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Binds to GC boxes promoters elements. Additionally we are shipping Sp5 Transcription Factor Antibodies (8) and many more products for this protein.
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sp5 transcription factors mediate the downstream responses to Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling in several developmental processes in zebrafish.
human Sp5 is a member of Sp transcription factor family with a role in human cancers
Functional studies revealed that knockdown of Nanog eliminated the mESC self-renewal-promoting ability of Sp5. Finally, we demonstrated that the self-renewal-promoting function of Sp5 was largely dependent on its zinc finger domains
Sp5 is able to convert mouse epiblast stem cells into a naive pluripotent state.
Sp5/8 bind directly to GC boxes in Wnt (show WNT2 Proteins) target gene enhancers and to adjacent, or distally positioned, chromatin-bound T-cell factor (Tcf) 1 (show HNF1A Proteins)/lymphoid enhancer factor (Lef) 1 (show LEF1 Proteins) to facilitate recruitment of beta-catenin (show CTNNB1 Proteins) to target gene enhancers.
Sp5 and Sp8 (show SP8 Proteins) are pivotal downstream effectors of Wnt3a (show WNT3A Proteins)/beta-catenin (show CTNNB1 Proteins) that are essential for the self-renewal and differentiation of neuromesodermal stem cells.
Sp5 transcription factor mediates the downstream responses to Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling by directly repressing Sp1 (show SP1 Proteins) target genes
Binds to GC boxes promoters elements. Probable transcriptional activator that has a role in the coordination of changes in transcription required to generate pattern in the developing embryo (By similarity).
transcription factor Sp5
, trans-acting transcription factor 5
, Sp5 transcription factor