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SAS6 is necessary for centrosome duplication and functions during procentriole formation; SAS6 functions to ensure that each centriole seeds the formation of a single procentriole per cell cycle Strnad et al., (2007). Additionally we are shipping Spindle Assembly 6 Homolog (C. Elegans) Proteins (3) and many more products for this protein.
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Human Polyclonal SASS6 Primary Antibody for WB - ABIN531143
Inanç, Pütz, Lalor, Dockery, Kuriyama, Gergely, Morrison: Abnormal centrosomal structure and duplication in Cep135-deficient vertebrate cells. in Molecular biology of the cell 2013
Show all 2 Pubmed References
These results indicate that centriole biogenesis does not strictly depend on SAS-6 self-assembly, and may require preexisting centrioles to ensure structural accuracy, fundamentally deviating from the current paradigm.
Thus, efficient centriole duplication in flies requires the homo-oligomerisation of both Sas-6 and Ana2.
DSas-6 and Ana2 normally cooperate to drive the formation of the centriole inner cartwheel and they promote both centriole duplication and centriole cohesion in a Sak/Plk4 (show PLK4 Antibodies)-dependent manner.
Studies indicate that depletion of any one of the protein kinase (show CDK7 Antibodies) polo-like kinase 4 (PLK4 (show PLK4 Antibodies)) and the two proteins STIL (show STIL Antibodies) and SAS-6 blocks centriole duplication, and, conversely, overexpression causes centriole amplification.
expression of wild-type centriolar assembly protein SAS-6 in a SAS-6-depleted background resulted in centriole sizes that are similar to wild type.
Our present findings revealed that the upregulation of SASS6 expression is involved in the pathogenesis of CRC (show CALR Antibodies) and is associated with a poor prognosis among patients with colon cancer.
SAS6 possesses an intrinsic microtubule assembly promoting activity and its outer exposed C-terminal tail may play critical roles in microtubule assembly and stabilizing microtubule attachment with the centriolar cartwheel.
A homozygous c.185T>C missense mutation in the HsSAS-6 gene is associated with the cause of autosomal recessive primary microcephaly.
HsSAS-6 homodimers are targeted to centrosomes where the local environment and high concentration of HsSAS-6 promote oligomerization, thus initiating procentriole formation.
Authors propose that CEP135 (show CEP135 Antibodies) directly connects the central hub protein, hSAS (show L1CAM Antibodies)-6, to the outer microtubules, and suggest that this interaction stabilizes the proper cartwheel structure for further CPAP (show CENPJ Antibodies)-mediated centriole elongation.
STIL (show STIL Antibodies) cooperates with SAS-6 and PLK4 (show PLK4 Antibodies) in the control of centriole number and represents a key centriole duplication factor in human cells.
hSAS6 depletion hindered STIL (show STIL Antibodies) targeting to the procentriole, implying that STIL (show STIL Antibodies) and hSAS6 are mutually dependent for their centriolar localization.
The activity of SCF (show KITLG Antibodies)-FBXW5 (show FBXW5 Antibodies) is negatively regulated by Polo-like kinase 4 (PLK4 (show PLK4 Antibodies)), which phosphorylates FBXW5 (show FBXW5 Antibodies) at Ser (show SIGLEC1 Antibodies) 151 to suppress its ability to ubiquitylate HsSAS-6.
cea encodes the centriolar coiled-coil protein Sas-6, and that zebrafish Cea/Sas-6 protein localizes to centrosomes.[Cea]
study determined the x-ray structure of the amino-terminal domain of SAS-6 and showed that recombinant SAS-6 self-associates in vitro into assemblies that resemble cartwheel centers
SAS6 is necessary for centrosome duplication and functions during procentriole formation\; SAS6 functions to ensure that each centriole seeds the formation of a single procentriole per cell cycle Strnad et al., (2007)
spindle assembly abnormal protein 6 homolog
, cellular atoll