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Spinster Homolog 2 (Drosophila) Proteins (SPNS2)

Sphingolipid transporter required for migration of myocardial precursors. Additionally we are shipping SPNS2 Antibodies (31) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SPNS2 216892 Q91VM4
SPNS2 100270678  
SPNS2 124976 Q8IVW8
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Top SPNS2 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Fruit Fly Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details

SPNS2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

Rat (Rattus)
Human

More Proteins for Spinster Homolog 2 (Drosophila) (SPNS2) Interaction Partners

Zebrafish Spinster Homolog 2 (Drosophila) (SPNS2) interaction partners

  1. Toh is required for signaling by S1P (show MBTPS1 Proteins)(2)and is involved in the trafficking or cellular release of S1P (show MBTPS1 Proteins).

  2. findings show that Spns2 in the yolk syncytial layer functions as a sphingosine-1-phosphate (S1P (show MBTPS1 Proteins)) transporter in S1P (show MBTPS1 Proteins) secretion, thereby regulating myocardial precursor migration

Mouse (Murine) Spinster Homolog 2 (Drosophila) (SPNS2) interaction partners

  1. results point to a broad role for Spns2-mediated S1P (show S1PR1 Proteins) transport in the initiation and development of adaptive immune related disorders

  2. Spns2 expression by endothelial cells is essential for secretion of lymph S1P (show S1PR1 Proteins), while Spns2 is dispensable for RBC (show CACNA1C Proteins) secretion of plasma S1P (show S1PR1 Proteins).

  3. Spns2 is an S1P (show S1PR1 Proteins) transporter in vivo that plays a role in regulation not only of blood S1P (show S1PR1 Proteins) but also lymph node and lymph S1P (show S1PR1 Proteins) levels and consequently influences lymphocyte trafficking and lymphatic vessel network organization.

  4. SPNS2 is the first physiological S1P (show S1PR1 Proteins) transporter in mammals and is a key determinant of lymphocyte egress from the thymus.

  5. The changes in lymphocyte subpopulations in mutant Spns2 mice closely mimick the phenotypes of partial sphingosine-1-phosphate (S1P (show S1PR1 Proteins)) deficiency, impaired S1P (show S1PR1 Proteins)-dependent lymphocyte trafficking, and depletion of circulating lymphocytes.

  6. Spns2 functions in endothelial cells to establish the S1P (show S1PR1 Proteins) gradient required for T and B cells to egress from their respective primary lymphoid organs.

  7. The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720.

Human Spinster Homolog 2 (Drosophila) (SPNS2) interaction partners

  1. Spns2 plays key roles in regulating the cellular functions in non-small cell lung cancer (NSCLC) cells

  2. mammals. These findings indicate that Spns2 is required for normal maintenance of the endocochlear potential and hence for normal auditory function, and support a role for S1P (show MBTPS1 Proteins) signalling in hearing.

  3. Spns2 is an S1P (show MBTPS1 Proteins) transporter in vivo that plays a role in regulation not only of blood S1P (show MBTPS1 Proteins) but also lymph node and lymph S1P (show MBTPS1 Proteins) levels and consequently influences lymphocyte trafficking and lymphatic vessel network organization.

  4. The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720.

SPNS2 Protein Profile

Protein Summary

Sphingolipid transporter required for migration of myocardial precursors. Transports sphingosine 1-phosphate (S1P), a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. Mediates the export of S1P from cells in the extraembryonic yolk syncytial layer (YSL), thereby regulating myocardial precursor migration.

Gene names and symbols associated with SPNS2

  • spinster homolog 2 (Drosophila) (SPNS2)
  • spinster homolog 2 (Drosophila) (spns2)
  • spinster homolog 2 (spns2)
  • spinster homolog 2 (Spns2)
  • DKFZp459J1933 protein
  • fi20h04 protein
  • si:dkey-7b17.4 protein
  • toh protein
  • wu:fi20h04 protein

Protein level used designations for SPNS2

spinster homolog 2 (Drosophila) , protein spinster homolog 2 , two of hearts , protein two of hearts , mCG6652-like , spinster-like protein , spinster2

GENE ID SPECIES
417492 Gallus gallus
568117 Danio rerio
606858 Canis lupus familiaris
613889 Bos taurus
100072726 Equus caballus
100145187 Xenopus (Silurana) tropicalis
100172034 Pongo abelii
216892 Mus musculus
100270678 Rattus norvegicus
124976 Homo sapiens
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