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SNX27 encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. Additionally we are shipping SNX27 Antibodies (55) and many more products for this protein.
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SNX27 interaction with FAM21 is required for the precise localization of SNX27 at an endosomal subdomain.
SNX27 deficiency is now added to the growing list of neurodegenerative disorders associated with retromer dysfunction.
The results suggest that SNX27 undergoes dynamic partitioning between different membrane domains during immunological synapse assembly, and underscore the contribution of unique lipid interactions for SNX27 orchestration of cargo trafficking.
The double knockdown of SNX17 (show SNX17 Proteins) and SNX27 results in a striking reduction of papillomavirus 16 infection due to interruption of their binding to the L2 viral protein.
RNAi-mediated suppression of ANKRD50 phenocopies loss of SNX27-retromer function.
a function of SNX27 in regulating beta-amyloid (Abeta (show APP Proteins)) generation by modulating gamma-secretase activity.
VPS26A binding increases the affinity of the SNX27 PDZ domain for PDZ- binding motifs by an order of magnitude, revealing cooperativity in cargo selection.
Ras-association domain of sorting Nexin 27 is critical for regulating expression of GIRK potassium channels.
Direct interaction of the SNX27 PDZ domain with the retromer subunit VPS26 (show VPS26A Proteins) is necessary and sufficient to prevent lysosomal entry of SNX27 cargo.
SNX27 interacts with MRP4 near the plasma membrane and promotes endocytosis of MRP4 and thereby negatively regulates its cell surface expression and transport function.
SNX27-dependent mechanism of inhibitory plasticity in DA neurons is a potential intervention point for disorders of dopamine neurons.
SNX27 associates with ZO-2 (show TJP2 Proteins) and modulates the epithelial tight junction.
a model by which SNX27 regulates trafficking of beta-Pix (show ARHGEF7 Proteins) to focal adhesions and thereby influences cell motility.
indicate that SNX27 may function to regulate endocytosis and/or endosomal sorting of NR2C (show GRIN2C Proteins)
SNX27 and NHERF (show SLC9A3R1 Proteins) specifically interact with the 5-HT4a receptor splice variant
These data support a previously unreported role for diacylglycerol kinase zeta (show DGKZ Proteins) in the modulation of membrane trafficking, which may also help to define SNX27 function.
This study shows that SNX27 promotes the endosomal movement of Kir3 (or GIRK) channels, leading to reduced surface expression, increased degradation and smaller Kir3 potassium currents.
This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mouse is responsible for the specific recruitment of an isoform of serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein.
methamphetamine-responsive transcript 1
, sorting nexin-27
, MAP-responsive gene protein
, PDZ protein Mrt1
, PDZ-protein Mrt1
, methamphetamine (MAP) responsive transcript 1
, methamphetamine-responsive transcript 1 protein