Sp7 Transcription Factor Proteins (SP7)

SP7 encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Additionally we are shipping SP7 Antibodies (37) and SP7 Kits (24) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SP7 121340 Q8TDD2
Rat SP7 SP7 300260  
SP7 170574 Q8VI67
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Top SP7 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
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HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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SP7 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Sp7 Transcription Factor (SP7) Interaction Partners

Zebrafish Sp7 Transcription Factor (SP7) interaction partners

  1. Sp7 plays a critical role in limiting the level of signaling and the rate of bone growth

  2. FGF and Wnt (show WNT2 Proteins)/beta-Catenin (show CTNNB1 Proteins) pathways act in part by directing transcription of osx to promote osteoblast differentiation at sites of bone formation.

  3. Data show the endogenous sp7 gene expression in the otic placode and vesicle, and in forming skeletal structures in Tg(sp7:EGFP)b1212 line.

Human Sp7 Transcription Factor (SP7) interaction partners

  1. SP7 gene promoter is robustly enriched in epigenetic repressive marks that may explain its poor transcriptional response to osteoblast differentiating media in umbilical cord derived mesenchymal stem cells.

  2. Eight and five of the nine samples were negative for cell adhesion molecule 1 (show CADM1 Proteins) and Osterix respectively. The other markers showed no statistical significance(CD151 (show CD151 Proteins),ALP (show ALP Proteins)). osteoblastic differentiation can occur in carcinoma cells and that cell adhesion molecule 1 (show CADM1 Proteins) could be a useful marker for identifying this phenomenon in carcinoma tissues

  3. The results suggest that Osterix plays an important role in increasing BMP- 4 (show BMP4 Proteins)-induced Cx43 (show GJA1 Proteins) activity.

  4. The expression of specific targets Smad1 (show GARS Proteins) and Osterix was significantly increased in the presence of Pi and restored by coincubation with Mg(2 (show MUC7 Proteins)+). As miR (show MLXIP Proteins)-30b, miR (show MLXIP Proteins)-133a, and miR (show MLXIP Proteins)-143 are negatively regulated by Pi and restored by Mg(2 (show MUC7 Proteins)+) with a congruent modulation of their known targets Runx2 (show RUNX2 Proteins), Smad1 (show GARS Proteins), and Osterix, our results provide a potential mechanistic explanation of the observed upregulation of these master switches of o

  5. Preameloblast-Derived Factors Mediate Osteoblast Differentiation of Human Bone Marrow Mesenchymal Stem Cells by Runx2 (show RUNX2 Proteins)-Osterix-BSP (show KLK6 Proteins) Signaling.

  6. Osx (show MID1 Proteins) might function as a potential regulator for the proliferation and odontoblastic differentiation of hDPCs.

  7. Data suggest that beta-catenin (beta-cat) signaling upregulates the expression of osterix (OSX) in pre-osteoblastic and bone marrow stromal cells.

  8. The 2 genes RUNX1 (show RUNX1 Proteins) and SP7 resulted differently expressed in cells cultured on metallic supports if compared with the expression recorded for OIC

  9. c-Src (show SRC Proteins) signaling modulates osteoblast differentiation at least in part through phosphorylation of Osterix.

  10. Pin1 (show PIN1 Proteins) regulates the osteogenic activity of Osterix.

Mouse (Murine) Sp7 Transcription Factor (SP7) interaction partners

  1. The data support a model in which Dlx recruitment of Sp7 to osteoblast enhancers underlies Sp7-directed osteoblast specification.

  2. Mmp13 (show MMP13 Proteins) is selectively regulated of by 1,25-Dihydroxyvitamin D3, PTH (show PTH Proteins), and Osterix through distal enhancers.

  3. These results indicated that olfactory bulb development was not significantly impaired in the absence of Osx.

  4. Wnt3a (show WNT3A Proteins) induces Osx expression via p38 MAPK (show MAPK14 Proteins) signaling in dental follicle cells. Wnt3a (show WNT3A Proteins)-induced Osx expression was inhibited in the presence of p38 mitogen-activated protein kinase (show MAPK14 Proteins) (MAPK (show MAPK1 Proteins)) inhibitors (SB203580 and SB202190) at gene and protein levels, as assessed by real-time PCR and immunocytohistochemistry, respectively.

  5. Transfection assay demonstrated that Osx was able to activate Bsp (show KLK6 Proteins) promoter reporter in a dose-dependent manner. To define minimal region of Bsp (show KLK6 Proteins) promoter activated by Osx, a series of deletion mutants of Bsp (show KLK6 Proteins) promoter were generated, and the minimal region was narrowed down to the proximal 100 bp. Point-mutagenesis studies showed that one GC-rich (show RELB Proteins) site was required for Bsp (show KLK6 Proteins) promoter activation by Osx.

  6. OSX served a key role in the development and progression of ALD-induced VSMC calcification. This observation may aid in the explanation of the role of OSX in the pathogenesis of vascular calcification

  7. results suggest that expression of Sp7 during the early stage of Satb2 (show SATB2 Proteins)-induced osteogenic differentiation of BMSCs is regulated by miR (show MLXIP Proteins)-27a.

  8. Fibrillin-2 (show FBN2 Proteins) and periostin (show POSTN Proteins) are target genes in Osterix-mediated osteoblast differentiation.

  9. osterix is a downstream target of IGF1R (show IGF1R Proteins) in chondrocytes.

  10. cells expressing osterix are mesenchymal progenitors contributing to all relevant cell types during morphogenesis.

SP7 Protein Profile

Protein Summary

This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein is a bone specific transcription factor and is required for osteoblast differentiation and bone formation.

Gene names and symbols associated with Sp7 Transcription Factor Proteins (SP7)

  • Sp7 transcription factor (sp7)
  • Sp7 transcription factor (SP7)
  • osterix (LOC404701)
  • Sp7 transcription factor (Sp7)
  • Sp7 transcription factor 7 (Sp7)
  • 6430578P22Rik protein
  • C22 protein
  • OI11 protein
  • OI12 protein
  • osterix protein
  • Osx protein
  • sp7 protein

Protein level used designations for Sp7 Transcription Factor Proteins (SP7)

transcription factor Sp7 , transcription factor osterix , Sp7 transcription factor , osterix , transcription factor Sp7-like , zinc finger protein osterix , trans-acting transcription factor 7

GENE ID SPECIES
405789 Danio rerio
467004 Pan troglodytes
607857 Canis lupus familiaris
702575 Macaca mulatta
100063836 Equus caballus
100101324 Xenopus laevis
100189548 Xenopus (Silurana) tropicalis
100407102 Callithrix jacchus
100587177 Nomascus leucogenys
404701 Sus scrofa
121340 Homo sapiens
531995 Bos taurus
300260 Rattus norvegicus
170574 Mus musculus
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