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Sprouty-Related, EVH1 Domain Containing 2 Proteins (SPRED2)

SPRED2 is a member of the Sprouty (see SPRY1\; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1\; MIM 176948) (Nonami et al., 2004 [PubMed 15465815]).[supplied by OMIM, Mar 2008].. Additionally we are shipping SPRED2 Antibodies (22) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SPRED2 200734 Q7Z698
SPRED2 114716 Q924S7
SPRED2 305539 Q3C2P8
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Top SPRED2 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$3,135.00
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,138.67
Details

SPRED2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Sprouty-Related, EVH1 Domain Containing 2 (SPRED2) Interaction Partners

Human Sprouty-Related, EVH1 Domain Containing 2 (SPRED2) interaction partners

  1. Cosuppression of Sprouty and Sprouty-related negative regulators of FGF signalling in prostate cancer

  2. Spred2 was involved in erythroid differentiation of chronic myeloid leukemia (show BCL11A Proteins) cells and participated in imatinib induced erythroid differentiation partly through ERK (show EPHB2 Proteins) signaling.

  3. Downregulation of SPRED2 mRNA is associated with prostate cancer.

  4. Data present that galectin-1 (show LGALS1 Proteins), ataxin-3 (show ATXN3 Proteins) and sprouty-related EVH1 domain-containing protein 2 (SPRED2) may be associated with the progression and development of Down syndrome.

  5. Tyrosines 303/343/353 within the Sprouty-related domain of Spred2 are essential for its interaction with the p85 subunit of phosphatidylinositol 3-kinase.

  6. the knockdown of Spred2 markedly enhanced tumor growth in vivo.

  7. Sprouty and Spred proteins are negative regulators of the ERK/Elk-1 (show ELK1 Proteins) pathway activation induced not only by growth-factors, but also by reactive lipidic mediators.

  8. data in the present study suggests that Spred2 is a regulator of TGF-beta1 (show TGFB1 Proteins)-induced malignance in transformed keratinocytes

  9. NMR assignment of the human Spred2 EVH1 domain

  10. Spred-2 (show SPRED1 Proteins) was found to be strongly expressed in glandular epithelia and, at the subcellular level, its immunoreactivity was associated with secretory vesicles. It becomes most likely that Spred-2 is involved in the regulation of secretory pathways

Mouse (Murine) Sprouty-Related, EVH1 Domain Containing 2 (SPRED2) interaction partners

  1. Cosuppression of Sprouty and Sprouty-related negative regulators of FGF signalling in prostate cancer

  2. SPREDs promote self-renewal and inhibit mesodermal differentiation of murine ES cells by selective suppression of the ERK/MAPK (show MAPK1 Proteins) signaling pathway in pluripotent cells

  3. Spred-2 controls the development of lipopolysaccharide-induced lung inflammation.

  4. Spred-2 negatively regulates APAP-hepatotoxicity under the control of Kupffer cells and NK cells.

  5. Identification of SPRED2 (sprouty-related protein with EVH1 domain 2) as a negative regulator of the hypothalamic-pituitary-adrenal axis.

  6. Data show that both SPRED1 (show SPRED1 Proteins) and SPRED2 inhibit the ability of DYRK1A (show DYRK1A Proteins) to phosphorylate its substrates.

  7. SPRED2 is likely involved in the regulation of dynamic developmental processes.

  8. Spred-2 functions as a negative regulator of aorta-gonad-mesonephros hematopoiesis by inhibiting hematopoietic cytokine signaling.

  9. These data suggest that Spreds are key regulators of RhoA (show RHOA Proteins)-mediated cell motility and signal transduction. Furthermore, our study suggests that the induction of Spreds could be a novel strategy for preventing cancer cell metastasis.

  10. Spred-1 (show SPRED1 Proteins) and Spred-2 were found to be expressed predominantly in brain. It becomes most likely that Spred-2 is involved in the regulation of secretory pathways

SPRED2 Protein Profile

Protein Summary

SPRED2 is a member of the Sprouty (see SPRY1\; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1\; MIM 176948) (Nonami et al., 2004

Gene names and symbols associated with SPRED2

  • sprouty-related, EVH1 domain containing 2 (SPRED2)
  • sprouty-related, EVH1 domain containing 2 (spred2)
  • sprouty-related, EVH1 domain containing 2b (spred2b)
  • sprouty-related, EVH1 domain containing 2 (Spred2)
  • C79158 protein
  • Spred-2 protein
  • spred2 protein
  • wu:fb93f08 protein
  • Xspred2 protein
  • Xtspred2 protein
  • zgc:77284 protein

Protein level used designations for SPRED2

sprouty-related, EVH1 domain containing 2 , receptor tyrosine kinase inhibitor protein , sprouty-related, EVH1 domain-containing protein 2 , fb93f08 , spred-2 , sprouty-related protein 2 with EVH-1 domain , sprouty-related, EVH1 domain-containing protein 2-like , sprouty-related protein with EVH-1 domain 2 , sprouty protein with EVH-1 domain 2, related sequence

GENE ID SPECIES
421271 Gallus gallus
481397 Canis lupus familiaris
496441 Xenopus (Silurana) tropicalis
519081 Bos taurus
697196 Macaca mulatta
793290 Danio rerio
100062947 Equus caballus
100174296 Pongo abelii
100466726 Ailuropoda melanoleuca
100518067 Sus scrofa
459284 Pan troglodytes
100391761 Callithrix jacchus
100562862 Anolis carolinensis
100588144 Nomascus leucogenys
200734 Homo sapiens
114716 Mus musculus
305539 Rattus norvegicus
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