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Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting enzymes in this pathway. Additionally we are shipping Squalene Epoxidase Kits (6) and Squalene Epoxidase Proteins (4) and many more products for this protein.
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Human Polyclonal SQLE Primary Antibody for EIA, IHC (p) - ABIN954946
Helms, Kemming, Pospisil, Vogt, Buerger, Korsching, Liedtke, Schlotter, Wang, Chan, Brandt: Squalene epoxidase, located on chromosome 8q24.1, is upregulated in 8q+ breast cancer and indicates poor clinical outcome in stage I and II disease. in British journal of cancer 2008
Show all 5 references for ABIN954946
Human Polyclonal SQLE Primary Antibody for WB - ABIN948500
Fromont, Godet, Peyret, Irani, Celhay, Rozet, Cathelineau, Cussenot: 8q24 amplification is associated with Myc expression and prostate cancer progression and is an independent predictor of recurrence after radical prostatectomy. in Human pathology 2013
this study have identified a Squalene Monooxygenase region integrally associated with the endoplasmic reticulum membrane that is likely to interact with cholesterol or respond to cholesterol-induced membrane effects.
overexpression of SQLE in HCC (show FAM126A Antibodies) cells promoted cell proliferation and migration, while downregulation of SQLE inhibited the tumorigenicity of Hepatocellular carcinoma cells in vitro and in vivo.
Data suggest that unsaturated fatty acids (oleate; oleoyl-CoA) stabilize SM/SQLE (which catalyzes 1st oxygenation step in cholesterol synthesis) most likely via inhibition of poly-ubiquitination by MARCH6 (show MARCH6 Antibodies) (membrane-associated ring finger (show PCGF1 Antibodies) [C3HC4] 6).
MARCH6 and squalene monooxygenase (SM) physically interact, and consistent with MARCH6 acting as an E3 ligase, its overexpression reduces SM abundance in a RING-dependent manner.
A cDNA library consisting of 220 upregulated genes in tumour tissue was established and named as LSCC. Differential expression was confirmed in five of these genes, including IGFBP5 (show IGFBP5 Antibodies), SQLE, RAP2B (show RAP2B Antibodies), CLDN1 (show CLDN1 Antibodies), and TBL1XR1 (show TBL1XR1 Antibodies).
Distant metastasis-free survival in stage I/II breast cancer cases was significantly inversely related to SQLE mRNA in multivariate Cox (show COX8A Antibodies) analysis in two independent patient cohorts of 160 patients each
Squalene epoxidase is a strong positional candidate gene for obesity, using squantitative trait locus studies.
results demonstrate critical dependence of a 205 bp region for sterol dependent regulation of squalene epoxidase & uncover a possible framework for SREBP-promoter interaction, including a potent synergy with NF-Y that may be of principal importance.
Requires a redox partner, but cytochrome p450 reductase (show POR Antibodies) is not the only microsomal reductase that will serve this purpose.
Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting enzymes in this pathway.
, squalene monooxygenase