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The protein encoded by SMPD1 is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. Additionally we are shipping Sphingomyelin phosphodiesterase 1, Acid Lysosomal Kits (34) and Sphingomyelin phosphodiesterase 1, Acid Lysosomal Proteins (12) and many more products for this protein.
Showing 10 out of 72 products:
Human Polyclonal SMPD1 Primary Antibody for FACS, IHC (p) - ABIN656161
Ullio, Casas, Brunk, Sala, Fabriàs, Ghidoni, Bonelli, Baccino, Autelli: Sphingosine mediates TNF?-induced lysosomal membrane permeabilization and ensuing programmed cell death in hepatoma cells. in Journal of lipid research 2012
results provide evidence that translocated lysosomal V1 H(+)-ATPase (show ATP6AP1 Antibodies) contributes to formation of local acid microenvironment to facilitate activation of ASM and consequent membrane raft(MR) aggregation, forming MR redox signalosomes and mediating redox signaling in coronary endothelial cells
Acid sphingomyelinase activation serves as a triggering mechanism, leading to fusion of membrane proximal lysosomes into lipid rafts clusters on the cell membrane of coronary arterial endothelial cells.
Report lysosomal targeting and trafficking of acid sphingomyelinase to lipid raft platforms in coronary endothelial cells.
Enzyme activities (acid alpha-glucosidase (GAA), galactocerebrosidase (GALC (show GALC Antibodies)), glucocerebrosidase (GBA (show GBA Antibodies)), alpha-galactosidase A (GLA (show GLA Antibodies)), alpha-iduronidase (IDUA (show IDUA Antibodies)) and sphingomyeline phosphodiesterase-1 (SMPD-1)) were measured on ~43,000 de-identified dried blood spot (DBS (show MCF2L Antibodies)) punches, and screen positive samples were submitted for DNA sequencing to obtain genotype confirmation of disease risk
This study shows that the ASM alternative splicing pattern could be a biological target with diagnostic relevance and could serve as a novel biomarker for Major depressive disorder
stress-induced activation of p38 MAPK (show MAPK14 Antibodies) and apoptosis in endothelial cells and established the link between the acid sphingomyelinase/ceramide and p38 MAPK (show MAPK14 Antibodies) pathways.
Elevated acid sphingomyelinase (ASM) activity in the lung tumor environment and blood serum of patients with non-small cell lung cancer (NSCLC).
this is the largest study on mutation analysis of patients with ASM-deficient Niemann-Pick disease reported in literature and also the first study on the SMPD1 gene mutation spectrum in India.
ASM and ceramides, together with STX6 (show STX6 Antibodies) and cholesterol, constitute a new regulatory mechanism for the exit of Met from the Golgi during its biosynthetic route.
the p.Ala359Asp mutation causes structural alterations in the hydrophobic environment where ASM is located, decreasing its enzymatic activity
Airway cells with lower SMPD1 activity increases neutrophil chemotaxis towards them.
The results identify acid sphingomyelinase as a novel target of Lycium Chinense berries to decrease saturated/unsaturated fatty acid sphingomyelin ratio, known to be useful for cell health. Consistent with these data, the berries regulate specifically gene expression to protect cells from apoptosis.
ASMase mediated the 50-Hz MF-induced EGFR (show EGFR Antibodies) clustering via ceramide which was produced from hydrolyzation on lipid rafts
The results show that mice lacking acid sphingomyelinase had a significant increase in myelin recovery and a significantly higher oligodendrocyte cell count after 2 weeks remyelination compared to wildtype littermates.
These findings suggest that the paradoxical antidepressant effects of alcohol in depressed organisms are mediated by ASM and its control of sphingolipid homeostasis
this study shows that Asm-deficient mice develop brain measles virus infection that is consistent with an enhanced Treg frequency and/or activity
K8/K18 (show KRT18 Antibodies)-dependent PKCdelta (show PKCd Antibodies)- and ASMase-mediated modulation of lipid raft size can explain the more prominent FasR-mediated signaling resulting from K8/K18 (show KRT18 Antibodies) loss.
Aged platelets elicit lung injury in primed recipient mice, which can be alleviated by pharmacological inhibition or genetic deletion of acid sphingomyelinase.
Transgenic ASM female, but not male, mice showed an impaired social preference and a depressive- and anxiogenic-like phenotype, which could be normalized by amitriptyline treatment.
this study shows decreased T cell numbers in Asm-deficient, burn-injured, and microbiota-depleted mice
These findings indicate a novel pathway in tumor metastasis, i.e., tumor cell mediated activation of P-selectin (show SELP Antibodies) in platelets, followed by activation and secretion of Asm and in turn release of ceramide and tumor metastasis. The data suggest that p38 MAPK (show MAPK14 Antibodies) acts downstream from P-selectin (show SELP Antibodies) and is necessary for the secretion of Asm.
Inhibition of ASM in diabetic CACs improved membrane fluidity and homing of these cells to damaged retinal vessels. Collectively, these findings indicate that selective modulation of sphingolipid metabolism in BM-derived cell populations in diabetes normalizes the reparative/proinflammatory cell balance and can be explored as a novel therapeutic strategy for treating diabetic retinopathy.
Inhibition of the smpd1 by antidepressants prevents stress-induced phosphorylation/activation of p38K indicating that antidepressants indirectly target p38K via the acid sphingomyelinase/ceramide system.
The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified.
, acid sphingomyelinase
, sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase)
, sphingomyelin phosphodiesterase 1, acid lysosomal
, sphingomyelin phosphodiesterase 1
, sphingomyelin phosphodiesterase-like