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Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. Additionally we are shipping Somatostatin Receptor 3 Antibodies (13) and Somatostatin Receptor 3 Kits (1) and many more products for this protein.
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Data showed that the distribution of somatostatin (show SST Proteins) receptor (SSTR) subtypes among the 199 pancreatic neuroendocrine tumors (PNETs) was: SSTR2 (show SSTR2 Proteins) (54.8%), SSTR1 (show SSTR1 Proteins) (53.3%), SSTR4 (51.8%), SSTR5 (show SSTR5 Proteins) (33.7%), and SSTR3 (28.6%).
Data indicate that somatostatin (show SST Proteins) receptor scintigraphy (SRS (show SMS Proteins)) and immunohistochemical results for somatostatin (show SST Proteins) and dopamine receptors sstr2 (show SSTR2 Proteins), sstr3, sstr5 (show SSTR5 Proteins) and D2R (show DRD2 Proteins) were compared in neuroendocrine neoplasms tissues.
findings provide new insights in understanding the antiproliferative role of SSTR3 in breast tumor biology.
An immunohistochemical investigation of the expression of somatostatin (show SST Proteins) receptor subtypes
In conclusions, in CNFAs, high expression of somatostatin (show SST Proteins) receptors is much less common than that of D2R (show DRD2 Proteins)
SSTR2A and SSTR3 are more likely to be expressed in SDH-deficient pheochromocytomas/paragangliomas compared with tumors demonstrating normal SDHB (show SDHB Proteins) staining pattern.
constitutive SSTR3 activity mediates transcriptional repression of GH.
High SSTR3 expression is associated with gallbladder cancer.
Determination of the expression of SSTR3 in an attempt to establish correlations and/or associations with clinical characteristics of patients with nonfunctioning pituitary adenomas.
mRNA levels of SSTR2a, SSTR3 and SSTR5 (show SSTR5 Proteins) in neuroendocrine lung cancer affected patients, were determined
results implicate beta-arrestin in the modulation of Sstr3 ciliary localization and further suggest a role for beta-arrestin in the mediation of Sstr3 ciliary signaling.
The expression and localization of the three receptors (SSTR3-SSTR5 (show SSTR5 Proteins)) in wild-type (WT), single-knockout (SSTR1 (show SSTR1 Proteins) KO) and double-knockout SSTR1 (show SSTR1 Proteins)/SSTR2 (show SSTR2 Proteins) (DKO) mice, are reported.
Both Sstr3 (and SStr2 (show SSTR2 Proteins)) receptors are required for the anticonvulsant effects mediated by cortistatin-14 (show CORT Proteins).
SSTR3 immunoreactivity increases in ApoD (show APOD Proteins)(-/-) mice in all major nuclei of hypothalamus, median eminence, and ependymal cells of third ventricle.
Mchr1 (show MCHR1 Proteins) and Sstr3 are expressed and colocalized within cilia in multiple mouse brain regions, and they form heteromers.
this novel finding that Rab21 (show RAB21 Proteins) regulates SSTR3 trafficking suggests that Rab21 (show RAB21 Proteins) may play a role in trafficking of other GPCRs.
somatostatin receptor 3 expression was restricted to the plasma membrane of cilia in insulin- and growth hormone-secreting cells of the mouse, differing from previously reported immunohistochemical localization in cell bodies
Receptor coupling to adenylyl cyclase is disrupted upon Sstr3 C-tail deletions.
From the data of this study shown that somatostatin receptor 3 is critical for object recognition memory.
The effect of sst2 receptor knockout on sst3 receptor mRNA localization and binding sites throughout the brain has been determined.
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR3 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in brain and pancreatic islets. SSTR3 is functionally coupled to adenylyl cyclase.
somatostatin receptor type 3
, somatostatin receptor 3
, somatostatin receptor 28
, somatostatin receptor subtype 3