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anti-Sphingosine Kinase 1 (SPHK1) Antibodies

The protein encoded by SPHK1 catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Additionally we are shipping Sphingosine Kinase 1 Proteins (13) and Sphingosine Kinase 1 Kits (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SPHK1 8877 Q9NYA1
SPHK1 20698 Q8CI15
SPHK1 170897 Q91V26
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Top anti-Sphingosine Kinase 1 Antibodies at antibodies-online.com

Showing 10 out of 173 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated ELISA, WB ABIN308402 (2µg/ml) staining of Human Peripheral Blood Mononucleocyte ... 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Rabbit Un-conjugated EIA, WB The anti-SphK1 Pab is used in Western blot (Lane 2) to detect c-myc-ta... Western blot analysis of anti-hSPHK1-M1 Pab in 293 cell line lysates t... 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Formalin-fixed and paraffin-embedded human cancer tissue (hepatocarcin... The anti-SPHK1 Pab is used in Western blot to detect SPHK1 in mouse ki... 0.4 mL Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated WB The anti-SphK1 Pab (ABIN391345) is used in Western blot (Lane 2) to de... Western blot analysis of anti-hSPHK1-M1 Pab (ABIN391345) in 293 cell l... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB The anti-SPHK1 Pab (ABIN391346) is used in Western blot to detect SPHK... Western blot analysis of anti-SPHK1 Antibody (Center) (ABIN391346) in ... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of anti-SPHK1 Antibody (N-term) in K562 cell lin... 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Goat Un-conjugated EIA, WB 20 μg Log in to see 6 to 8 Days
$203.50
Details
Cow Goat Un-conjugated EIA, IP, WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Mouse Rabbit Un-conjugated WB 10 blots Log in to see 6 to 8 Days
$588.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of anti-SPHK1 Antibody (N-term P74)(ABIN391347) ... Western blot analysis of SPHK1 (arrow) using rabbit polyclonal SPHK1 A... 400 μL Log in to see 10 to 11 Days
$324.50
Details

SPHK1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human , , , ,
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Mouse (Murine) , , , ,
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Rat (Rattus) , , , ,
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Top referenced anti-Sphingosine Kinase 1 Antibodies

  1. Human Polyclonal SPHK1 Primary Antibody for IHC (p), WB - ABIN391346 : Nayak, Huo, Kwang, Pushparaj, Kumar, Ling, Dheen: Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia. in Neuroscience 2010 (PubMed)
    Show all 17 references for ABIN391346

  2. Human Polyclonal SPHK1 Primary Antibody for EIA, WB - ABIN359437 : Nava, Lacana, Poulton, Liu, Sugiura, Kono, Milstien, Kohama, Spiegel: Functional characterization of human sphingosine kinase-1. in FEBS letters 2000 (PubMed)
    Show all 5 references for ABIN359437

  3. Human Polyclonal SPHK1 Primary Antibody for EIA, IHC (p) - ABIN359438 : Li, Yu, Xia, Zhang, Weng, Zheng, Kong, Hu, Zeng, Zeng, Li, Li, Song: Sphingosine kinase 1 is associated with gastric cancer progression and poor survival of patients. in Clinical cancer research : an official journal of the American Association for Cancer Research 2009 (PubMed)
    Show all 5 references for ABIN359438

  4. Human Polyclonal SPHK1 Primary Antibody for EIA, WB - ABIN359439 : Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: Complete sequencing and characterization of 21,243 full-length human cDNAs. ... in Nature genetics 2003 (PubMed)
    Show all 4 references for ABIN359439

  5. Human Polyclonal SPHK1 Primary Antibody for WB - ABIN391347 : Di, Kawamura, Gao, Tang, Berdyshev, Vogel, Zhao, Sharma, Bachmaier, Xu, Malik: A novel function of sphingosine kinase 1 suppression of JNK activity in preventing inflammation and injury. in The Journal of biological chemistry 2010 (PubMed)
    Show all 2 references for ABIN391347

  6. Human Polyclonal SPHK1 Primary Antibody for WB - ABIN391345 : Hayashi, Nakagami, Takami, Koriyama, Mori, Tamai, Sun, Nagao, Morishita, Kaneda: FHL-2 suppresses VEGF-induced phosphatidylinositol 3-kinase/Akt activation via interaction with sphingosine kinase-1. in Arteriosclerosis, thrombosis, and vascular biology 2009 (PubMed)
    Show all 2 references for ABIN391345

  7. Mouse (Murine) Polyclonal SPHK1 Primary Antibody for WB - ABIN265165 : Kihara, Ikeda, Kariya, Lee, Lee, Igarashi: Sphingosine-1-phosphate lyase is involved in the differentiation of F9 embryonal carcinoma cells to primitive endoderm. in The Journal of biological chemistry 2003 (PubMed)

  8. Human Polyclonal SPHK1 Primary Antibody for EIA, WB - ABIN782886 : Kohama, Olivera, Edsall, Nagiec, Dickson, Spiegel: Molecular cloning and functional characterization of murine sphingosine kinase. in The Journal of biological chemistry 1998 (PubMed)

  9. Human Polyclonal SPHK1 Primary Antibody for ELISA, WB - ABIN308402 : Kase, Hattori, Jojima, Okayasu, Tomizawa, Suzuki, Banba, Monden, Satoh, Akimoto, Kasai: Globular adiponectin induces adhesion molecule expression through the sphingosine kinase pathway in vascular endothelial cells. in Life sciences 2007 (PubMed)

  10. Cow (Bovine) Polyclonal SPHK1 Primary Antibody for EIA, IP - ABIN375022 : Igarashi, Okada, Hayashi, Fujita, Jahangeer, Nakamura: Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis. in The Journal of biological chemistry 2003 (PubMed)

More Antibodies against Sphingosine Kinase 1 Interaction Partners

Fruit Fly (Drosophila melanogaster) Sphingosine Kinase 1 (SPHK1) interaction partners

  1. Sk1 and Sk2 (show KCNN2 Antibodies) are not redundant in biological function and are essential for diverse physiological functions in Drosophila

Arabidopsis thaliana Sphingosine Kinase 1 (SPHK1) interaction partners

  1. SPHK/phyto-S1P (show MBTPS1 Antibodies) and PLDalpha1A are co-dependent in amplification of response to ABA, mediating stomatal closure in Arabidopsis.

  2. Sphingosine kinase 1 phosphorylates sphingosine-1-phosphate and phytosphingosine-1-phosphate, and is coordinately regulated with sphingosine-1-phosphate phosphatase.

Human Sphingosine Kinase 1 (SPHK1) interaction partners

  1. SPHK1 is involved in tumor development and progression of cervical cancer

  2. The silencing of SphK1 potentiated the apoptotic effects of the green tea polyphenol epigallocatechin-3-O-gallate.

  3. increased SK and SPL (show SGPL1 Antibodies) mRNA expression along with reduced sphingosine 1-phosphate levels were more commonly observed in hepatocellular carcinoma tissues.

  4. Hepatitis B virus X protein is able to elevate the expression of SPHK1 in hepatoma cells by upregulating transcription factor AP2 alpha (show TFAP2A Antibodies).

  5. In summary, this study demonstrates a link between SphK1/sphingosine-1-phosphate and TGF-beta (show TGFB1 Antibodies)-induced miR (show MLXIP Antibodies)-21 in renal tubular epithelial cells.

  6. High SPHK1 protein correlated with resistance to cisplatin (IC50) in an independent gastric cancer cell line panel and with survival of patients treated with chemotherapy prior to surgery but not in patients treated with surgery alone.

  7. MiR (show MLXIP Antibodies)-506 suppresses the angiogenesis of liver cancer by inhibiting SPHK1.

  8. Resveratrol-induced proliferation inhibition of K562 cells might be mediated through its modulation activity of SphK1 pathway by regulating S1P (show MBTPS1 Antibodies) and ceramide levels, which then affected the proliferation and apoptosis process of leukemia cells.

  9. Results reveal an lncRNA- and E2F1 (show E2F1 Antibodies)-driven regulatory loop in which E2F1 (show E2F1 Antibodies)-dependent induction of antisense RNA leads to changes in chromatin structure, facilitating E2F1 (show E2F1 Antibodies)-dependent expression of SPHK1 and restriction of E2F1 (show E2F1 Antibodies)-induced apoptosis.

  10. In contrast to the SK activity, S1PP activity was homogeneous across the peripheral blood NK cells, suggesting a bias in the SK pathway towards proliferation and migration, activities supported by S1P (show MBTPS1 Antibodies).

Mouse (Murine) Sphingosine Kinase 1 (SPHK1) interaction partners

  1. Collectively, our results demonstrate that PF-543 exerts potent anti-CRC (show SCRIB Antibodies) activity in vitro and in vivo.

  2. transient receptor potential channel 1 suppression of basal sphingosine kinase 1 activity enables endothelial cell-barrier destabilization by edemagenic agonists

  3. Based on these findings, the authors propose new roles for SK1 in affecting innate responses that regulate susceptibility to dengue virus infection.

  4. Together, these results suggest that alpha-MSH alleviates Dex-induced damages to cultured osteoblasts through activating MC4R (show MC4R Antibodies)-SphK1 signaling.

  5. The study demonstrates a new pathway connecting SphK1 and PPARgamma (show PPARG Antibodies) involved in the pathogenesis of hepatocellular steatosis.

  6. Inhibition of SK1 attenuates the second phase of transmembrane Calcium influx.

  7. The results of this study indicated that Sphk1 plays an essential role in mediating post-stroke neuroinflammation.

  8. Prolonged lowering of plasma S1P, using sphingosine kinase inhibitor, produces pro-atherogenic effects in LDL-R-/- mice that are evident under condition of pronounced hypercholesterolemia.

  9. study provides new insights into the role of SphK1 in hepatocyte survival and uncovers a novel mechanism for protection against ER stress-mediated cell death.

  10. oxLDL induced angiogenesis requires SPHK1/S1P (show S1PR1 Antibodies) signalling both in vitro in a HMEC-1 tube formation model and in vivo in the murine Matrigel plug model

Sphingosine Kinase 1 (SPHK1) Antigen Profile

Protein Summary

The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SPHK1

  • Sphingosine kinase 1 (Sk1) antibody
  • sphingosine kinase 1 (SPHK1) antibody
  • sphingosine kinase 1 (sphk1) antibody
  • sphingosine kinase 1 (LOC100357790) antibody
  • sphingosine kinase 1 (Sphk1) antibody
  • 1110006G24Rik antibody
  • CG1747 antibody
  • Dmel\\CG1747 antibody
  • F18E5.160 antibody
  • F18E5_160 antibody
  • Sk1 antibody
  • sphingosine kinase 1 antibody
  • SPHK antibody
  • SPHK1 antibody
  • Spk1 antibody

Protein level used designations for SPHK1

CG1747-PA , CG1747-PB , Sk1-PA , Sk1-PB , sphingosine kinase 1 , sphingosine kinase I , SK 1 , SPK 1

GENE ID SPECIES
32089 Drosophila melanogaster
427803 Gallus gallus
495437 Xenopus laevis
738821 Pan troglodytes
828239 Arabidopsis thaliana
100058875 Equus caballus
100357790 Oryctolagus cuniculus
8877 Homo sapiens
20698 Mus musculus
618605 Bos taurus
170897 Rattus norvegicus
483329 Canis lupus familiaris
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