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Sprouty-Related, EVH1 Domain Containing 1 Proteins (SPRED1)

The protein encoded by SPRED1 is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. Additionally we are shipping SPRED1 Antibodies (111) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SPRED1 114715 Q924S8
SPRED1 161742 Q7Z699
Rat SPRED1 SPRED1 296072  
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Top SPRED1 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$510.36
Details

SPRED1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human

More Proteins for Sprouty-Related, EVH1 Domain Containing 1 (SPRED1) Interaction Partners

Mouse (Murine) Sprouty-Related, EVH1 Domain Containing 1 (SPRED1) interaction partners

  1. Cosuppression of Sprouty and Sprouty-related negative regulators of FGF signalling in prostate cancer

  2. SPREDs promote self-renewal and inhibit mesodermal differentiation of murine ES cells by selective suppression of the ERK/MAPK (show MAPK1 Proteins) signaling pathway in pluripotent cells

  3. The data suggest that Spred1 negatively regulates group 2 innate lymphoid cell development and functions through the suppression of the Ras-ERK (show EPHB2 Proteins) pathway.

  4. Microrna-126 was transported into recipient human coronary artery endothelial cells by endothelial microparticles and functionally regulated the target protein sprouty-related, EVH1 domain-containing protein 1 (SPRED1).

  5. show that neurofibromin (show NF1 Proteins), the NF1 (show NF1 Proteins) gene product, is a Spred1-interacting protein that is necessary for Spred1's inhibitory function

  6. The results suggest that Spred1 negatively regulates mast cell activation, which is modulated by miR126.

  7. SPRED1 is a likely substrate of SHP2 (show PTPN11 Proteins), whose tyrosine dephosphorylation is required to attenuate the inhibitory action of SPRED1 in the Ras/ERK (show EPHB2 Proteins) pathway.

  8. Data show that both SPRED1 and SPRED2 (show SPRED2 Proteins) inhibit the ability of DYRK1A (show DYRK1A Proteins) to phosphorylate its substrates.

  9. These data suggest that Spreds are key regulators of RhoA (show RHOA Proteins)-mediated cell motility and signal transduction. Furthermore, our study suggests that the induction of Spreds could be a novel strategy for preventing cancer cell metastasis.

  10. Spred-1 and Spred-2 (show SPRED2 Proteins) were found to be expressed predominantly in brain

Human Sprouty-Related, EVH1 Domain Containing 1 (SPRED1) interaction partners

  1. Data suggest SPRED1 EVH1 domain interacts with NF1 (show NF1 Proteins) GRD domain [N-term. 16AA/C-term. 20AA of GTPase-activating protein (show RASA1 Proteins)-related domain]; SPRED1 EVH1 and NF1 (show NF1 Proteins) GRD mutations observed in Legius syndrome reduce binding affinity between EVH1/GRD domains.

  2. Cosuppression of Sprouty and Sprouty-related negative regulators of FGF signalling in prostate cancer

  3. SPRED1 decreased expression correlated with genetic features of AML (show RUNX1 Proteins). Our study reveals a new mechanism which contributes to deregulate RAS MAPK (show MAPK1 Proteins) pathway in the vast majority of paediatric AMLs

  4. Antisense-mediated knockdown (anti-miR (show MLXIP Proteins)) revealed that miR (show MLXIP Proteins)-206/21 coordinately promote RAS-ERK (show EPHB2 Proteins) signaling and the corresponding cell phenotypes by inhibiting translation of the pathway suppressors RASA1 (show RASA1 Proteins) and SPRED1.

  5. SPRED1 seems to play an important role in recruiting neurofibromin (show NF1 Proteins) to the plasma membrane. (Review)

  6. Older age and deletions of IKZF1 (show IKZF1 Proteins) and SPRED1 were also associated with poor overall survival of pediatric B-cell precursor acute lymphoblastic leukemia.

  7. Microrna-126 was transported into recipient human coronary artery endothelial cells by endothelial microparticles and functionally regulated the target protein sprouty-related, EVH1 domain-containing protein 1 (SPRED1).

  8. Based on our current understanding of KIT and SPRED1 protein interactions, we propose that cafe-au-lait macules and freckling may be seen in some patients with piebaldism and does not necessarily represent coexistence of neurofibromatosis type 1 (show NF1 Proteins).

  9. Data indicate that upregulated miR (show MLXIP Proteins)-126 upon coxsackievirus B3 (CVB3) infection targets SPRED1, LRP6 (show LRP6 Proteins), and WRCH1 (show RHOU Proteins) genes, mediating cross-talk between ERK1/2 and Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathways, and thus promoting viral replication.

  10. Sixty-three mutations and deletions are definitely pathogenic or most likely pathogenic, eight SPRED1 mutations are probably benign rare variants, and 17 SPRED1 missense mutations are still unclassified. Review.

SPRED1 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS).

Gene names and symbols associated with SPRED1

  • sprouty-related, EVH1 domain containing 1 (spred1)
  • sprouty-related, EVH1 domain containing 1 (SPRED1)
  • SPRED1 (Bm1_51610)
  • sprouty protein with EVH-1 domain 1, related sequence (Spred1)
  • sprouty-related, EVH1 domain containing 1 (Spred1)
  • 5730461F13Rik protein
  • AL024345 protein
  • AW047647 protein
  • fb14c08 protein
  • fj51c03 protein
  • hSpred1 protein
  • NFLS protein
  • spred-1 protein
  • wu:fb14c08 protein
  • wu:fj51c03 protein
  • Xspred1 protein
  • Xtspred1 protein
  • zgc:85707 protein

Protein level used designations for SPRED1

sprouty-related, EVH1 domain-containing protein 1 , sprouty-related protein with EVH-1 domain 1 , sprouty-related, EVH1 domain containing 1 , spred-1 , sprouty-related, EVH1 domain-containing protein 1-like , SPRED1 , sprouty-related protein 1 with EVH-1 domain , suppressor of Ras/MAPK activation , sprouty protein with EVH-1 domain 1, related sequence

GENE ID SPECIES
406513 Danio rerio
423292 Gallus gallus
467654 Pan troglodytes
487485 Canis lupus familiaris
493399 Xenopus (Silurana) tropicalis
519882 Bos taurus
100057517 Equus caballus
100158360 Xenopus laevis
100512576 Sus scrofa
100563315 Anolis carolinensis
6105207 Brugia malayi
100351685 Oryctolagus cuniculus
100391851 Callithrix jacchus
100482511 Ailuropoda melanoleuca
100544962 Meleagris gallopavo
100583864 Nomascus leucogenys
114715 Mus musculus
161742 Homo sapiens
296072 Rattus norvegicus
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