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SF3B1 encodes subunit 1 of the splicing factor 3b protein complex. Additionally we are shipping SF3B1 Proteins (3) and SF3B1 Kits (1) and many more products for this protein.
Showing 10 out of 63 products:
Human Polyclonal SF3B1 Primary Antibody for IHC (p), WB - ABIN657676
Corsini, Hothorn, Stier, Rybin, Scheffzek, Gibson, Sattler: Dimerization and protein binding specificity of the U2AF homology motif of the splicing factor Puf60. in The Journal of biological chemistry 2008
Show all 3 references for ABIN657676
Chicken Polyclonal SF3B1 Primary Antibody for IHC, WB - ABIN2778699
Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ... in Proceedings of the National Academy of Sciences of the United States of America 2002
Hamster Monoclonal SF3B1 Primary Antibody for WB - ABIN1449178
Horie, Isono, Koseki: Generation of a monoclonal antibody against the mouse Sf3b1 (SAP155) gene product for U2 snRNP component of spliceosome. in Hybridoma and hybridomics 2003
Chicken Polyclonal SF3B1 Primary Antibody for WB - ABIN2779035
Avila, Bercovich, Westergaard, Levin, Vázquez: Mapping of the protein-binding interface between splicing factors SF3b155 and p14 of Trypanosoma cruzi. in Biochemical and biophysical research communications 2007
Chicken Polyclonal SF3B1 Primary Antibody for IHC, WB - ABIN2778700
Beausoleil, Jedrychowski, Schwartz, Elias, Villén, Li, Cohn, Cantley, Gygi: Large-scale characterization of HeLa cell nuclear phosphoproteins. in Proceedings of the National Academy of Sciences of the United States of America 2004
Data indicate that splicing factor 3b (show SF3B14 Antibodies), subunit 1 (sf3b1) mutation causes aberrant splicing of sf3b1 resulting in functional and predicted non-functional transcripts and a 90% reduction in full-length Sf3b1 protein.
myocardial hypoxia actuates fructose metabolism in human and mouse models of pathological cardiac hypertrophy through hypoxia-inducible factor 1alpha (HIF1alpha (show HIF1A Antibodies)) activation of SF3B1 and SF3B1-mediated splice switching of KHK (show KHK Antibodies)-A to KHK (show KHK Antibodies)-C
Sf3b1 isrequired for the blastocyst formation.
SF3B1 plays an important role in the regulation of hematopoietic stem cells, whereas SF3B1 haploinsufficiency itself is not associated with the myelodysplastic syndrome phenotype with ring sideroblasts.
The level of Sf3b1 expression is critical for the proliferative capacity of hematopoietic stem cells. Depletion of Sf3b1 impairs proliferative capacity of hematopoietic stem cells but is not sufficient to induce myelodysplasia.
SF3B1 haploinsufficiency leads to formation of ring sideroblasts in myelodysplastic syndromes.
the active spliceosome, containing SAP155 phosphorylated by DYRKIA, performs pre-mRNA splicing in spermatogonia during testicular development
active spliceosome, containing phosphorylated SAP155, performs pre-mRNA splicing on chromatin concomitant with transcription during testicular development.
Sf3b1 and Polycomb (show CBX2 Antibodies) group (PcG) proteins interaction is essential for true PcG-mediated repression of Hox (show MSH2 Antibodies) genes.
The finding of this study showed that an SF3B1 (show SF3B2 Antibodies) or EIF1AX (show EIF1AX Antibodies) mutation is present in a substantial subset of primary LMNs underscores that these tumors genetically resemble uveal melanoma and are different from cutaneous melanoma at the genetic level.
SF3B1 (show SF3B2 Antibodies)-mutated myelodysplastic syndrome with ring sideroblasts harbors more severe iron overload and corresponding over-erythropoiesis.
studies reveal new mechanistic insight into SF3B1 (show SF3B2 Antibodies) as a principal player in the spliceosome and as a target of inhibitor compounds
SF3B1 (show SF3B2 Antibodies) - novel candidate genes validated in a large case-control sample of schizophrenia.
In uveal melanoma, the SF3B1 (show SF3B2 Antibodies)(R625/K666) mutation results in deregulated splicing at a subset of junctions, mostly by the use of alternative 3'ss.
Data show that tet methylcytosine dioxygenase 2 TET2 (show TET2 Antibodies), isocitrate dehydrogenases 1/2 IDH1 (show IDH1 Antibodies)/IDH2 (show IDH2 Antibodies), serine/arginine-rich splicing factor 2 SRSF2 (show SRSF2 Antibodies), splicing factor 3b subunit 1 SF3B1, and ras proteins (KRAS/NRAS) are not conserved in dog mast Cell tumors.
SF3B1 (show SF3B2 Antibodies) mutations can propagate from hematopoietic stem cells to myeloid progeny causing myelodysplastic syndromes.
Data suggest SF3B1 (show SF3B2 Antibodies) mutations as a biomarker that can aid in the diagnosis of patients with sideroblastic anemia (SA), allowing for the differentiation between clonal and non-clonal cases of SA.
SF3B1 (show SF3B2 Antibodies) is associated with nucleosomes positioned over exons. SF3B1 (show SF3B2 Antibodies) binding of nucleosomes facilitates the splicing recognition of exons.
Studying transcriptome sequencing data from chronic lymphocytic leukemia, breast cancer and uveal melanoma tumor samples, we show that hundreds of cryptic 3' splice sites (3'SSs) are used in cancers with SF3B1 (show SF3B2 Antibodies) mutations.
This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms.
splicing factor 3b, subunit 1, 155kDa
, splicing factor 3B subunit 1
, splicing factor 3B subunit 1-like
, SAP 155
, pre-mRNA-splicing factor SF3b 155 kDa subunit
, spliceosome-associated protein 155
, splicing factor 3b, subunit 1, 155 kDa
, transforming growth factor alpha regulated gene 4
, splicing factor 3b, subunit 1, 155kD
, 146 kDa nuclear protein
, pre-mRNA processing 10
, pre-mRNA splicing factor SF3b, 155 kDa subunit