloacetate. Additionally we are shipping Solute Carrier Family 13 Member 2 Antibodies (29) and Solute Carrier Family 13 Member 2 Proteins (6) and many more products for this protein.
Mapping Functionally Important Residues in the Na(+)/Dicarboxylate Cotransporter, NaDC1.
NaDC1 is present throughout the entire proximal tubule, but was not detected in kidney tumors.
cyclophilin (show PPIA ELISA Kits) isoform B is likely responsible for down-regulation of carrier expression by CsA (show ERCC8 ELISA Kits) and that it does so via its chaperone activity on NaDC1 (by direct interaction) rather than its rotamase (show FKBP1B ELISA Kits) activity.
study concludes most of the naturally occurring nonsynonymous SNPs affect protein processing of NaDC1; several also affect functional properties; mutations are predicted to decrease transport activity
This paper describes the cloning and functional characterization of the human Na(+)-coupled citrate transporter (NaCT).
Data show that the sodium-dependent dicarboxylate co-transporter protein (show HNRNPU ELISA Kits) 1 is located in renal proximal tubule lumenal membranes, and that the C-terminal sequence is required for delivery and targeting and may contain the signal sequence.
The Ser (show SIGLEC1 ELISA Kits) or Thr (show TRH ELISA Kits) at position 509 is the most important determinant of functional differences in apparent affinity for substrate and cations. The cation and substrate binding sites are located in close proximity to one another.
Data show that NaDC1 F336C had increased transport activity due to an increased Vmax for succinate.
Slc26a6 (show SLC26A6 ELISA Kits)-null mice exhibit increased renal and intestinal sodium-dependent succinate uptake, as well as urinary hyperoxaluria and hypocitraturia, but no change in urinary pH, indicating enhanced transport activity of NaDC-1.
The acid-activated pathway mediating stimulation of kidney NaDC-1 activity requires a functional ET(B (show EDNRB ELISA Kits)) receptor in vivo and in vitro.
Substrate-dependent inward currents, measured using two-electrode voltage clamp, were similar for glutarate & succinate in Xenopus oocytes expressing mouse NaDC1. Currents evoked by glutarate in rabbit NaDC1 were about 5% of succinate-dependent currents.
Sodium dicarboxylate cotransporter is involved in regulating levels of various Krebs cycle intermediates in the kidney, although impaired uptake of these intermediates does not significantly affect renal function under normal or ischemic stress.
facilitates sodium dependent transport of Krebs cycle intermediates including citrate, succinate, alpha-ketoglutarate, and oxaloacetate
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
, gall-bladder mucin
, Na(+)-coupled citrate transporter
, Na(+)/dicarboxylate cotransporter 1
, renal sodium/dicarboxylate cotransporter
, solute carrier family 13 member 2
, solute carrier family 13, member 2
, sodium/dicarboxylate cotransporter
, sodium/dicarboxylate co-transporter
, intestinal sodium/dicarboxylate cotransporter
, sodium-dependent dicarboxylate transporter