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Receptor for somatostatin with higher affinity for somatostatin-14 than -28. Additionally we are shipping SSTR1 Antibodies (114) and SSTR1 Kits (20) and many more products for this protein.
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Human SSTR1 Primary Antibody for AP, Func - ABIN1330528
Breitkopf, Lo, Leung, Wang, Yu, Carr, Zloty, Cowan, Shapiro, McElwee: Somatostatin expression in human hair follicles and its potential role in immune privilege. in The Journal of investigative dermatology 2013
Data showed that the distribution of somatostatin (show SST Proteins) receptor (SSTR (show SSTR3 Proteins)) subtypes among the 199 pancreatic neuroendocrine tumors (PNETs) was: SSTR2 (show SSTR2 Proteins) (54.8%), SSTR1 (53.3%), SSTR4 (51.8%), SSTR5 (show SSTR5 Proteins) (33.7%), and SSTR3 (show SSTR3 Proteins) (28.6%).
An immunohistochemical investigation of the expression of somatostatin (show SST Proteins) receptor subtypes
Aberrant methylation inactivates somatostatin (show SST Proteins) and SSTR1 in head and neck squamous cell carcinoma.
The UMB-7 may prove of great value in the identification of sst1-expressing tumors during routine histopathological examinations. This may open up new routes for diagnostic and therapeutic intervention.
SSTR (show SSTR3 Proteins)-PET showed high sensitivity for imaging bone, soft tissue and brain metastases, and particularly in combination with CT had a significant impact on clinical stage and patient management.
Activated/phosphorylated pMAPK 44/42 was detected in 82% of medulloblastomas, all subtypes, and in 62.5% of primitive neuroectodermal tumors with coexpression of SSR1 (show SSR1 Proteins) in one third.
Somatostatin (show SST Proteins) receptor imaging (SRI (show SRI Proteins)) using SPECT or PET as a whole-body imaging technique has become a crucial part of the management of Neuroendocrine tumors
Tumor cells in the tissue samples of the patients diagnosed with advanced-stage hepatocellular carcinoma expressed a high proportion of SSTR1 and SSTR5 (show SSTR5 Proteins).
Somatostatin receptor 1 is a novel methylated gene driven by EBV infection in gastric cancer cells and acts as a potential tumour suppressor.
Data demonstrate that cells transfected with SSTR1 or SSTR1/5 negatively regulates EGF (show EGF Proteins) mediated effects attributed to the inhibition of EGFR (show EGFR Proteins) phosphorylation.
This study showed that reduced expression of the Sstr1 which modulate antidepressant action in hippocampus.
The expression and localization of the three receptors (SSTR3 (show SSTR3 Proteins)-SSTR5 (show SSTR5 Proteins)) in wild-type (WT), single-knockout (SSTR1 KO) and double-knockout SSTR1/SSTR2 (show SSTR2 Proteins) (DKO) mice, are reported.
SSTR1 was expressed in Kolliker's organ on E14, on cochlear duct hair cells & supporting cells on E17 and only on the organ of Corti at birth, increasing & peaking at P14 (show PCOLCE Proteins) but dropping off at P21.
SSTR1-like immunoreactivity increases in hypothalamus except in paraventricular nucleus of ApoD (show APOD Proteins)(-/-) mice.
SST (show SST Proteins) and SSTRs might play an important role in regulation of neurodegeneration
Data suggest an important role for the brain somatostatin receptor 1 subtype in the modulation of the gastrointestinal response to activation of brain CRF (show CRH Proteins) pathways.
The effect of sst2 (show SSTR2 Proteins) receptor knockout on sst1 receptor mRNA localization and binding sites throughout the brain has been determined.
The localization of somatostatin (show SST Proteins) to retinal amacrine cells, together with the expression of somatostatin (show SST Proteins) receptors in amacrine, bipolar and horizontal cells suggests that somatostatin (show SST Proteins) acts at multiple levels of retinal circuitry.
Brain somatostatin (show SST Proteins) receptors 1,2,4 and 5 are up-regulated in somatostatin (show SST Proteins)-deficient mice, and SSTR3 (show SSTR3 Proteins) is down-regulated.
sst1 receptor loss causes a significant increase in retinal levels of somatostatin-14 (show SST Proteins) (SRIF (show SST Proteins)) whereas it does not affect SRIF (show SST Proteins) messenger RNA, indicating that sst1 receptors play a role in limiting retinal SRIF (show SST Proteins) at the post-transcriptional level.
5-HT(1A (show HTR1A Proteins)), SST (show SST Proteins)(1), and SST (show SST Proteins)(2) receptors mediate nonadrenergic IPSPs in the noncholinergic (VIP (show Vip Proteins)) secretomotor neurons of the submucous plexus of the guinea pig ileum.
Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.
somatostatin receptor type 1
, somatostatin receptor 1
, Somatostatin receptor subtype 1