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Sphingomyelin phosphodiesterase 1, Acid Lysosomal Proteins (SMPD1)

The protein encoded by SMPD1 is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. Additionally we are shipping Sphingomyelin phosphodiesterase 1, Acid Lysosomal Antibodies (71) and Sphingomyelin phosphodiesterase 1, Acid Lysosomal Kits (34) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SMPD1 6609 P17405
SMPD1 20597 Q04519
Rat SMPD1 SMPD1 308909  
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Top Sphingomyelin phosphodiesterase 1, Acid Lysosomal Proteins at antibodies-online.com

Showing 9 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human His tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$704.00
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HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast REACT_Tick His tag   1 mg Log in to see 56 to 66 Days
$2,942.50
Details
HOST_Baculovirus infected Insect Cells Mouse His tag 20 μg Log in to see 16 Days
$382.80
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 19 Days
$785.40
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$889.07
Details

SMPD1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,

Top referenced Sphingomyelin phosphodiesterase 1, Acid Lysosomal Proteins

  1. Human SMPD1 Protein expressed in Baculovirus infected Insect Cells - ABIN2003951 : Lansmann, Schuette, Bartelsen, Hoernschemeyer, Linke, Weisgerber, Sandhoff: Human acid sphingomyelinase. in European journal of biochemistry / FEBS 2003 (PubMed)

More Proteins for Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) Interaction Partners

Cow (Bovine) Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) interaction partners

  1. results provide evidence that translocated lysosomal V1 H(+)-ATPase (show ATP6AP1 Proteins) contributes to formation of local acid microenvironment to facilitate activation of ASM and consequent membrane raft(MR) aggregation, forming MR redox signalosomes and mediating redox signaling in coronary endothelial cells

  2. Acid sphingomyelinase activation serves as a triggering mechanism, leading to fusion of membrane proximal lysosomes into lipid rafts clusters on the cell membrane of coronary arterial endothelial cells.

  3. Report lysosomal targeting and trafficking of acid sphingomyelinase to lipid raft platforms in coronary endothelial cells.

Human Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) interaction partners

  1. A comprehensive updated review of already reported and newly identified SMPD1 variants of Niemann-Pick Types A and B disease has been presented. (Review)

  2. a conserved haplotype and shared 280 Kb region around the SMPD1 gene was observed in the patients analyzed, indicating that the variant originated from a common ancestor

  3. ASM activation may be involved in the pathophysiology of Kawasaki disease

  4. These results indicate that increased EGR1 (show EGR1 Proteins)/3 and ASMase expression play an important role in cellular ceramide increase by RSV treatment.

  5. The results of this study suggested that disruptive mutations in SMPD1 constitute a risk factor for parkindon disease.

  6. This is the first evidence that supports the possibility that sphingolipid metabolism is affected via the induction of ASMase by the Nrf2 (show GABPA Proteins) pathway.

  7. ASM has a pivotal role in adaptive immune T-cell responses.

  8. Patterns of alternatively spliced SMPD1 transcripts are significantly different in patients with systemic inflammatory response syndrome and severe sepsis/septic shock compared to control subjects allowing discrimination of respective disease entity.

  9. The mechanisms by which pyocyanin induces the release of mitochondrial ROS (show ROS1 Proteins) and by which ROS (show ROS1 Proteins) induce neutrophil death via mitochondrial acid sphingomyelinase was identified.

  10. Results show four novel mutations in SMPD1 in Iranian patients with type A or B Niemann-Pick disease extending the genotypic spectrum of the disease.

Mouse (Murine) Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) interaction partners

  1. Inhibition of the smpd1 by antidepressants prevents stress-induced phosphorylation/activation of p38K indicating that antidepressants indirectly target p38K via the acid sphingomyelinase/ceramide system.

  2. The reduction of membrane sphingomyelin (SM)is due to transcriptional upregulation of neutral sphingomyelinase (show SMPD2 Proteins) (NSM) through active RhoA (show RHOA Proteins).

  3. Intravenous injection of B16F10 melanoma cells into wild-type mice resulted in multiple lung metastases, while Asm-deficient mice (Smpd1(-/-) mice) were protected from pulmonary tumor spread.

  4. Acid sphingomyelinase deficiency reduces S. aureus-induced lung edema.

  5. Ceramide production in M-CSF (show CSF1R Proteins)-deprived macrophages arises from a combination of ASMase activity and de novo synthesis.

  6. aSMase-deficient mouse is the first example in which microglial lipid inclusions are directly related to a loss of retinal function

  7. ASMase deficiency determined resistance to hepatic steatosis mediated by a high fat diet.

  8. results provide the mechanism for dysferlin-mediated repair of skeletal muscle sarcolemma and identify ASM as a potential therapy for dysferlinopathy

  9. Acid sphingomyelinase (ASM) controls autophagy maturation in smooth muscle cells. ASM maintains smooth muscle cell homeostasis and its contractile phenotype. ASM plays a protective role in smooth muscle dysfunction and atherosclerosis.

  10. The action of A-SMase is mediated by the activation of the extracellular signal-regulated kinase, the subsequent proteasomal degradation of the Microphtalmia-associated transcription factor (Mitf (show MITF Proteins)).

Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) Protein Profile

Protein Summary

The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with SMPD1

  • sphingomyelin phosphodiesterase (AaeL_AAEL003402)
  • acid sphingomyelinase (ASM)
  • acid sphingomyelinase (AFUA_4G06640)
  • sphingomyelin phosphodiesterase 1, acid lysosomal (SMPD1)
  • sphingomyelin phosphodiesterase 1 (SMPD1)
  • sphingomyelin phosphodiesterase 1, acid lysosomal (Smpd1)
  • A-SMase protein
  • Afu4g06640 protein
  • ASM protein
  • aSMase protein
  • NPD protein
  • SMPD1 protein
  • Zn-SMase protein

Protein level used designations for SMPD1

sphingomyelin phosphodiesterase , acid sphingomyelinase , sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) , sphingomyelin phosphodiesterase 1, acid lysosomal , sphingomyelin phosphodiesterase 1 , sphingomyelin phosphodiesterase-like , aSMase

GENE ID SPECIES
5578088 Aedes aegypti
280724 Bos taurus
3509254 Aspergillus fumigatus Af293
450990 Pan troglodytes
711248 Macaca mulatta
100030863 Monodelphis domestica
100172518 Pongo abelii
100307047 Ovis aries
100353898 Oryctolagus cuniculus
100400920 Callithrix jacchus
6609 Homo sapiens
485334 Canis lupus familiaris
505097 Bos taurus
20597 Mus musculus
308909 Rattus norvegicus
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