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anti-Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) Antibodies

The protein encoded by SMPD1 is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. Additionally we are shipping Sphingomyelin phosphodiesterase 1, Acid Lysosomal Kits (31) and Sphingomyelin phosphodiesterase 1, Acid Lysosomal Proteins (12) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SMPD1 6609 P17405
SMPD1 20597 Q04519
SMPD1 308909  
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Top anti-Sphingomyelin phosphodiesterase 1, Acid Lysosomal Antibodies at antibodies-online.com

Showing 10 out of 70 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB SMPD1 Antibody (C-term) (ABIN656161) immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Cow Rabbit Un-conjugated WB   100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB Western blot analysis of Acid Sphingomyelinase expression in A431 (A), HepG2 (B), SP2/0 (C), H9C2 (D) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Bat Rabbit Un-conjugated IHC (p), WB Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 7 to 9 Days
$676.50
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Immunohistochemistry-Paraffin: SMPD1 Antibody [NBP2-20426] - Immunohistochemical analysis of paraffin-embedded Breast ca, using antibody at 1:500 dilution. Western Blot: SMPD1 Antibody [NBP2-20426] - Sample (30 ug of whole cell lysate) A: Raji 10% SDS PAGE gel, diluted at 1:1000. 0.1 mL Log in to see 8 to 11 Days
$447.56
Details
Human Rabbit Un-conjugated ICC, IHC, IP, WB 100 μg Log in to see 9 to 11 Days
$365.20
Details
Human Mouse Un-conjugated IHC, WB Immunohistochemistry: SMPD1 Antibody (3H7) [NBP2-45889] - Analysis of Carcinoma of Human thyroid tissue. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min) Immunohistochemistry: SMPD1 Antibody (3H7) [NBP2-45889] - Analysis of Human Kidney tissue. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min) 0.1 mL Log in to see 8 to 11 Days
$447.56
Details
Human Rabbit Un-conjugated WB SMPD1 antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 2 to 3 Days
$473.93
Details

SMPD1 Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-Sphingomyelin phosphodiesterase 1, Acid Lysosomal Antibodies

  1. Cow (Bovine) Polyclonal SMPD1 Primary Antibody for WB - ABIN2776371 : Zeidan, Jenkins, Hannun: Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway. in The Journal of cell biology 2008 (PubMed)

  2. Human Polyclonal SMPD1 Primary Antibody for FACS, IHC (p) - ABIN656161 : Ullio, Casas, Brunk, Sala, Fabriàs, Ghidoni, Bonelli, Baccino, Autelli: Sphingosine mediates TNF?-induced lysosomal membrane permeabilization and ensuing programmed cell death in hepatoma cells. in Journal of lipid research 2012 (PubMed)

More Antibodies against Sphingomyelin phosphodiesterase 1, Acid Lysosomal Interaction Partners

Cow (Bovine) Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) interaction partners

  1. results provide evidence that translocated lysosomal V1 H(+)-ATPase (show ATP6AP1 Antibodies) contributes to formation of local acid microenvironment to facilitate activation of ASM and consequent membrane raft(MR) aggregation, forming MR redox signalosomes and mediating redox signaling in coronary endothelial cells

  2. Acid sphingomyelinase activation serves as a triggering mechanism, leading to fusion of membrane proximal lysosomes into lipid rafts clusters on the cell membrane of coronary arterial endothelial cells.

  3. Report lysosomal targeting and trafficking of acid sphingomyelinase to lipid raft platforms in coronary endothelial cells.

Human Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) interaction partners

  1. the p.Ala359Asp mutation causes structural alterations in the hydrophobic environment where ASM is located, decreasing its enzymatic activity

  2. Airway cells with lower SMPD1 activity increases neutrophil chemotaxis towards them.

  3. The results identify acid sphingomyelinase as a novel target of Lycium Chinense berries to decrease saturated/unsaturated fatty acid sphingomyelin ratio, known to be useful for cell health. Consistent with these data, the berries regulate specifically gene expression to protect cells from apoptosis.

  4. ASMase mediated the 50-Hz MF-induced EGFR (show EGFR Antibodies) clustering via ceramide which was produced from hydrolyzation on lipid rafts

  5. acid sphingomyelinase-1

  6. ASM is a negative regulator of regulatory T Cell development.

  7. We report on an infant with a new frameshift mutation (c.575dupG) of the SMPD1 gene.

  8. Seven novel mutations (c.518-519insT, c.562_563insC, c.792Gdel, c.949G>A, c.1487_1499delACCGTGTGTACCA, c.1495T>C and c.1670T>C) of the SMPD1 gene were identified in four patients. Only one fetus had two mutations of the SMPD1 gene of amniocytes

  9. although ebeta,5alpha,6beta-triol is more specific than 7-KC, it has been found to be significantly elevated in patients with Niemann-Pick type A, a lysosomal storage disorder caused by mutations in the SMPD1 gene

  10. A comprehensive updated review of already reported and newly identified SMPD1 variants of Niemann-Pick Types A and B disease has been presented. (Review)

Mouse (Murine) Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) interaction partners

  1. These findings indicate a novel pathway in tumor metastasis, i.e., tumor cell mediated activation of P-selectin (show SELP Antibodies) in platelets, followed by activation and secretion of Asm and in turn release of ceramide and tumor metastasis. The data suggest that p38 MAPK (show MAPK14 Antibodies) acts downstream from P-selectin (show SELP Antibodies) and is necessary for the secretion of Asm.

  2. Inhibition of ASM in diabetic CACs improved membrane fluidity and homing of these cells to damaged retinal vessels. Collectively, these findings indicate that selective modulation of sphingolipid metabolism in BM-derived cell populations in diabetes normalizes the reparative/proinflammatory cell balance and can be explored as a novel therapeutic strategy for treating diabetic retinopathy.

  3. Inhibition of the smpd1 by antidepressants prevents stress-induced phosphorylation/activation of p38K indicating that antidepressants indirectly target p38K via the acid sphingomyelinase/ceramide system.

  4. The reduction of membrane sphingomyelin (SM)is due to transcriptional upregulation of neutral sphingomyelinase (show SMPD2 Antibodies) (NSM) through active RhoA (show RHOA Antibodies).

  5. Intravenous injection of B16F10 melanoma cells into wild-type mice resulted in multiple lung metastases, while Asm-deficient mice (Smpd1(-/-) mice) were protected from pulmonary tumor spread.

  6. Acid sphingomyelinase deficiency reduces S. aureus-induced lung edema.

  7. Ceramide production in M-CSF (show CSF1R Antibodies)-deprived macrophages arises from a combination of ASMase activity and de novo synthesis.

  8. aSMase-deficient mouse is the first example in which microglial lipid inclusions are directly related to a loss of retinal function

  9. ASMase deficiency determined resistance to hepatic steatosis mediated by a high fat diet.

  10. results provide the mechanism for dysferlin (show DYSF Antibodies)-mediated repair of skeletal muscle sarcolemma and identify ASM as a potential therapy for dysferlinopathy

Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) Antigen Profile

Protein Summary

The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with SMPD1

  • sphingomyelin phosphodiesterase (AaeL_AAEL003402) antibody
  • acid sphingomyelinase (ASM) antibody
  • acid sphingomyelinase (AFUA_4G06640) antibody
  • sphingomyelin phosphodiesterase 1, acid lysosomal (SMPD1) antibody
  • sphingomyelin phosphodiesterase 1 (SMPD1) antibody
  • sphingomyelin phosphodiesterase 1, acid lysosomal (Smpd1) antibody
  • A-SMase antibody
  • Afu4g06640 antibody
  • ASM antibody
  • aSMase antibody
  • NPD antibody
  • SMPD1 antibody
  • Zn-SMase antibody

Protein level used designations for SMPD1

sphingomyelin phosphodiesterase , acid sphingomyelinase , sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) , sphingomyelin phosphodiesterase 1, acid lysosomal , sphingomyelin phosphodiesterase 1 , sphingomyelin phosphodiesterase-like , aSMase

GENE ID SPECIES
5578088 Aedes aegypti
280724 Bos taurus
3509254 Aspergillus fumigatus Af293
450990 Pan troglodytes
711248 Macaca mulatta
100030863 Monodelphis domestica
100172518 Pongo abelii
100307047 Ovis aries
100353898 Oryctolagus cuniculus
100400920 Callithrix jacchus
6609 Homo sapiens
485334 Canis lupus familiaris
505097 Bos taurus
20597 Mus musculus
308909 Rattus norvegicus
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