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anti-Spectrin alpha 1, Erythrocytic (SPTA1) Antibodies

Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. Additionally we are shipping Spectrin alpha 1, Erythrocytic Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SPTA1 289257  
SPTA1 20739 P08032
SPTA1 6708 P02549
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Top anti-Spectrin alpha 1, Erythrocytic Antibodies at antibodies-online.com

Showing 10 out of 12 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated IHC (fro), IF, IP, WB   0.1 mg Log in to see 6 to 8 Days
$544.50
Details
Human Mouse Un-conjugated WB   0.1 mg Log in to see 6 to 8 Days
$313.50
Details
Human Mouse Un-conjugated IP, IHC, WB Western blotting polypeptides of ghosts of human erythrocytes (Lane 1, total protein profile) and reaction with MAb AF10 (Erythroid a-Spectrin)(Lane 2) and MAb DB2 (Erythroid b-Spectrin) 100 μg Log in to see 9 Days
$352.28
Details
Human Mouse Un-conjugated IHC (fro), IF, ELISA, WB   200 μL Log in to see 8 to 10 Days
$1,688.50
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 2 to 3 Days
$289.00
Details
Chicken Rabbit Un-conjugated IF, WB   200 μL Log in to see 8 to 10 Days
$683.83
Details
Human Mouse Un-conjugated IHC (fro), IP, WB   100 μg Log in to see 8 to 10 Days
$947.83
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB   100 μL Log in to see 14 to 21 Days
$269.50
Details
Human Rabbit Un-conjugated IF   100 μL Log in to see 8 to 10 Days
$551.83
Details
Human Mouse Un-conjugated ICC, IHC (fro), IP, WB   100 μg Log in to see 8 to 10 Days
$507.83
Details

SPTA1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Rat (Rattus)
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Mouse (Murine)
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Human ,
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Top referenced anti-Spectrin alpha 1, Erythrocytic Antibodies

  1. Human Monoclonal SPTA1 Primary Antibody for IHC (fro), IF - ABIN1109120 : Tani, Ylänne, Virtanen: Expression of megakaryocytic and erythroid properties in human leukemic cells. in Experimental hematology 1996 (PubMed)

More Antibodies against Spectrin alpha 1, Erythrocytic Interaction Partners

Mouse (Murine) Spectrin alpha 1, Erythrocytic (SPTA1) interaction partners

  1. a new function for spectrins in the stability of invadosomes and the coupling between actin regulation and ECM (show MMRN1 Antibodies) degradation

  2. Calcium plays a role in regulating the expression and function of beta-adducin to sustain normal organization of the spectrin-based cytoskeleton and the differentiation properties in keratinocytes through the calmodulin/EGFR/cadherin signaling pathway.

  3. organization of a spectrin-like cytoskeleton is associated with keratinocyte differentiation, and cytoskeleton disruption is mediated by either PKCdelta (show PKCd Antibodies)(Thr505) phosphorylation associated with phosphorylated adducin or due to reduction of endogenous adducin

  4. Results of this study provide evidence for a role for spectrin in different steps of megakaryocyte development through its participation in the formation of invaginated membranes and in the maintenance of proplatelet structure.

  5. Analysis of 3 new alleles reveals previously unknown consequences of red blood cell (RBC (show CACNA1C Antibodies)) spectrin deficiency, resulting in markedly reduced RBC (show CACNA1C Antibodies) membrane spectrin content, decreased band 3 (show SLC4A1 Antibodies), and absent beta-adducin (show ADD2 Antibodies).

  6. Murine recessive hereditary spherocytosis, sph/sph (show NUMA1 Antibodies), is caused by a mutation in the erythroid alpha-spectrin gene.

Human Spectrin alpha 1, Erythrocytic (SPTA1) interaction partners

  1. The authors show that SUB1-mediated processing of MSP1 is important for parasite viability, the processing modifies the secondary structure of MSP1 and activates its capacity to bind spectrin.

  2. The authors demonstrate that the initial vacuolar membrane around internalized Babesia divergens is formed from protein and lipid components of the red blood cells plasma membrane, including band 3, glycophorin A and spectrin.

  3. a new function for spectrins in the stability of invadosomes and the coupling between actin regulation and ECM (show MMRN1 Antibodies) degradation

  4. Case Report: severe hemolytic jaundice and a phenotype of hereditary spherocytosis due alpha-spectrin (show SPTAN1 Antibodies) mutations.

  5. In this review, we summarize the state of knowledge about interactions between spectrin and membrane lipids

  6. A novel exon 2 alpha spectrin (show SPTAN1 Antibodies) mutation is identified in two families of European ancestry with hereditary pyropoikilocytosis.

  7. The heterozygous c.121C>T mutation of SPTA1 gene induces an amino acid change p.Arg41Trp in the alpha1 domain of the alpha-spectrin (show SPTAN1 Antibodies) protein.

  8. Data show that transcription cofactor TAF3 (show TAF3 Antibodies) is required for transcription of the alpha spectrin (show SPTAN1 Antibodies) SPTA1 gene.

  9. The common hereditary elliptocytosis-associated alpha-spectrin leucine260proline mutation perturbs erythrocyte membranes by stabilizing spectrin in the closed dimer conformation.

  10. The unusually slow, two-state kinetics of spectrin assembly in solution, was investigated.

Spectrin alpha 1, Erythrocytic (SPTA1) Antigen Profile

Protein Summary

Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia.

Gene names and symbols associated with SPTA1

  • spectrin, alpha, erythrocytic 1 (elliptocytosis 2) (Spta1) antibody
  • spectrin alpha, erythrocytic 1 (Spta1) antibody
  • spectrin, alpha, erythrocytic 1 (elliptocytosis 2) (SPTA1) antibody
  • AF093576 antibody
  • AI451697 antibody
  • EL2 antibody
  • ha antibody
  • HPP antibody
  • HS3 antibody
  • ihj antibody
  • nmf4 antibody
  • sph antibody
  • SPH3 antibody
  • Spna-1 antibody
  • Spna1 antibody
  • SPTA antibody

Protein level used designations for SPTA1

erythroid spectrin alpha , spectrin alpha chain, erythrocyte , alpha-spectrin 1, erythroid , erythroid alpha-spectrin , hemolytic anemia , neuroscience mutagenesis facility, 4 , spectrin alpha 1 , spectrin alpha chain, erythrocytic 1 , spherocytosis , alpha-I spectrin

GENE ID SPECIES
289257 Rattus norvegicus
20739 Mus musculus
6708 Homo sapiens
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