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SKA3 encodes a component of the spindle and kinetochore-associated protein complex that regulates microtubule attachment to the kinetochores during mitosis. Additionally we are shipping SKA3 Antibodies (50) and many more products for this protein.
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over-expression of GNL3 (show E2IG3 Proteins) and SKA3 in the PC-3 (show PCSK1 Proteins) human prostate cancer cell line decreased in vitro cell migration and invasion
The structure of the Ska core complex is a W-shaped dimer of coiled coils, formed by intertwined interactions between Ska1 (show SKA1 Proteins), Ska2 (show FAM33A Proteins), and Ska3.
Data suggest that Aurora B phosphorylation antagonizes the interaction between the Ska1-3 complex and the KMN network, thereby controlling Ska recruitment to KTs and stabilization of KT-MT attachments.
Ska3 functions to coordinate checkpoint signaling from the microtubule binding sites within a kinetochore by laterally linking the individual binding sites.
C13Orf3 (now termed Ska3) localizes to the spindle and kinetochore throughout mitosis and its depletion markedly delays anaphase transition.
These data identify C13orf3 (Ska3) as an important factor for metaphase to anaphase progression and highlight the potential of combined RNAi screening and protein localisation analyses.
RAMA1 is a novel kinetochore protein involved in kinetochore-microtubule attachment.
The Ska3 subunit was only localized on spindle microtubules from the Pro-MI to MII stages in mouse oocyte meiosis and knockdown by Morpholino injection into mouse oocytes resulted in spindle movement defects and enlarged polar bodies.
This gene encodes a component of the spindle and kinetochore-associated protein complex that regulates microtubule attachment to the kinetochores during mitosis. The encoded protein localizes to the outer kinetechore and may be required for normal chromosome segregation and cell division. Alternative splicing results in multiple transcript variants.
spindle and kinetochore associated complex subunit 3
, spindle and kinetochore-associated protein 3
, Spindle and kinetochore-associated protein RAMA1