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Sorbin and SH3 Domain Containing 2 Proteins (Sorbs2)

Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. Additionally we are shipping Sorbs2 Antibodies (24) and Sorbs2 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Sorbs2 8470 O94875
Sorbs2 234214  
Rat Sorbs2 Sorbs2 114901 O35413
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Top Sorbs2 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$2,355.83
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

Sorbs2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

Mouse (Murine)

More Proteins for Sorbin and SH3 Domain Containing 2 (Sorbs2) Interaction Partners

Human Sorbin and SH3 Domain Containing 2 (Sorbs2) interaction partners

  1. SORBS2 transcription is activated by telomere position effect-over long distance upon telomere shortening in muscle cells from patients with facioscapulohumeral dystrophy

  2. ArgBP2 inhibits proliferation, migration, and invasion of gastric cancer cells.MORC2 down-regulates the ArgBP2 via histone methylation in gastric cancer cells.

  3. This study confirmed that SORBS2 as genetic modifiers of age at onset of Alzheimer disease.

  4. ArgBP2 interaction with alpha-actinin and actin stress fibers inhibits cell migration

  5. Tyrosine phosphorylation of ARGBP2 interferes with a SH3 mediated self-interaction, thereby controlling its panel of interacting partners and related functions.

  6. SORBS2 and TLR3 (show TLR3 Proteins) induce premature senescence in primary human fibroblasts and keratinocytes.

  7. Sarcoplasmic sorbin and SH3 domain-containing protein 2 is released from damaged cardiac tissue into the bloodstream upon lethal acute myocardial infarction.

  8. In epithelial NMuMG cells, immunofluorescence analyses revealed localization of ArgBP2 at tight junctions and mutation analyses found a second SH3 domain to be important for ArgBP2 localization to the cell-cell contact sites.

  9. A co-localization of SORBS2 and eEF1A (show EEF1A1 Proteins) was evidenced at level of plasma membrane, thus suggesting the involvement of eEF1A1 (show EEF1A1 Proteins) in novel key signal transduction complexes.

  10. Reconstitution of SORBS2 expression resulted significant reduction in cell proliferation, colony formation and anchorage-independent growth in CaSki, HPKII and HaCaT cells, whereby anchorage-independent growth could only be investigated for CaSki cells

Mouse (Murine) Sorbin and SH3 Domain Containing 2 (Sorbs2) interaction partners

  1. The study screened CrkL (show CRKL Proteins) binding proteins using RNA interference (RNAi) and identified Sorbs1 (show SORBS1 Proteins) and Sorbs2 as two proteins that are enriched at AChR clusters and are required for the formation of AChR aggregation in vitro.

Sorbs2 Protein Profile

Protein Summary

Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with Sorbs2

  • sorbin and SH3 domain containing 2 (sorbs2)
  • sorbin and SH3 domain containing 2 (SORBS2)
  • sorbin and SH3 domain containing 2 (LOC100231821)
  • sorbin and SH3 domain containing 2 (Sorbs2)
  • 2010203O03Rik protein
  • 9430041O17RIK protein
  • A530071H08 protein
  • Argbp2 protein
  • DKFZp468F1119 protein
  • mKIAA0777 protein
  • PRO0618 protein

Protein level used designations for Sorbs2

sorbin and SH3 domain containing 2 , sorbin and SH3 domain-containing protein 2 , sorbin and SH3 domain-containing protein 2-like , Arg binding protein 2 , Arg/Abl-interacting protein 2 , Arg/Abl-interacting protein ArgBP2 , arg/Abl-interacting protein 2 , nArgBP2 , neural ArgBP2 , Sorbin and SH3 domain-containing protein 2 , sorbin polypeptide

GENE ID SPECIES
100196922 Xenopus (Silurana) tropicalis
461640 Pan troglodytes
696139 Macaca mulatta
100014403 Monodelphis domestica
100050682 Equus caballus
100153277 Sus scrofa
100172173 Pongo abelii
100231821 Taeniopygia guttata
100344295 Oryctolagus cuniculus
100413518 Callithrix jacchus
100469106 Ailuropoda melanoleuca
8470 Homo sapiens
234214 Mus musculus
114901 Rattus norvegicus
396719 Sus scrofa
482906 Canis lupus familiaris
614391 Bos taurus
100724374 Cavia porcellus
422719 Gallus gallus
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