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Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 7 Proteins (SLC4A7)

This locus encodes a sodium bicarbonate cotransporter. Additionally we are shipping SLC4A7 Antibodies (44) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC4A7 9497 Q9Y6M7
SLC4A7 218756  
Rat SLC4A7 SLC4A7 117955 Q9R1N3
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Top SLC4A7 Proteins at antibodies-online.com

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days
$12,906.52
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 69 to 74 Days
$9,050.32
Details

SLC4A7 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine) ,
,

More Proteins for Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 7 (SLC4A7) Interaction Partners

Human Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 7 (SLC4A7) interaction partners

  1. Upregulation of NBCn1 during human breast carcinogenesis contributes to the characteristic acid distribution within human breast carcinomas.

  2. A meta-analysis of genome-wide association studies of blood pressure and hypertension in Chinese identified three new loci (CACNA1D (show CACNA1D Proteins), CYP21A2 (show CYP21A2 Proteins), and MED13L) and a newly discovered variant near SLC4A7.

  3. We demonstrate, for the first time, that 3 different pHi regulators responsible for acid extruding, i.e. NHE and NBC (show SLC4A4 Proteins), and MCT (show MCAT Proteins), are functionally co-existed in cultured radial artery smooth muscle cells.

  4. The SLC4A7 variant rs4973768 is associated with breast cancer risk.

  5. Simultaneous switching of the putative transmembrane segment (TM6) and TM12 of NBCe1 (show SLC4A4 Proteins) for those from NBCn1 severely impairs the expression of the transporter at the plasma membrane.

  6. Data show that DeltaNErbB2 expression elicited Na(+), HCO(3)(-) cotransporter NBCn1 upregulation, Ser (show SIGLEC1 Proteins)(703)-phosphorylation of Na(+)/H(+) exchanger NHE1 (show SLC9A1 Proteins).

  7. The present study generated a series of chimeras of human NBCe1 (show SLC4A4 Proteins)-A and human NBCn1-A (SLC4A7). Replacing the fourth extracellular loop (EL4) of human NBCe1 (show SLC4A4 Proteins)-A with EL4 of NBCn1-A creates an electroneutral NBC (show SLC4A4 Proteins).

  8. NBCn1 inhibition attenuated cathepsin release and had no net effect on viability of MCF7 cells.

  9. The cystic fibrosis transmembrane conductance regulator (show CFTR Proteins) interacts with and regulates the activity of the bicarbonate salvage trransporter isoform 3

  10. NBC3 and CAII (show CA2 Proteins) interact to maximize the HCO(3)(-) transport rate. Although PKA decreased NBC3 transport activity, it did so independently of the NBC3/CAII (show CA2 Proteins) interaction and did not involve phosphorylation of NBC3Ct.

Mouse (Murine) Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 7 (SLC4A7) interaction partners

  1. NBCn1 facilitates acid extrusion from breast cancer tissue, maintains the alkaline intracellular environment and promotes aggressive cancer development and growth

  2. The electroneutral Na+-HCO3- cotransporter (show SLC4A4 Proteins) NBCn1 plays an essential role in murine duodenal acid-base balance and colonic mucus layer build-up in vivo

  3. Slc4a7 is a major regulator of basal and FSK-stimulated duodenal HCO3 secretion

  4. Intracellular acidification of vascular smooth muscle and endothelial cells after knockout of NBCn1 inhibits nitric oxide-mediates signaling in isolated arteries and perturbs blood pressure regulation.

  5. Damage of the sensory epithelia at the high frequency zone of the cochlea suggests that NBC3 may play an important physiological role in this region.

  6. NBCn1 mediates the Na+-dependent bicarbonate transport important for pH(i) regulation in smooth muscle cells of mouse mesenteric, coronary, and cerebral small arteries.

  7. most cases, hypoxia reduced NBCn1 levels by 20-50%, and NCBE (show SLC4A10 Proteins) levels by 15-40% in cerebral cortex, subcortex, cerebellum, and hippocampus, both after 14 and 28 days, and in both pups and adults.

  8. We conclude that NBCn1 has a broad expression profile, supporting previous findings based on immunoreactivity, and suggest several new tissues where NBCn1 may be important.

SLC4A7 Protein Profile

Protein Summary

This locus encodes a sodium bicarbonate cotransporter. The encoded transmembrane protein appears to transport sodium and bicarbonate ions in a 1:1 ratio, and is thus considered an electroneutral cotransporter. The encoded protein likely plays a critical role in regulation of intracellular pH involved in visual and auditory sensory transmission. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Gene names and symbols associated with SLC4A7

  • solute carrier family 4, sodium bicarbonate cotransporter, member 7 (SLC4A7)
  • solute carrier family 4, sodium bicarbonate cotransporter, member 7 (slc4a7)
  • solute carrier family 4, sodium bicarbonate cotransporter, member 7 (Slc4a7)
  • E430014N10Rik protein
  • MGC83246 protein
  • NBC2 protein
  • NBC3 protein
  • NBCn1 protein
  • NBCn1-G protein
  • SBC2 protein
  • SLC4A6 protein
  • SLC4A7 protein

Protein level used designations for SLC4A7

solute carrier family 4, sodium bicarbonate cotransporter, member 7 , sodium bicarbonate cotransporter 3 , sodium bicarbonate cotransporter 3-like , bicarbonate transporter , sodium bicarbonate cotransporter 2 , sodium bicarbonate cotransporter 2b , solute carrier family 4 member 7 , Na-bicarbonate cotransporter , NBC-like protein , electroneutral sodium bicarbonate cotransporter 1

GENE ID SPECIES
420658 Gallus gallus
431976 Xenopus laevis
460236 Pan troglodytes
485637 Canis lupus familiaris
510209 Bos taurus
100051260 Equus caballus
100380158 Xenopus (Silurana) tropicalis
100399880 Callithrix jacchus
100469067 Ailuropoda melanoleuca
100546095 Meleagris gallopavo
100600640 Nomascus leucogenys
9497 Homo sapiens
218756 Mus musculus
117955 Rattus norvegicus
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