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Spectrin Repeat Containing, Nuclear Envelope 2 Proteins (SYNE2)

The protein encoded by SYNE2 is a nuclear outer membrane protein that binds cytoplasmic F-actin. Additionally we are shipping SYNE2 Antibodies (12) and SYNE2 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat SYNE2 SYNE2 299151  
Mouse SYNE2 SYNE2 319565 Q6ZWQ0
SYNE2 23224 Q8WXH0
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Top SYNE2 Proteins at antibodies-online.com

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

SYNE2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

More Proteins for Spectrin Repeat Containing, Nuclear Envelope 2 (SYNE2) Interaction Partners

Mouse (Murine) Spectrin Repeat Containing, Nuclear Envelope 2 (SYNE2) interaction partners

  1. SYNE2 is important for normal retinal development. We have determined that not only is photoreceptor nuclear migration affected, but also the positions of Muller glia and secondary neurons are disturbed early in retinal development

  2. nesprin-dependent recruitment of kinesin-1 to the nuclear envelope through the interaction of a conserved LEWD motif with kinesin light chain might be a general mechanism for cell-type-specific nuclear positioning during development.

  3. Loss of Nesprin 1 or 2, or both, led to impairment of gene expression changes in response to biomechanical stimuli. These data suggest a model whereby biomechanical signals are communicated from proteins of the outer nuclear membrane

  4. ectopic expression of BRAP2 (show BRAP Proteins) inhibits nuclear localization of HMG20A (show HMG20A Proteins) and NuMA1, and prevents nuclear envelope accumulation of SYNE2

  5. Data indicate roles for linkers of nucleus to cytoskeleton (LINC) molecules nesprin2giant and nesprin3, which anchor actin cap fibers to the nucleus.

  6. functions for Nesprin-2 at the nuclear envelope (NE) in gene regulation and in regulation of the actin cytoskeleton which impact on wound healing

  7. Syne-2, SUN1 (show SUN1 Proteins) and SUN2 (show SUN2 Proteins) play critical roles during interkinetic nuclear migration and photoreceptor cell migration in the mouse retina development.

  8. The p104 (show RB1 Proteins) protein interacts with p85alpha and is involved in the regulation of p27(Kip1 (show CDKN1B Proteins)) expression for the reduction of cellular proliferation.

  9. The Nesprin-2 the conserved C-terminal amino acids PPPX is essential for the interaction with a C-terminal region in Sun1 (show SUN1 Proteins).

  10. SUN1 (show SUN1 Proteins) interacts with nuclear lamin A (show LMNA Proteins) and cytoplasmic nesprins (nesprin-1 and nesprin-2)to provide a physical connection between the nuclear lamina and the cytoskeleton.

Human Spectrin Repeat Containing, Nuclear Envelope 2 (SYNE2) interaction partners

  1. We show that AMPH-1 (show AMPH Proteins)/BIN1 (show BIN1 Proteins) binds to nesprin and actin, as well as to the microtubule-binding protein CLIP170 in both species. We propose that BIN1 (show BIN1 Proteins) has a direct and evolutionarily conserved role in nuclear positioning, altered in myopathies.

  2. nesprin-1 and nesprin-2 both regulate nuclear and cytoplasmic architecture.

  3. nesprin-dependent recruitment of kinesin-1 to the nuclear envelope through the interaction of a conserved LEWD motif with kinesin light chain might be a general mechanism for cell-type-specific nuclear positioning during development.

  4. Each mutation in LMNA (show LMNA Proteins) has a distinct impact on the Nersprin-2 interaction that substantially explains how distinct mutations in widely expressed genes lead to the formation of phenotypically different diseases.

  5. High Nesprin-2 expression is associated with colorectal cancer.

  6. ectopic expression of BRAP2 (show BRAP Proteins) inhibits nuclear localization of HMG20A (show HMG20A Proteins) and NuMA1, and prevents nuclear envelope accumulation of SYNE2.

  7. Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds.

  8. Study presents crystal structures of the human SUN2-KASH1/2 complex, i.e. SUN2 complexed with the C-terminal 29 residues of human Nesprin-1 or -2 (the core of the LINC complex).

  9. novel isoform, nesprin-2-epsilon, was found to be the major mRNA and protein product of the nesprin-2 gene.

  10. Nesprin-2 interacts with {alpha}-catenin (show CTNNA1 Proteins) and regulates Wnt (show WNT2 Proteins) signaling at the nuclear envelope.

SYNE2 Protein Profile

Protein Summary

The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SYNE2

  • spectrin repeat containing, nuclear envelope 2 (Syne2)
  • spectrin repeat containing, nuclear envelope 2 (SYNE2)
  • spectrin repeat containing, nuclear envelope 2 (syne2)
  • spectrin repeat containing, nuclear envelope 2 (LOC100227700)
  • spectrin repeat containing, nuclear envelope 2 (LOC100346489)
  • 6820443O06Rik protein
  • AW546258 protein
  • D12Ertd777e protein
  • EDMD5 protein
  • mKIAA1011 protein
  • Nesp2 protein
  • Nesp2g protein
  • Nesprin-2 protein
  • NUA protein
  • NUANCE protein
  • RGD1305248 protein
  • SYNE-2 protein
  • SYNE2 protein
  • TROPH protein

Protein level used designations for SYNE2

spectrin repeat containing, nuclear envelope 2 , synaptic nuclear envelope 2 , nesprin-2-like , nesprin 2 , nesprin-2 , nuance , nuclear envelope spectrin repeat protein 2 , nucleus and actin connecting element protein , synaptic nuclear envelope protein 2 , nuclear envelope spectrin repeat-2 , polytrophin , synaptic nuclei expressed gene 2

GENE ID SPECIES
299151 Rattus norvegicus
423509 Gallus gallus
490729 Canis lupus familiaris
540504 Bos taurus
746581 Pan troglodytes
100061983 Equus caballus
100216251 Xenopus (Silurana) tropicalis
100227700 Taeniopygia guttata
100346489 Oryctolagus cuniculus
100391491 Callithrix jacchus
100554331 Anolis carolinensis
319565 Mus musculus
23224 Homo sapiens
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