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SLC2A10 encodes a member of the class III facilitative glucose transporter family. Additionally we are shipping SLC2A10 Proteins (3) and many more products for this protein.
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Human Polyclonal SLC2A10 Primary Antibody for WB - ABIN2773837
Segade, Allred, Bowden: Functional characterization of the promoter of the human glucose transporter 10 gene. in Biochimica et biophysica acta 2005
Loss of GLUT10 is associated with impaired cardiovascular system and the notochord and TGFbeta (show TGFB1 Antibodies) signaling
In later embryonic stages, slc2a10 mRNA was detected in the otic vesicles, hatching gland cells, pectoral fin, posterior tectum and swim bladder.
GLUT10 (show SLC2A11 Antibodies) is a dehydroascorbic acid (DAA) transporter and DAA transport is diminished in the endomembranes of fibroblasts from Arterial Tortuosity syndrome patients.
GLUT10 (show SLC2A11 Antibodies) deficiency leads to oxidative stress and non-canonical alphavbeta3 integrin-mediated TGFbeta (show TGFB1 Antibodies) signalling associated with extracellular matrix disarray in arterial tortuosity syndrome skin fibroblasts
100 ATS (show COL4a5 Antibodies) patients have been described, and 21 causal mutations have been identified in the SLC2A10 gene. Study expanded the allelic repertoire of SLC2A10 by identifying two novel mutations.
Two SNPs replicated: the paternal rs2471083-C allele (located near the imprinted KCNK9 (show KCNK9 Antibodies) gene) and the paternal rs3091869-T allele (located near the SLC2A10 gene) increased BMI equally (beta = 0.11 (SD), P<0.0027)
Data show that homozygous and compound heterozygous changes found in PLOD1 and SLC2A10 may confer autosomal recessive effects, and three MYH11 (show MYH11 Antibodies), ACTA2 (show ACTA2 Antibodies) and COL3A1 (show COL3A1 Antibodies) heterozygous variants were considered as putative pathogenic gene alterations.
Our data demonstrate that genetic polymorphism of the SLC2A10 gene is an independent risk factor for PAD in type 2 diabetes.
variation in the coding region of SLC2A10 does not contribute substantially to the pathogenesis of type 2 diabetes
The SLC2A10 gene encodes a glucose transporter and is located on chromosome 20q13, where evidence has been found for linkage to type 2 diabetes (T2D) in multiple studies.
Complex regulatory mechanism of SLC2A10 expression through interaction of multiple transcription factors on basal promotor and prescence of distal repressor sequence suggests fine modulation of GLUT10 (show SLC2A11 Antibodies) levels critical for glucose homeostasis.
GLUT10 (show SLC2A11 Antibodies) deficiency is associated with upregulation of the TGFbeta (show TGFB1 Antibodies) pathway in the arterial wall, a finding also observed in Loeys-Dietz syndrome, in which aortic aneurysms associate with arterial tortuosity
GLUT10 protects cells from oxidative injury.
report that two mouse models, homozygous respectively for G128E and S150F missense substitutions in glut10 do not present any of the vascular, anatomical, or immunohistological abnormalities as encountered in human Arterial tortuosity syndrome patients.
This gene encodes a member of the class III facilitative glucose transporter family. The encoded protein plays a role in regulation of glucose homeostasis. Mutations in this gene have been associated with arterial tortuosity syndrome.
solute carrier family 2 (facilitated glucose transporter), member 10
, facilitative glucose transporter variant 1
, solute carrier family 2, facilitated glucose transporter member 10
, solute carrier family 2 member 10
, solute carrier family 2, facilitated glucose transporter member 10-like
, glucose transporter type 10