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Sorting Nexin 27 Proteins (SNX27)

SNX27 encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. Additionally we are shipping SNX27 Antibodies (55) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SNX27 81609 Q96L92
SNX27 76742 Q3UHD6
SNX27 260323 Q8K4V4
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Top SNX27 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,540.17
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

SNX27 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Sorting Nexin 27 (SNX27) Interaction Partners

Human Sorting Nexin 27 (SNX27) interaction partners

  1. SNX27 inhibits the Wnt regulated transcription activity of TCF/LEF. Our results suggested that SNX27 interacts with Frizzled receptors to regulate the endocytosis and stability of Fzds

  2. SNX27 interaction with FAM21 is required for the precise localization of SNX27 at an endosomal subdomain.

  3. SNX27 deficiency is now added to the growing list of neurodegenerative disorders associated with retromer dysfunction.

  4. The results suggest that SNX27 undergoes dynamic partitioning between different membrane domains during immunological synapse assembly, and underscore the contribution of unique lipid interactions for SNX27 orchestration of cargo trafficking.

  5. The double knockdown of SNX17 (show SNX17 Proteins) and SNX27 results in a striking reduction of papillomavirus 16 infection due to interruption of their binding to the L2 viral protein.

  6. RNAi-mediated suppression of ANKRD50 phenocopies loss of SNX27-retromer function.

  7. a function of SNX27 in regulating beta-amyloid (Abeta (show APP Proteins)) generation by modulating gamma-secretase activity.

  8. VPS26A binding increases the affinity of the SNX27 PDZ domain for PDZ- binding motifs by an order of magnitude, revealing cooperativity in cargo selection.

  9. Ras-association domain of sorting Nexin 27 is critical for regulating expression of GIRK potassium channels.

  10. Direct interaction of the SNX27 PDZ domain with the retromer subunit VPS26 (show VPS26A Proteins) is necessary and sufficient to prevent lysosomal entry of SNX27 cargo.

Mouse (Murine) Sorting Nexin 27 (SNX27) interaction partners

  1. a function of SNX27 in regulating beta-amyloid (Abeta (show APP Proteins)) generation by modulating gamma-secretase activity.

  2. VPS26A binding increases the affinity of the SNX27 PDZ domain for PDZ- binding motifs by an order of magnitude, revealing cooperativity in cargo selection.

  3. SNX27-dependent mechanism of inhibitory plasticity in DA neurons is a potential intervention point for disorders of dopamine neurons.

  4. SNX27 associates with ZO-2 (show TJP2 Proteins) and modulates the epithelial tight junction.

  5. a model by which SNX27 regulates trafficking of beta-Pix (show ARHGEF7 Proteins) to focal adhesions and thereby influences cell motility.

  6. indicate that SNX27 may function to regulate endocytosis and/or endosomal sorting of NR2C (show GRIN2C Proteins)

  7. SNX27 and NHERF (show SLC9A3R1 Proteins) specifically interact with the 5-HT4a receptor splice variant

  8. These data support a previously unreported role for diacylglycerol kinase zeta (show DGKZ Proteins) in the modulation of membrane trafficking, which may also help to define SNX27 function.

  9. This study shows that SNX27 promotes the endosomal movement of Kir3 (or GIRK) channels, leading to reduced surface expression, increased degradation and smaller Kir3 potassium currents.

SNX27 Protein Profile

Protein Summary

This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mouse is responsible for the specific recruitment of an isoform of serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein.

Gene names and symbols associated with Sorting Nexin 27 Proteins (SNX27)

  • sorting nexin family member 27 (SNX27)
  • sorting nexin family member 27 (Snx27)
  • 5730552M22Rik protein
  • ESTM45 protein
  • ESTM47 protein
  • mKIAA0488 protein
  • Mrt1 protein
  • MY014 protein
  • R75405 protein

Protein level used designations for Sorting Nexin 27 Proteins (SNX27)

methamphetamine-responsive transcript 1 , sorting nexin-27 , MAP-responsive gene protein , PDZ protein Mrt1 , PDZ-protein Mrt1 , methamphetamine (MAP) responsive transcript 1 , methamphetamine-responsive transcript 1 protein

GENE ID SPECIES
81609 Homo sapiens
76742 Mus musculus
260323 Rattus norvegicus
513214 Bos taurus
425666 Gallus gallus
483200 Canis lupus familiaris
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