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Glucose transporter 2 isoform is an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. Additionally we are shipping Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 2 Antibodies (152) and Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 2 Kits (40) and many more products for this protein.
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Glut2 has an essential role during brain development by facilitating the uptake and availability of glucose and support the involvement of glut2 in brain glucose sensing.
The structure and function of GLUT2 has been remarkably well conserved during vertebrate evolution and open the way for the use of zebrafish as a model species in which to study the biology and pathophysiology of GLUT2.
Single nucleotide polymorphism in SLC2A2 gene is associated with glycemic response to metformin in Type 2 diabetes.
no significant associations between GLUT2 and/or TAS1R2 (show TAS1R2 Proteins) polymorphisms and fillings were found, but allele frequencies of the TAS1R2 (show TAS1R2 Proteins) variant were marginally significantly different between children with DMFT = 0 and DMFT >/=1. no significant interaction between both genes and risk of dental caries was found. GLUT2 and TASR1 (show SRSF10 Proteins) polymorphisms may influence the risk of caries in the Czech population
Homozygous splice-site mutation IVS8+5G>C (c.1068+5 G>C) of SLC2A2 was found in patient A and homozygous nonsense mutation c.1194T>A (p.Tyr398X) in patient B. Patient C harboured a missense mutation c.380C>A (p.Ala127Asp)
Data identified the last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC (show ATIC Proteins))and the putative tyrosine phosphatase PTPLAD1 (show PTPLAD1 Proteins) as new regulators of Glut2(SLC2A2)translocation in HEK293 cells. SiRNA-mediated knockdown of ATIC (show ATIC Proteins) delayed insulin (show INS Proteins) response of Glut2 translocation while depletion of PTPLAD1(HACD3 (show PTPLAD1 Proteins)} strongly enhanced it in HEK293 cells.
A novel 6 nucleotide deletion in GLUT2 gene, a member of the facilitative glucose transporter family, is shown to be segregated with Fanconi-Bickel syndrome in an Iranian family.
SGLT1 (show SLC5A1 Proteins) or GLUT2 interact with the cytoskeleton in the intestinal epithelium during hexose absorption.
Mutations in the GLUT2 gene is associated with ccute metabolic acidosis in Fanconi-Bickel syndrome.
GLUT-2 expression may be associated with cholangiocarcinogenesis of large bile duct and is a helpful marker for detecting high-grade biliary intraepithelial neoplasia lesions in atypical bile ducts.
SGLT1 (show SLC5A1 Proteins) mRNA and GLUT2 mRNA expression are reduced significantly in CACo-2 cells exposed to berry extracts.
the first gain of function mutations for hGLUT2, revealing the importance of its receptor versus transporter function in pancreatic beta cell development and insulin (show INS Proteins) secretion.
the effects of Transmissible gastroenteritis virus infection on glucose uptake and SGLT1 (show SLC5A1 Proteins) and GLUT2 expression, are reported.
analysis of time- and breed-specific expression patterns of GLUT2 and GLUT4 (show SLC2A4 Proteins), which highlight their potential as candidate genes for assessing adipose deposition and muscle development in pigs
The coding regions of GHSR (show GHSR Proteins) and SLC2A2 were sequenced in 12 animals with extreme phenotypes for feed intake and gain; Sixteen SNPs were identified in SLC2A2, and three were detected in GHSR (show GHSR Proteins).
the first intracellular loop of GLUT4 (show SLC2A4 Proteins) contains the retention motif WLGRK, in which W105 plays a prominent role.
hypothalamic arcuate nucleus (Arc (show NOL3 Proteins))POMC (show POMC Proteins)-deficient mice, which develop severe obesity and insulin (show INS Proteins) resistance, unexpectedly exhibit improved glucose tolerance and remain protected from hyperglycemia via decreased renal GLUT2 expression and glycosuria.
analysis of the different diabetic responses to STZ in two different animal strains, which both have similar initial GLUT2 expressions in beta cells
The study demonstrates a previously unrecognized mechanism that controls insulin (show INS Proteins) expression through c-Abl (show ABL1 Proteins)-regulated NKx2.2 (show Nkx2-2 Proteins) and GLUT2.
role of SGLT1 (show SLC5A1 Proteins) and GLUT2 in intestinal glucose transport and sensing
GLUT2-dependent control of parasympathetic activity defines a nervous system/endocrine pancreas axis that is critical for beta cell mass establishment.
Embryonic stem cells isolated in physiological-glucose media retain a functional Glut2 transporter that is expressed by embryos.
in SAMP8 mice, treatment decreased the expression of glucagon (show GCG Proteins), GLUT2, somatostatin (show SST Proteins) and insulin (show INS Proteins) mRNA.
Dysglycosylation of GLUT2 is associated with its re-distribution to lipid-raft microdomain in pancreatic beta cells.
Intestinal dehydroascorbic acid (DHA) transport is mediated by the facilitative sugar transporters, GLUT2 and GLUT8 (show SLC2A8 Proteins)
Glucose transporter 2 isoform is an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. It mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor.
solute carrier family 2, facilitated glucose transporter member 2
, solute carrier family 2 (facilitated glucose transporter), member 2
, glucose transporter 2
, solute carrier family 2, facilitated glucose transporter member 2-like
, glucose transporter type 2, liver
, liver-type glucose transporter
, facilitative glucose transporter