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The protein encoded by SLC30A8 is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. Additionally we are shipping Solute Carrier Family 30 (Zinc Transporter), Member 8 Kits (7) and Solute Carrier Family 30 (Zinc Transporter), Member 8 Proteins (6) and many more products for this protein.
Showing 10 out of 44 products:
Human Polyclonal SLC30A8 Primary Antibody for ELISA, WB - ABIN1535487
Chimienti, Devergnas, Favier, Seve: Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules. in Diabetes 2004
Show all 2 references for ABIN1535487
slc30A8 colocalizes with ghrelin (show GHRL Antibodies) and motilin (show MLN Antibodies) in the gastrointestinal tract of pigs
The absence of ZnT8 in glucagon (show GCG Antibodies)-producing cells in pig islets indicates that zinc homeostasis is mediated by a different cellular mechanism compared with human islet cells.
Our findings demonstrate that glucose homeostasis in the mouse improves as beta-cell ZnT8 activity increases, and remarkably, these changes track Zn(2+) rather than insulin (show INS Antibodies) release in vitro.
Deletion of ZnT8 in a limited subset ( approximately 15%) of alpha-pancreatic cells is sufficient to increase glucagon (show GCG Antibodies) secretion at low glucose concentrations in vitro and in vivo and to improve the response to hypoglycemia.
ischemic retinopathy maybe mediated by aberrant Zn(++) homeostasis caused by ZnT8 downregulation, whereas YC-1 (show RBMS1 Antibodies) plays a neuroprotective role against ischemic insult
Data suggest that, despite a marked reduction in islet zinc content, the absence of ZnT-8 does not have a substantial impact on mouse physiology.
Beta-cell Znt8 alone does not considerably aggravate weight gain and glucose intolerance during metabolic stress imposed by an high-fat high-calorie diet. Global loss of Znt8 is involved in diet-induced obesity and resulting insulin (show INS Antibodies) resistance.
Downregulation of ZnT8 may be associated with impaired function of beta-cells in diabetes.
Mutation of two Pdx-1 (show PDX1 Antibodies)-binding sites in enhancer A markedly reduces fusion gene expression suggesting that this factor contributes to Slc30a8 expression in beta-c
Our data indicate that while, under the conditions studied, ZnT8 is absolutely essential for proper beta cell function, it is largely dispensable for alpha cell function.
Results suggest that an acute decrease in ZnT8 levels impairs beta-cell function and Zn homeostasis, and may contribute to inflammatory cytokine-induced alterations in beta-cell function.
Diabetes-linked zinc transporter ZnT8 is a homodimeric protein expressed by distinct rodent endocrine cell types in the pancreas and other glands.
allele was also associated with increased sway velocity (15%, P = .033; adjusted for age and sex) and reduced SLC30A10 expression
Detection of ZnT8 antibodies in blood precedes detection of classical islet antibodies in children at risk of developing diabetes mellitus type 1.
Studies indicate that people who have particular mutations in a gene called SLC30A8 (Solute carrier (show SERTAD2 Antibodies) family 30, member 8) are 65% less likely to get diabetes.
Association between SLC30A8 rs13266634 Polymorphism and Type 2 Diabetes Risk
Size and the direction of the effect of SLC30A8 risk alleles in man.
We describe early disease manifestations (including videos) in 5 previously unreported Indian children, carrying novel homozygous SLC30A10 mutation
Zinc supplementation appears to affect the early insulin (show INS Antibodies) response to glucose differentially by rs13266634 genotype and could be beneficial for diabetes prevention and/or treatment for some individuals based on SLC30A8 variation.
Data indicate that the SLC30A8 polymorphisms are associated with type 2 diabetes in the Saudi population but not for FTO (show FTO Antibodies), MC4R (show MC4R Antibodies) and KCNQ1 (show KCNQ1 Antibodies) gene variants.
genotypes of the polymorphic markers of KCNJ11 (show KCNJ11 Antibodies), SLC30A8 and CDKN2B (show CDKN2B Antibodies) genes showed the presence of association with T2DM in Russian population, while for the FTO (show FTO Antibodies) gene was not found statistically significant associations with type 2 diabetes
Suggest rs3019885 SLC30A8 SNP is not a susceptibility factor for abdominal aortic aneurysms in an Italian population.
This gene is highly expressed in the liver and is inducible by manganese. Its protein product appears to be critical in maintaining manganese levels, and has higher specificity for manganese than zinc. Loss of function mutations appear to result in a pleomorphic phenotype, including dystonia and adult-onset parkinsonism. Alternatively spliced transcript variants have been observed for this gene.
, solute carrier family 30 (zinc transporter), member 8
, zinc transporter 8
, solute carrier family 30 member 8
, solute carrier family 30 (zinc transporter), member 3
, zinc transporter 8-like
, solute carrier family 39 (zinc transporter), member 8
, zinc transporter ZIP8
, zinc transporter ZnT-8
, zinc transporter 10