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Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting enzymes in this pathway. Additionally we are shipping Squalene Epoxidase Antibodies (26) and Squalene Epoxidase Kits (7) and many more products for this protein.
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our results pinpoint SQLE as a bona fide metabolic oncogene (show RAB1A Proteins) by amplification, and as a therapeutic target in BC. These findings could have implications in other cancer types.
this study have identified a Squalene Monooxygenase region integrally associated with the endoplasmic reticulum membrane that is likely to interact with cholesterol or respond to cholesterol-induced membrane effects.
overexpression of SQLE in HCC (show FAM126A Proteins) cells promoted cell proliferation and migration, while downregulation of SQLE inhibited the tumorigenicity of Hepatocellular carcinoma cells in vitro and in vivo.
Data suggest that unsaturated fatty acids (oleate; oleoyl-CoA) stabilize SM/SQLE (which catalyzes 1st oxygenation step in cholesterol synthesis) most likely via inhibition of poly-ubiquitination by MARCH6 (show MARCH6 Proteins) (membrane-associated ring finger (show PCGF1 Proteins) [C3HC4] 6).
MARCH6 and squalene monooxygenase (SM) physically interact, and consistent with MARCH6 acting as an E3 ligase, its overexpression reduces SM abundance in a RING-dependent manner.
A cDNA library consisting of 220 upregulated genes in tumour tissue was established and named as LSCC. Differential expression was confirmed in five of these genes, including IGFBP5 (show IGFBP5 Proteins), SQLE, RAP2B (show RAP2B Proteins), CLDN1 (show CLDN1 Proteins), and TBL1XR1 (show TBL1XR1 Proteins).
Distant metastasis-free survival in stage I/II breast cancer cases was significantly inversely related to SQLE mRNA in multivariate Cox (show COX8A Proteins) analysis in two independent patient cohorts of 160 patients each
Squalene epoxidase is a strong positional candidate gene for obesity, using squantitative trait locus studies.
results demonstrate critical dependence of a 205 bp region for sterol dependent regulation of squalene epoxidase & uncover a possible framework for SREBP-promoter interaction, including a potent synergy with NF-Y that may be of principal importance.
Requires a redox partner, but cytochrome p450 reductase (show POR Proteins) is not the only microsomal reductase that will serve this purpose.
Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting enzymes in this pathway.
, squalene monooxygenase