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SP7 encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Additionally we are shipping SP7 Antibodies (37) and SP7 Kits (16) and many more products for this protein.
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FGF and Wnt (show WNT2 Proteins)/beta-Catenin (show CTNNB1 Proteins) pathways act in part by directing transcription of osx to promote osteoblast differentiation at sites of bone formation.
Data show the endogenous sp7 gene expression in the otic placode and vesicle, and in forming skeletal structures in Tg(sp7:EGFP)b1212 line.
The expression of specific targets Smad1 (show GARS Proteins) and Osterix was significantly increased in the presence of Pi and restored by coincubation with Mg(2 (show MUC7 Proteins)+). As miR (show MLXIP Proteins)-30b, miR (show MLXIP Proteins)-133a, and miR (show MLXIP Proteins)-143 are negatively regulated by Pi and restored by Mg(2 (show MUC7 Proteins)+) with a congruent modulation of their known targets Runx2 (show RUNX2 Proteins), Smad1 (show GARS Proteins), and Osterix, our results provide a potential mechanistic explanation of the observed upregulation of these master switches of o
Preameloblast-Derived Factors Mediate Osteoblast Differentiation of Human Bone Marrow Mesenchymal Stem Cells by Runx2 (show RUNX2 Proteins)-Osterix-BSP (show KLK6 Proteins) Signaling.
Osx (show MID1 Proteins) might function as a potential regulator for the proliferation and odontoblastic differentiation of hDPCs.
Data suggest that beta-catenin (beta-cat) signaling upregulates the expression of osterix (OSX) in pre-osteoblastic and bone marrow stromal cells.
The 2 genes RUNX1 (show RUNX1 Proteins) and SP7 resulted differently expressed in cells cultured on metallic supports if compared with the expression recorded for OIC
c-Src (show SRC Proteins) signaling modulates osteoblast differentiation at least in part through phosphorylation of Osterix.
Pin1 (show PIN1 Proteins) regulates the osteogenic activity of Osterix.
Runx2 (show RUNX2 Proteins)-Sp7 molecular complex functionally cooperate for maximal induction of cell-phenotype-restricted genes
Osterix is a novel target of protein kinase A, and protein kinase A modulates osteoblast differentiation partially through the regulation of Osterix.
results provide a molecular description of a mechanism for Osx (show MID1 Proteins) and Runx2 (show RUNX2 Proteins) transcriptional cooperation that is subject to further regulation by MAPK (show MAPK1 Proteins)-activating signals during osteogenesis.
OSX served a key role in the development and progression of ALD-induced VSMC calcification. This observation may aid in the explanation of the role of OSX in the pathogenesis of vascular calcification
results suggest that expression of Sp7 during the early stage of Satb2 (show SATB2 Proteins)-induced osteogenic differentiation of BMSCs is regulated by miR (show MLXIP Proteins)-27a.
Fibrillin-2 (show FBN2 Proteins) and periostin (show POSTN Proteins) are target genes in Osterix-mediated osteoblast differentiation.
osterix is a downstream target of IGF1R (show IGF1R Proteins) in chondrocytes.
cells expressing osterix are mesenchymal progenitors contributing to all relevant cell types during morphogenesis.
Results propose that Utx (show KDM6A Proteins) plays important roles in osteoblast differentiation by controlling the expressions of Runx2 (show RUNX2 Proteins) and Osterix.
Decreased expression of Osterix, as well as impaired TGFbeta and BMP2 signaling, contribute to the observed osteopenic bone phenotype of TIEG1 KO mice.
Intermittent stretching promotes osteogenic differentiation of bone marrow derived mesenchymal stem cells; the p38MAPK (show MAPK14 Proteins)-osterix pathway has an important role in the control of osteogenesis related gene expression.
CHIP targets Osx for ubiquitination and degradation in osteoblasts after chronic exposure to TNF-alpha (show TNF Proteins).
This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein is a bone specific transcription factor and is required for osteoblast differentiation and bone formation.
transcription factor Sp7
, transcription factor osterix
, Sp7 transcription factor
, transcription factor Sp7-like
, zinc finger protein osterix
, trans-acting transcription factor 7